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Protein

Chorismate pyruvate-lyase

Gene

ubiC

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.UniRule annotation

Catalytic activityi

Chorismate = 4-hydroxybenzoate + pyruvate.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36Substrate; via amide nitrogenUniRule annotation1
Binding sitei78SubstrateUniRule annotation1
Binding sitei116Substrate; via amide nitrogenUniRule annotation1
Binding sitei157SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processUbiquinone biosynthesis
LigandPyruvate

Enzyme and pathway databases

UniPathwayiUPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
Chorismate pyruvate-lyaseUniRule annotation (EC:4.1.3.40UniRule annotation)
Short name:
CLUniRule annotation
Short name:
CPLUniRule annotation
Gene namesi
Name:ubiCUniRule annotation
Ordered Locus Names:YPO0310, y0568, YP_0466
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002405861 – 174Chorismate pyruvate-lyaseAdd BLAST174

Proteomic databases

PaxDbiQ8ZJ20

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi187410.y0568

Structurei

3D structure databases

ProteinModelPortaliQ8ZJ20
SMRiQ8ZJ20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105VEI Bacteria
COG3161 LUCA
HOGENOMiHOG000137785
KOiK03181
OMAiELWGRRS

Family and domain databases

Gene3Di3.40.1410.10, 1 hit
HAMAPiMF_01632 UbiC, 1 hit
InterProiView protein in InterPro
IPR007440 Chorismate--pyruvate_lyase
IPR028978 Chorismate_lyase_/UTRA_dom_sf
PANTHERiPTHR38683 PTHR38683, 1 hit
PfamiView protein in Pfam
PF04345 Chor_lyase, 1 hit
SUPFAMiSSF64288 SSF64288, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZJ20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIGDASILK PIQWCATEHP ELPADIADWL MELGSMTRRF EQHCQRVHVE
60 70 80 90 100
PQRECFITRD ALGEEAEHLP VSQRYWLREI VLFGDNVPWL LGRTVIPEET
110 120 130 140 150
LSGPDRALVD LGTLPLGRYL FSGDALTRDY IHVGRQDNLW ARRSLLRLSG
160 170
NPLLLTEVFL PASPLYTHCD SIPK
Length:174
Mass (Da):19,916
Last modified:March 1, 2002 - v1
Checksum:i51A02866228B3ED2
GO

Sequence cautioni

The sequence AAM84156 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAS60736 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL18995.1
AE009952 Genomic DNA Translation: AAM84156.1 Different initiation.
AE017042 Genomic DNA Translation: AAS60736.1 Different initiation.
PIRiAI0038
RefSeqiWP_002209087.1, NZ_PDBR01000009.1
YP_002345391.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM84156; AAM84156; y0568
AAS60736; AAS60736; YP_0466
GeneIDi1173155
KEGGiype:YPO0310
ypk:y0568
ypm:YP_0466
PATRICifig|214092.21.peg.545

Similar proteinsi

Entry informationi

Entry nameiUBIC_YERPE
AccessioniPrimary (citable) accession number: Q8ZJ20
Secondary accession number(s): Q0WJZ7, Q74XF8, Q8D1F4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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