Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycerol-3-phosphate acyltransferase

Gene

plsB

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.UniRule annotation

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase (plsB), Glycerol-3-phosphate acyltransferase (plsB)
  2. no protein annotated in this organism
  3. Phosphatidate cytidylyltransferase (cdsA2), Phosphatidate cytidylyltransferase (cdsA1), Phosphatidate cytidylyltransferase (ynbB), Phosphatidate cytidylyltransferase (cds)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate acyltransferaseUniRule annotation (EC:2.3.1.15UniRule annotation)
Short name:
GPATUniRule annotation
Gene namesi
Name:plsBUniRule annotation
Ordered Locus Names:YPO0312, y0570, YP_0468
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001952431 – 825Glycerol-3-phosphate acyltransferaseAdd BLAST825

Proteomic databases

PaxDbiQ8ZJ18

Interactioni

Protein-protein interaction databases

IntActiQ8ZJ18, 2 interactors
STRINGi187410.y0570

Structurei

3D structure databases

ProteinModelPortaliQ8ZJ18
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi305 – 310HXXXXD motif6

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.UniRule annotation

Sequence similaritiesi

Belongs to the GPAT/DAPAT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E55 Bacteria
COG2937 LUCA
HOGENOMiHOG000218231
KOiK00631
OMAiEVIYVPC

Family and domain databases

HAMAPiMF_00393 Glyc3P_acyltrans, 1 hit
InterProiView protein in InterPro
IPR022284 GPAT/DHAPAT
IPR028354 GPAT_PlsB
IPR002123 Plipid/glycerol_acylTrfase
PANTHERiPTHR12563 PTHR12563, 1 hit
PfamiView protein in Pfam
PF01553 Acyltransferase, 1 hit
PIRSFiPIRSF500064 GPAT, 1 hit
PIRSF000437 GPAT_DHAPAT, 1 hit
SMARTiView protein in SMART
SM00563 PlsC, 1 hit
TIGRFAMsiTIGR03703 plsB, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZJ18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGWRKIYYK LLNLPLKLLV KSKVIPADPV SELGLDPSRP ILYVLPYNSK
60 70 80 90 100
ADLLTLRAQC LAQDLPDPLI PLEIDGVQLP SHVFIENGPR VFRYYVPKQE
110 120 130 140 150
SVKLFHDYLD LHRNNPALDI QMLPVSVMFG RSPGREGHGT PHLRVLNGVQ
160 170 180 190 200
KFFAVLWLGR DSFVRFSTTV SLRRMASEHG TDKTIAHKLA RVARMHFSRQ
210 220 230 240 250
RLAAVGPSLP ARQDLFKKLL ASKAIEKAVA DEARSKKISH EKAQQNAITL
260 270 280 290 300
MEEIAANFSY EAVRLSDRVL SWTWNRLYQG INVHNAERVR QLAQDGHEIV
310 320 330 340 350
YVPCHRSHMD YLLLSYVLYH QGLVPPHIAA GINLNFWPAG PIFRRLGAFF
360 370 380 390 400
IRRTFKGNKL YSTVFREYLG ELFTRGYSVE YFVEGGRSRT GRLLEPKTGT
410 420 430 440 450
LSMTIQAMLR GGTRPITLVP IYIGYEHVME VGTYAKELRG AIKEKENLLQ
460 470 480 490 500
MLRGLRKLRN LGQGYVNFGE PLPLTTYLNT HVPQWRDAID PIEAQRPSWL
510 520 530 540 550
TPAVNDLANQ IMVRINNAAA ANAMNLCSTA LLASRQRSLT REQLLEQLDC
560 570 580 590 600
YLQLMRNAPY AKDTTVPDKT PEELLNHALN MNKFEVEKDT IGDIIILPRE
610 620 630 640 650
QAVLMTYYRN NIQHLLILPS LIASMVMYHR RITRTELLHK ISMIYPMLKA
660 670 680 690 700
ELFLHYSKEQ LPETLDTLID ELARQQLICD KGSELVLNPA RIRPLQLLAA
710 720 730 740 750
GVRETLQRYA ITLSLLSATP SINRGALEKE SRIMAQRLSV LHGINAPEFF
760 770 780 790 800
DKAVFSTLVA TLREEGYISD SGDAIQEHTL EVYNMLSALM TPEVKLTIES
810 820
VSMPAETSNQ PEAPETPEPE GKTES
Length:825
Mass (Da):93,621
Last modified:March 1, 2002 - v1
Checksum:i0D0C9A0CDC751127
GO

Sequence cautioni

The sequence AAM84158 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAS60738 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL18997.1
AE009952 Genomic DNA Translation: AAM84158.1 Different initiation.
AE017042 Genomic DNA Translation: AAS60738.1 Different initiation.
PIRiAC0039
RefSeqiWP_002214644.1, NZ_PDBR01000009.1
YP_002345393.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM84158; AAM84158; y0570
AAS60738; AAS60738; YP_0468
GeneIDi1173157
KEGGiype:YPO0312
ypk:y0570
ypm:YP_0468
PATRICifig|214092.21.peg.547

Similar proteinsi

Entry informationi

Entry nameiPLSB_YERPE
AccessioniPrimary (citable) accession number: Q8ZJ18
Secondary accession number(s): Q0WJZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health