Reviewed, UniProtKB/Swiss-Prot Q8ZJ10 (ALR1_YERPE)

Names and origin

Protein names

Recommended name:
    Alanine racemase 1
    EC=5.1.1.1

Gene names

Name:	alr1
Synonyms:	alr
Ordered Locus Names:	YPO0321, y0578, YP_0476

Organism

Yersinia pestis [Complete proteome] [HAMAP]

Taxonomic identifier

632 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Provides the D-alanine required for cell wall biosynthesis By similarity.
Catalytic activity	L-alanine = D-alanine. HAMAP MF_01201
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP MF_01201 Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_01201
Sequence similarities	Belongs to the alanine racemase family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	alanine metabolic process Inferred from electronic annotation. Source: HAMAP cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alanine racemase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Alanine racemase 1 HAMAP MF_01201		PRO_0000114602
Sites
	Active site	34	1	Proton acceptor; specific for D-alanine By similarity
	Active site	254	1	Proton acceptor; specific for L-alanine By similarity
Amino acid modifications
	Modified residue	34	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8ZJ10-1 [UniParc]. Last modified March 5, 2002. Version 1. Checksum: 5A12985B1FE6964F	FASTA	359	38,731
	10 20 30 40 50 60 MKAATAVIDR HALRHNLQQI RRLAPQSRLV AVVKANAYGH GLLAAAHTLQ DADCYGVARI 70 80 90 100 110 120 SEALMLRAGG IVKPILLLEG FFDAEDLPVL VANHIETAVH SLEQLVALEA ATLSAPINVW 130 140 150 160 170 180 MKLDTGMHRL GVRPDQAEAF YQRLSACRNV IQPVNIMSHF SRADEPEVAA TQQQLACFDA 190 200 210 220 230 240 FAAGKPGKQS IAASGGILRW PQAHRDWVRP GIVLYGVSPF DAPYGRDFGL LPAMTLKSSL 250 260 270 280 290 300 IAVREHKAGE SVGYGGTWVS ERDTRLGVIA IGYGDGYPRS APSGTPVWLN GREVSIVGRV 310 320 330 340 350 SMDMISIDLG PESTDKVGDE ALMWGAELPV ERVAACTGIS AYELITNLTS RVAMEYLGE

References

[1]	"Genome sequence of Yersinia pestis, the causative agent of plague." Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:523-527(2001) [PubMed: 11586360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CO-92 / Biovar Orientalis.
[2]	"Genome sequence of Yersinia pestis KIM." Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. , Matson J.S., Blattner F.R., Perry R.D. J. Bacteriol. 184:4601-4611(2002) [PubMed: 12142430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KIM5 / Biovar Mediaevalis.
[3]	"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans." Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R. DNA Res. 11:179-197(2004) [PubMed: 15368893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL590842 Genomic DNA. Translation: CAL19005.1. AE009952 Genomic DNA. Translation: AAM84166.1. AE017042 Genomic DNA. Translation: AAS60746.1.
PIR	AC0040.
RefSeq	NP_667915.1. NP_991869.1. YP_002345401.1.
3D structure databases
HSSP	HSSP built from PDB template 1BD0 based on UniProtKB P10724.
ModBase	Search...
Genome annotation databases
GeneID	1145525. 1173165. 2766961.
GenomeReviews	Gene locus y0578 in contig AE009952_GR. Gene locus YP_0476 in contig AE017042_GR. Gene locus YPO0321 in contig AL590842_GR.
KEGG	ype:YPO0321. ypk:y0578. ypm:YP_0476.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8ZJ10.
OMA	PTHERSI.
Enzyme and pathway databases
BioCyc	YPES187410:Y0578-MON. YPES229193:YP0476-MON.
BRENDA	5.1.1.1. 142588.
Family and domain databases
HAMAP	MF_01201. [Tree]
InterPro	IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR000821. Ala_racemase_reg. [Graphical view]
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
TIGRFAMs	TIGR00492. alr. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALR1_YERPE

Accession

Primary (citable) accession number: Q8ZJ10
Secondary accession number(s): Q0WJY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	March 5, 2002
Last modified:	November 3, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)