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Protein

HTH-type transcriptional activator RhaR

Gene

rhaR

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Activates expression of the rhaSR operon in response to L-rhamnose.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi195 – 21420H-T-H motifUniRule annotationAdd
BLAST
DNA bindingi244 – 26724H-T-H motifUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Rhamnose metabolism, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYPES214092:GKDD-330-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional activator RhaRUniRule annotation
Alternative name(s):
L-rhamnose operon transcriptional activator RhaRUniRule annotation
Gene namesi
Name:rhaRUniRule annotation
Ordered Locus Names:YPO0333, y0591, YP_0488
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290HTH-type transcriptional activator RhaRPRO_0000194561Add
BLAST

Interactioni

Subunit structurei

Binds DNA as a dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei246 – 2461Interaction with sigma-70UniRule annotation

Protein-protein interaction databases

STRINGi187410.y0591.

Structurei

3D structure databases

ProteinModelPortaliQ8ZIZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 HTH araC/xylS-type DNA-binding domains.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108BRW. Bacteria.
ENOG410XYX0. LUCA.
HOGENOMiHOG000290513.
KOiK02854.
OMAiDWAAHIP.
OrthoDBiEOG6Z3KH4.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
2.60.120.280. 1 hit.
HAMAPiMF_01533. HTH_type_RhaR.
InterProiIPR003313. AraC-bd.
IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR011051. RmlC_Cupin.
IPR023699. Tscrpt_act_RhaR.
IPR020449. Tscrpt_reg_HTH_AraC-type.
[Graphical view]
PfamiPF02311. AraC_binding. 1 hit.
PF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF51182. SSF51182. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZIZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAPLLLESR DYLLSEQMPV AVTNRYPQET FVEHTHQFCE IVIVWRGNGL
60 70 80 90 100
HVLNDHPYRI TCGDVFYIQA ADHHSYESVH DLVLDNIIYC PERLHLNAQW
110 120 130 140 150
HKLLPPLGPE QNQGYWRLTT QGMAQARPII QQLAQESRKT DSWSIQLTEV
160 170 180 190 200
LLLQLAIVLK RHRYRAEQAH LLPDGEQLDL IMSALQQSLG AYFDMADFCH
210 220 230 240 250
KNQLVERSLK QLFRQQTGMS ISHYLRQIRL CHAKCLLRGS EHRISDIAAR
260 270 280 290
CGFEDSNYFS AVFTREAGMT PRDYRQRFIR SPVLPAKNEP
Length:290
Mass (Da):33,775
Last modified:March 1, 2002 - v1
Checksum:i28446572FBE3F975
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL19017.1.
AE009952 Genomic DNA. Translation: AAM84179.1.
AE017042 Genomic DNA. Translation: AAS60758.1.
PIRiAG0041.
RefSeqiWP_002209110.1. NZ_LIXY01000001.1.
YP_002345413.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM84179; AAM84179; y0591.
AAS60758; AAS60758; YP_0488.
GeneIDi1173177.
KEGGiype:YPO0333.
ypj:CH55_3430.
ypk:y0591.
ypl:CH46_581.
ypm:YP_0488.
ypv:BZ15_3239.
ypw:CH59_1531.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL19017.1.
AE009952 Genomic DNA. Translation: AAM84179.1.
AE017042 Genomic DNA. Translation: AAS60758.1.
PIRiAG0041.
RefSeqiWP_002209110.1. NZ_LIXY01000001.1.
YP_002345413.1. NC_003143.1.

3D structure databases

ProteinModelPortaliQ8ZIZ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187410.y0591.

Protocols and materials databases

DNASUi1145538.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM84179; AAM84179; y0591.
AAS60758; AAS60758; YP_0488.
GeneIDi1173177.
KEGGiype:YPO0333.
ypj:CH55_3430.
ypk:y0591.
ypl:CH46_581.
ypm:YP_0488.
ypv:BZ15_3239.
ypw:CH59_1531.

Phylogenomic databases

eggNOGiENOG4108BRW. Bacteria.
ENOG410XYX0. LUCA.
HOGENOMiHOG000290513.
KOiK02854.
OMAiDWAAHIP.
OrthoDBiEOG6Z3KH4.

Enzyme and pathway databases

BioCyciYPES214092:GKDD-330-MONOMER.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
2.60.120.280. 1 hit.
HAMAPiMF_01533. HTH_type_RhaR.
InterProiIPR003313. AraC-bd.
IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR011051. RmlC_Cupin.
IPR023699. Tscrpt_act_RhaR.
IPR020449. Tscrpt_reg_HTH_AraC-type.
[Graphical view]
PfamiPF02311. AraC_binding. 1 hit.
PF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF51182. SSF51182. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiRHAR_YERPE
AccessioniPrimary (citable) accession number: Q8ZIZ9
Secondary accession number(s): Q0WJX5, Q74XE4, Q7CKN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.