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Q8ZIK7

- APAH_YERPE

UniProt

Q8ZIK7 - APAH_YERPE

Protein

Bis(5'-nucleosyl)-tetraphosphatase, symmetrical

Gene

apaH

Organism
Yersinia pestis
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (27 Mar 2002)
      Previous versions | rss
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    Functioni

    Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.UniRule annotation

    Catalytic activityi

    P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP.UniRule annotation

    GO - Molecular functioni

    1. bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciYPES214092:GKDD-486-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bis(5'-nucleosyl)-tetraphosphatase, symmetricalUniRule annotation (EC:3.6.1.41UniRule annotation)
    Alternative name(s):
    Ap4A hydrolaseUniRule annotation
    Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolaseUniRule annotation
    Diadenosine tetraphosphataseUniRule annotation
    Gene namesi
    Name:apaHUniRule annotation
    Ordered Locus Names:YPO0490, y3685, YP_3689
    OrganismiYersinia pestis
    Taxonomic identifieri632 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Bis(5'-nucleosyl)-tetraphosphatase, symmetricalPRO_0000198021Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi214092.YPO0490.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8ZIK7.
    SMRiQ8ZIK7. Positions 2-266.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Ap4A hydrolase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0639.
    HOGENOMiHOG000251871.
    KOiK01525.
    OMAiINAFTRM.
    OrthoDBiEOG66B3WP.

    Family and domain databases

    Gene3Di3.60.21.10. 2 hits.
    HAMAPiMF_00199. ApaH.
    InterProiIPR004617. ApaH.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
    SUPFAMiSSF56300. SSF56300. 1 hit.
    TIGRFAMsiTIGR00668. apaH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8ZIK7-1 [UniParc]FASTAAdd to Basket

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    MSTYLIGDIH GCLDELLALL AQVNFDPQQD TLWLTGDLVA RGPASLDVLR    50
    YVRSLGPAVR MVLGNHDLHL LAVYAGISRN KPKDRITPLL DAPDADELIN 100
    WLRRQPVLQV DDQLKLIMAH AGITPQWDIE TAKMCAREVE AVLSSDSYPL 150
    FLDAMYGDMP NNWSPELTGL ARLRFSTNAL TRMRFCFPNG QLDMICKDTP 200
    ENAPAPLKPW FDLPRLVDPE YSIIFGHWAS LEGKGVPEGI YGLDTGCCWG 250
    GDLTLLRWDD KRYFTQRAFK AEAEINNNNG FAAGEAVQH 289
    Length:289
    Mass (Da):32,341
    Last modified:March 27, 2002 - v1
    Checksum:i6E761EBC8A6A4A4A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL19170.1.
    AE009952 Genomic DNA. Translation: AAM87233.1.
    AE017042 Genomic DNA. Translation: AAS63837.1.
    PIRiAH0060.
    RefSeqiNP_670982.1. NC_004088.1.
    NP_994960.1. NC_005810.1.
    YP_002345563.1. NC_003143.1.

    Genome annotation databases

    EnsemblBacteriaiAAM87233; AAM87233; y3685.
    AAS63837; AAS63837; YP_3689.
    GeneIDi1148632.
    1173335.
    2764263.
    KEGGiype:YPO0490.
    ypk:y3685.
    ypm:YP_3689.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL19170.1 .
    AE009952 Genomic DNA. Translation: AAM87233.1 .
    AE017042 Genomic DNA. Translation: AAS63837.1 .
    PIRi AH0060.
    RefSeqi NP_670982.1. NC_004088.1.
    NP_994960.1. NC_005810.1.
    YP_002345563.1. NC_003143.1.

    3D structure databases

    ProteinModelPortali Q8ZIK7.
    SMRi Q8ZIK7. Positions 2-266.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 214092.YPO0490.

    Protocols and materials databases

    DNASUi 1148632.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM87233 ; AAM87233 ; y3685 .
    AAS63837 ; AAS63837 ; YP_3689 .
    GeneIDi 1148632.
    1173335.
    2764263.
    KEGGi ype:YPO0490.
    ypk:y3685.
    ypm:YP_3689.

    Phylogenomic databases

    eggNOGi COG0639.
    HOGENOMi HOG000251871.
    KOi K01525.
    OMAi INAFTRM.
    OrthoDBi EOG66B3WP.

    Enzyme and pathway databases

    BioCyci YPES214092:GKDD-486-MONOMER.

    Family and domain databases

    Gene3Di 3.60.21.10. 2 hits.
    HAMAPi MF_00199. ApaH.
    InterProi IPR004617. ApaH.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000903. B5n-ttraPtase_sm. 1 hit.
    SUPFAMi SSF56300. SSF56300. 1 hit.
    TIGRFAMsi TIGR00668. apaH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CO-92 / Biovar Orientalis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIM10+ / Biovar Mediaevalis.
    3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
      Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
      , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
      DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 91001 / Biovar Mediaevalis.

    Entry informationi

    Entry nameiAPAH_YERPE
    AccessioniPrimary (citable) accession number: Q8ZIK7
    Secondary accession number(s): Q0WJH5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: March 27, 2002
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3