Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8ZIK7 (APAH_YERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical

EC=3.6.1.41
Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase
Gene names
Name:apaH
Ordered Locus Names:YPO0490, y3685, YP_3689
OrganismYersinia pestis [Reference proteome] [HAMAP]
Taxonomic identifier632 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity. HAMAP-Rule MF_00199

Catalytic activity

P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP-Rule MF_00199

Sequence similarities

Belongs to the Ap4A hydrolase family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionbis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP-Rule MF_00199
PRO_0000198021

Sequences

Sequence LengthMass (Da)Tools
Q8ZIK7 [UniParc].

Last modified March 27, 2002. Version 1.
Checksum: 6E761EBC8A6A4A4A

FASTA28932,341
        10         20         30         40         50         60 
MSTYLIGDIH GCLDELLALL AQVNFDPQQD TLWLTGDLVA RGPASLDVLR YVRSLGPAVR 

        70         80         90        100        110        120 
MVLGNHDLHL LAVYAGISRN KPKDRITPLL DAPDADELIN WLRRQPVLQV DDQLKLIMAH 

       130        140        150        160        170        180 
AGITPQWDIE TAKMCAREVE AVLSSDSYPL FLDAMYGDMP NNWSPELTGL ARLRFSTNAL 

       190        200        210        220        230        240 
TRMRFCFPNG QLDMICKDTP ENAPAPLKPW FDLPRLVDPE YSIIFGHWAS LEGKGVPEGI 

       250        260        270        280 
YGLDTGCCWG GDLTLLRWDD KRYFTQRAFK AEAEINNNNG FAAGEAVQH 

« Hide

References

[1]"Genome sequence of Yersinia pestis, the causative agent of plague."
Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. expand/collapse author list , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.
Nature 413:523-527(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CO-92 / Biovar Orientalis.
[2]"Genome sequence of Yersinia pestis KIM."
Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. expand/collapse author list , Matson J.S., Blattner F.R., Perry R.D.
J. Bacteriol. 184:4601-4611(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KIM10+ / Biovar Mediaevalis.
[3]"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. expand/collapse author list , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL590842 Genomic DNA. Translation: CAL19170.1.
AE009952 Genomic DNA. Translation: AAM87233.1.
AE017042 Genomic DNA. Translation: AAS63837.1.
PIRAH0060.
RefSeqNP_670982.1. NC_004088.1.
NP_994960.1. NC_005810.1.
YP_002345563.1. NC_003143.1.

3D structure databases

ProteinModelPortalQ8ZIK7.
SMRQ8ZIK7. Positions 2-266.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING214092.YPO0490.

Protocols and materials databases

DNASU1148632.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM87233; AAM87233; y3685.
AAS63837; AAS63837; YP_3689.
GeneID1148632.
1173335.
2764263.
KEGGype:YPO0490.
ypk:y3685.
ypm:YP_3689.

Phylogenomic databases

eggNOGCOG0639.
HOGENOMHOG000251871.
KOK01525.
OMAINAFTRM.
OrthoDBEOG66B3WP.

Enzyme and pathway databases

BioCycYPES214092:GKDD-486-MONOMER.

Family and domain databases

Gene3D3.60.21.10. 2 hits.
HAMAPMF_00199. ApaH.
InterProIPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFPIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMSSF56300. SSF56300. 1 hit.
TIGRFAMsTIGR00668. apaH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAPAH_YERPE
AccessionPrimary (citable) accession number: Q8ZIK7
Secondary accession number(s): Q0WJH5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: June 11, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families