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Protein

Bis(5'-nucleosyl)-tetraphosphatase, symmetrical

Gene

apaH

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.UniRule annotation

Catalytic activityi

P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP.UniRule annotation

GO - Molecular functioni

  1. bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciYPES214092:GKDD-486-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetricalUniRule annotation (EC:3.6.1.41UniRule annotation)
Alternative name(s):
Ap4A hydrolaseUniRule annotation
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolaseUniRule annotation
Diadenosine tetraphosphataseUniRule annotation
Gene namesi
Name:apaHUniRule annotation
Ordered Locus Names:YPO0490, y3685, YP_3689
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815 Componenti: Chromosome UP000001019 Componenti: Chromosome UP000002490 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Bis(5'-nucleosyl)-tetraphosphatase, symmetricalPRO_0000198021Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi214092.YPO0490.

Structurei

3D structure databases

ProteinModelPortaliQ8ZIK7.
SMRiQ8ZIK7. Positions 2-266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Ap4A hydrolase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000251871.
KOiK01525.
OMAiMPWFDVP.
OrthoDBiEOG66B3WP.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
HAMAPiMF_00199. ApaH.
InterProiIPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR00668. apaH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZIK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTYLIGDIH GCLDELLALL AQVNFDPQQD TLWLTGDLVA RGPASLDVLR
60 70 80 90 100
YVRSLGPAVR MVLGNHDLHL LAVYAGISRN KPKDRITPLL DAPDADELIN
110 120 130 140 150
WLRRQPVLQV DDQLKLIMAH AGITPQWDIE TAKMCAREVE AVLSSDSYPL
160 170 180 190 200
FLDAMYGDMP NNWSPELTGL ARLRFSTNAL TRMRFCFPNG QLDMICKDTP
210 220 230 240 250
ENAPAPLKPW FDLPRLVDPE YSIIFGHWAS LEGKGVPEGI YGLDTGCCWG
260 270 280
GDLTLLRWDD KRYFTQRAFK AEAEINNNNG FAAGEAVQH
Length:289
Mass (Da):32,341
Last modified:March 27, 2002 - v1
Checksum:i6E761EBC8A6A4A4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL19170.1.
AE009952 Genomic DNA. Translation: AAM87233.1.
AE017042 Genomic DNA. Translation: AAS63837.1.
PIRiAH0060.
RefSeqiNP_670982.1. NC_004088.1.
NP_994960.1. NC_005810.1.
WP_002210492.1. NZ_KN150724.1.
YP_002345563.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM87233; AAM87233; y3685.
AAS63837; AAS63837; YP_3689.
GeneIDi1173335.
KEGGiype:YPO0490.
ypk:y3685.
ypm:YP_3689.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL19170.1.
AE009952 Genomic DNA. Translation: AAM87233.1.
AE017042 Genomic DNA. Translation: AAS63837.1.
PIRiAH0060.
RefSeqiNP_670982.1. NC_004088.1.
NP_994960.1. NC_005810.1.
WP_002210492.1. NZ_KN150724.1.
YP_002345563.1. NC_003143.1.

3D structure databases

ProteinModelPortaliQ8ZIK7.
SMRiQ8ZIK7. Positions 2-266.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi214092.YPO0490.

Protocols and materials databases

DNASUi1148632.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM87233; AAM87233; y3685.
AAS63837; AAS63837; YP_3689.
GeneIDi1173335.
KEGGiype:YPO0490.
ypk:y3685.
ypm:YP_3689.

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000251871.
KOiK01525.
OMAiMPWFDVP.
OrthoDBiEOG66B3WP.

Enzyme and pathway databases

BioCyciYPES214092:GKDD-486-MONOMER.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
HAMAPiMF_00199. ApaH.
InterProiIPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR00668. apaH. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiAPAH_YERPE
AccessioniPrimary (citable) accession number: Q8ZIK7
Secondary accession number(s): Q0WJH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: April 1, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.