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Reviewed, UniProtKB/Swiss-Prot Q8ZIC5 (UXAB_YERPE)

Last modified November 25, 2008. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Altronate oxidoreductase
    EC=1.1.1.58
Alternative name(s):
    Tagaturonate reductase
    Tagaturonate dehydrogenase
Gene names
Name: uxaB
Ordered Locus Names: YPO0580, y3599, YP_2900
OrganismYersinia pestis [Complete proteome] [HAMAP]
Taxonomic identifier632 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

D-altronate + NAD(+) = D-tagaturonate + NADH.

Pathway

Carbohydrate metabolism; pentose and glucuronate interconversion.

Sequence similarities

Belongs to the mannitol dehydrogenase family. UxaB subfamily.

Ontologies

Keywords

   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

tagaturonate reductase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 483483Altronate oxidoreductase
PRO_0000170746

Regions

Nucleotide binding18 – 2912NAD By similarity

Experimental info

Sequence conflict4551A → S in AAS63082. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8ZIC5-1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: BDDB13837F6564B4

FASTA48354,907
        10         20         30         40         50         60 
MQTLNRRDFP GRSHPDKIIQ FGEGNFLRAF VDWQIDLLNE HTDLNAGIVV IRPIDTDFPP 

        70         80         90        100        110        120 
SLSTQDGLYT AVIRGLNEQG EAVRESRLIR SVNREINIYR QFDDYLALAR DANIRFMFSN 

       130        140        150        160        170        180 
TTEAGIAWNE ADQFSDAPPS SFPAKLTRLL FERFEHFDGA ADKGWVLLPC ELIDYNGEAL 

       190        200        210        220        230        240 
RELVLRYASH WQLPAAFTHW LTENNTFCST LVDRIVTGYP RDEVAALQTE LGYQDSFLDT 

       250        260        270        280        290        300 
AEYFYLFVIQ GPQGLAQELR LDQLDLNVRI VDDIKPYKER KVAILNGAHT ALVPVAYLSG 

       310        320        330        340        350        360 
LDTVGQTMDD AQISRFVEKT ITEEIVPVLD LPEDELLSFS QAVLSRFRNP FIQHQLLSIA 

       370        380        390        400        410        420 
LNGMTKFRTR ILPQLLTYQQ QKGQLPPRLT FALAALIAFY RGEREGQTYP LQDDAHWLER 

       430        440        450        460        470        480 
YSTLWNGVKH GDIALAELVN RVLSDANHWG QDLTAVPQLA NQVTEQLQTI LSRGMRAAVA 


AYS 

« Hide

References

[1]"Genome sequence of Yersinia pestis, the causative agent of plague."
Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. expand/collapse author list , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.
Nature 413:523-527(2001) [PubMed: 11586360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CO-92 / Biovar Orientalis.
[2]"Genome sequence of Yersinia pestis KIM."
Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. expand/collapse author list , Matson J.S., Blattner F.R., Perry R.D.
J. Bacteriol. 184:4601-4611(2002) [PubMed: 12142430] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KIM5 / Biovar Mediaevalis.
[3]"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. expand/collapse author list , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
DNA Res. 11:179-197(2004) [PubMed: 15368893] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases

AL590842 Genomic DNA. Translation: CAL19260.1.
AE009952 Genomic DNA. Translation: AAM87147.1.
AE017042 Genomic DNA. Translation: AAS63082.1.
PIRAB0072.
RefSeqNP_670896.1.
NP_994205.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1148546.
2763598.
GenomeReviewsGene locus y3599 in contig AE009952_GR.
Gene locus YP_2900 in contig AE017042_GR.
Gene locus YPO0580 in contig AL590842_GR.
KEGGype:YPO0580.
ypk:y3599.
ypm:YP_2900.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ8ZIC5.

Enzyme and pathway databases

BioCycYPES187410:Y3599-MON.
YPES214092:YPO0580-MON.
YPES229193:YP2900-MON.

Family and domain databases

HAMAPMF_00670.
[Tree]
InterProIPR013328. DHase_multihelical.
IPR013118. Mannitol_DHase_C.
IPR013131. Mannitol_DHase_N.
IPR016040. NAD(P)-bd.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUXAB_YERPE
AccessionPrimary (citable) accession number: Q8ZIC5
Secondary accession number(s): Q0WJ86
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: March 1, 2002
Last modified: November 25, 2008
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents