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Protein

Altronate oxidoreductase

Gene

uxaB

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-altronate + NAD+ = D-tagaturonate + NADH.UniRule annotation

Pathwayi: pentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 29NADUniRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00246

Names & Taxonomyi

Protein namesi
Recommended name:
Altronate oxidoreductaseUniRule annotation (EC:1.1.1.58UniRule annotation)
Alternative name(s):
Tagaturonate dehydrogenaseUniRule annotation
Tagaturonate reductaseUniRule annotation
Gene namesi
Name:uxaBUniRule annotation
Ordered Locus Names:YPO0580, y3599, YP_2900
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001707461 – 483Altronate oxidoreductaseAdd BLAST483

Proteomic databases

PaxDbiQ8ZIC5

Interactioni

Protein-protein interaction databases

IntActiQ8ZIC5, 2 interactors
STRINGi187410.y3599

Structurei

3D structure databases

ProteinModelPortaliQ8ZIC5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mannitol dehydrogenase family. UxaB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QZW Bacteria
COG0246 LUCA
HOGENOMiHOG000029586
KOiK00041
OMAiVVIVRPI

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
HAMAPiMF_00670 Altron_oxidoreduct, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR023668 Altronate_OxRdtase
IPR013118 Mannitol_DH_C
IPR013131 Mannitol_DH_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF01232 Mannitol_dh, 1 hit
PF08125 Mannitol_dh_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZIC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTLNRRDFP GRSHPDKIIQ FGEGNFLRAF VDWQIDLLNE HTDLNAGIVV
60 70 80 90 100
IRPIDTDFPP SLSTQDGLYT AVIRGLNEQG EAVRESRLIR SVNREINIYR
110 120 130 140 150
QFDDYLALAR DANIRFMFSN TTEAGIAWNE ADQFSDAPPS SFPAKLTRLL
160 170 180 190 200
FERFEHFDGA ADKGWVLLPC ELIDYNGEAL RELVLRYASH WQLPAAFTHW
210 220 230 240 250
LTENNTFCST LVDRIVTGYP RDEVAALQTE LGYQDSFLDT AEYFYLFVIQ
260 270 280 290 300
GPQGLAQELR LDQLDLNVRI VDDIKPYKER KVAILNGAHT ALVPVAYLSG
310 320 330 340 350
LDTVGQTMDD AQISRFVEKT ITEEIVPVLD LPEDELLSFS QAVLSRFRNP
360 370 380 390 400
FIQHQLLSIA LNGMTKFRTR ILPQLLTYQQ QKGQLPPRLT FALAALIAFY
410 420 430 440 450
RGEREGQTYP LQDDAHWLER YSTLWNGVKH GDIALAELVN RVLSDANHWG
460 470 480
QDLTAVPQLA NQVTEQLQTI LSRGMRAAVA AYS
Length:483
Mass (Da):54,907
Last modified:March 1, 2002 - v1
Checksum:iBDDB13837F6564B4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti455A → S in AAS63082 (PubMed:15368893).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL19260.1
AE009952 Genomic DNA Translation: AAM87147.1
AE017042 Genomic DNA Translation: AAS63082.1
PIRiAB0072
RefSeqiWP_002210409.1, NZ_PDBR01000090.1
YP_002345652.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM87147; AAM87147; y3599
AAS63082; AAS63082; YP_2900
GeneIDi1173425
KEGGiype:YPO0580
ypj:CH55_2317
ypk:y3599
ypl:CH46_337
ypm:YP_2900
ypv:BZ15_2994
ypw:CH59_1284
PATRICifig|214092.21.peg.837

Similar proteinsi

Entry informationi

Entry nameiUXAB_YERPE
AccessioniPrimary (citable) accession number: Q8ZIC5
Secondary accession number(s): Q0WJ86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health