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Q8ZIC5 (UXAB_YERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Altronate oxidoreductase

EC=1.1.1.58
Alternative name(s):
Tagaturonate dehydrogenase
Tagaturonate reductase
Gene names
Name:uxaB
Ordered Locus Names:YPO0580, y3599, YP_2900
OrganismYersinia pestis [Reference proteome] [HAMAP]
Taxonomic identifier632 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-altronate + NAD+ = D-tagaturonate + NADH. HAMAP-Rule MF_00670

Pathway

Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP-Rule MF_00670

Sequence similarities

Belongs to the mannitol dehydrogenase family. UxaB subfamily.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

tagaturonate reductase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 483483Altronate oxidoreductase HAMAP-Rule MF_00670
PRO_0000170746

Regions

Nucleotide binding18 – 2912NAD By similarity

Experimental info

Sequence conflict4551A → S in AAS63082. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8ZIC5 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: BDDB13837F6564B4

FASTA48354,907
        10         20         30         40         50         60 
MQTLNRRDFP GRSHPDKIIQ FGEGNFLRAF VDWQIDLLNE HTDLNAGIVV IRPIDTDFPP 

        70         80         90        100        110        120 
SLSTQDGLYT AVIRGLNEQG EAVRESRLIR SVNREINIYR QFDDYLALAR DANIRFMFSN 

       130        140        150        160        170        180 
TTEAGIAWNE ADQFSDAPPS SFPAKLTRLL FERFEHFDGA ADKGWVLLPC ELIDYNGEAL 

       190        200        210        220        230        240 
RELVLRYASH WQLPAAFTHW LTENNTFCST LVDRIVTGYP RDEVAALQTE LGYQDSFLDT 

       250        260        270        280        290        300 
AEYFYLFVIQ GPQGLAQELR LDQLDLNVRI VDDIKPYKER KVAILNGAHT ALVPVAYLSG 

       310        320        330        340        350        360 
LDTVGQTMDD AQISRFVEKT ITEEIVPVLD LPEDELLSFS QAVLSRFRNP FIQHQLLSIA 

       370        380        390        400        410        420 
LNGMTKFRTR ILPQLLTYQQ QKGQLPPRLT FALAALIAFY RGEREGQTYP LQDDAHWLER 

       430        440        450        460        470        480 
YSTLWNGVKH GDIALAELVN RVLSDANHWG QDLTAVPQLA NQVTEQLQTI LSRGMRAAVA 


AYS 

« Hide

References

[1]"Genome sequence of Yersinia pestis, the causative agent of plague."
Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. expand/collapse author list , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.
Nature 413:523-527(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CO-92 / Biovar Orientalis.
[2]"Genome sequence of Yersinia pestis KIM."
Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. expand/collapse author list , Matson J.S., Blattner F.R., Perry R.D.
J. Bacteriol. 184:4601-4611(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KIM10+ / Biovar Mediaevalis.
[3]"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. expand/collapse author list , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL590842 Genomic DNA. Translation: CAL19260.1.
AE009952 Genomic DNA. Translation: AAM87147.1.
AE017042 Genomic DNA. Translation: AAS63082.1.
PIRAB0072.
RefSeqNP_670896.1. NC_004088.1.
NP_994205.1. NC_005810.1.
YP_002345652.1. NC_003143.1.

3D structure databases

ProteinModelPortalQ8ZIC5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8ZIC5. 2 interactions.
STRING214092.YPO0580.

Protocols and materials databases

DNASU1148546.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM87147; AAM87147; y3599.
AAS63082; AAS63082; YP_2900.
GeneID1148546.
1173425.
2763598.
KEGGype:YPO0580.
ypk:y3599.
ypm:YP_2900.

Phylogenomic databases

eggNOGCOG0246.
HOGENOMHOG000029586.
KOK00041.
OMAHNTFCST.
OrthoDBEOG6CVVB8.

Enzyme and pathway databases

BioCycYPES214092:GKDD-575-MONOMER.
UniPathwayUPA00246.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPMF_00670. Altron_oxidoreduct.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR023668. Altronate_OxRdtase.
IPR013328. DH_multihelical.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUXAB_YERPE
AccessionPrimary (citable) accession number: Q8ZIC5
Secondary accession number(s): Q0WJ86
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways