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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciYPES214092:GKDD-642-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Synonyms:bacA, upk
Ordered Locus Names:YPO0649, y3530, YP_2964
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815 Componenti: Chromosome UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalUniRule annotationAdd
BLAST
Transmembranei45 – 6521HelicalUniRule annotationAdd
BLAST
Transmembranei88 – 10821HelicalUniRule annotationAdd
BLAST
Transmembranei114 – 13421HelicalUniRule annotationAdd
BLAST
Transmembranei153 – 17220HelicalUniRule annotationAdd
BLAST
Transmembranei189 – 20921HelicalUniRule annotationAdd
BLAST
Transmembranei221 – 24121HelicalUniRule annotationAdd
BLAST
Transmembranei251 – 27121HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Undecaprenyl-diphosphatasePRO_0000151246Add
BLAST

Proteomic databases

PRIDEiQ8ZI65.

Interactioni

Protein-protein interaction databases

IntActiQ8ZI65. 1 interaction.
STRINGi214092.YPO0649.

Structurei

3D structure databases

ProteinModelPortaliQ8ZI65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiAQCFALI.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZI65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDMYSLFVA FILGVVEGLT EFLPVSSTGH MIIVGELLGF TGDKAKTFEV
60 70 80 90 100
IIQLGSILAV VVVFWRRLFG LIGIHFGAVP HEGKTNGHLT LGHILLAMIP
110 120 130 140 150
AVILGLAFHD VIKALFDPKS VMYALVAGGV LLLAAEWLKP KNPKAVGLDD
160 170 180 190 200
ITYRQAFAIG CFQCLALWPG FSRSGATISG GMLVGVNRYA ASEFSFILAV
210 220 230 240 250
PMMIGASGLD LYKSLHFLTL GDLPMFAVGF ITAFIVALIA IKTFLSLIKR
260 270
ISFVPFAIYR FIVAAVVYWV FM
Length:272
Mass (Da):29,483
Last modified:March 5, 2002 - v1
Checksum:i164FC644788F2189
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL19326.1.
AE009952 Genomic DNA. Translation: AAM87078.1.
AE017042 Genomic DNA. Translation: AAS63143.1.
PIRiAD0080.
RefSeqiNP_670827.1. NC_004088.1.
NP_994266.1. NC_005810.1.
WP_002212198.1. NZ_KN150725.1.
YP_002345717.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM87078; AAM87078; y3530.
AAS63143; AAS63143; YP_2964.
GeneIDi1173493.
KEGGiype:YPO0649.
ypk:y3530.
ypm:YP_2964.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL19326.1.
AE009952 Genomic DNA. Translation: AAM87078.1.
AE017042 Genomic DNA. Translation: AAS63143.1.
PIRiAD0080.
RefSeqiNP_670827.1. NC_004088.1.
NP_994266.1. NC_005810.1.
WP_002212198.1. NZ_KN150725.1.
YP_002345717.1. NC_003143.1.

3D structure databases

ProteinModelPortaliQ8ZI65.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8ZI65. 1 interaction.
STRINGi214092.YPO0649.

Proteomic databases

PRIDEiQ8ZI65.

Protocols and materials databases

DNASUi1148477.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM87078; AAM87078; y3530.
AAS63143; AAS63143; YP_2964.
GeneIDi1173493.
KEGGiype:YPO0649.
ypk:y3530.
ypm:YP_2964.

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiAQCFALI.
OrthoDBiEOG6QP13M.

Enzyme and pathway databases

BioCyciYPES214092:GKDD-642-MONOMER.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiUPPP_YERPE
AccessioniPrimary (citable) accession number: Q8ZI65
Secondary accession number(s): Q0WJ21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 5, 2002
Last modified: June 24, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.