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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation
  • pyridoxal 5'-phosphateUniRule annotation

Pathwayi

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. putrescine biosynthetic process Source: UniProtKB-HAMAP
  3. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciYPES214092:GKDD-914-MONOMER.
BRENDAi4.1.1.19. 4559.
UniPathwayiUPA00186; UER00284.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:YPO0929, y3313, YP_3513
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815 Componenti: Chromosome UP000001019 Componenti: Chromosome UP000002490 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 659659Biosynthetic arginine decarboxylasePRO_0000149991Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei128 – 1281N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiQ8ZHG8.

Interactioni

Protein-protein interaction databases

IntActiQ8ZHG8. 7 interactions.
STRINGi214092.YPO0929.

Structurei

3D structure databases

ProteinModelPortaliQ8ZHG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni308 – 31811Substrate-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiIDHYVDG.
OrthoDBiEOG676Z0R.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZHG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDDNLISRP LTAGAHVSLR SMQEVAMNDR NASKMLSTYN VAYWGGNYYD
60 70 80 90 100
VNELGHISVC PDPDIREARV DLAQLVKKMQ LEQGQRLPAL FCFPQILQHR
110 120 130 140 150
LRSINAAFKR ARESFGYEGG YFLVYPIKVN QHRRVIESLV NSGEPLGLEA
160 170 180 190 200
GSKAEMMAVL AHAGMTRSVI VCNGYKDREY IRLALIGEKL GHKVYLVIEK
210 220 230 240 250
MSEIKMVLEE AERLNVVPRL GVRARLASQG SGKWQASGGE KSKFGLSATQ
260 270 280 290 300
VLQLVDMLRE ANSLESLQLL HFHLGSQLSN IRDISTGVRE SARFYVELHK
310 320 330 340 350
LGVNIQCFDV GGGLGVDYEG TRSQSDCSVN YGLNEYANNV IWGIGDACNE
360 370 380 390 400
HGLPHPTVIT ESGRAVTAHH TVLVSNVIGV ERNEFCEPQP PEAGAPRALE
410 420 430 440 450
SLWDTWQEMQ EPENRRSLRE WLHDSQMDLH DVHTQYAHGM LDLTHRAWAE
460 470 480 490 500
QLYLSICNEI QKQLDPSNRA HRPIIDELQE RMADKLYVNF SLFQSMPDAW
510 520 530 540 550
GIDQLFPVLP LEGLDKPPER RAVLLDITCD SDGTIDHYID GDGVATTMPM
560 570 580 590 600
PPYDPENPPL LGFFMVGAYQ EILGNMHNLF GDTAAVDVYV FPDGTVEVEQ
610 620 630 640 650
TDEGDTVADM LEYVQLNPEK LLEHFRGQVK ETDLDTELQA QFLEEFEAGL

YGYTYLEDE
Length:659
Mass (Da):74,104
Last modified:February 28, 2002 - v1
Checksum:iAD2795F60745B686
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL19596.1.
AE009952 Genomic DNA. Translation: AAM86863.1.
AE017042 Genomic DNA. Translation: AAS63667.1.
PIRiAB0114.
RefSeqiNP_670612.1. NC_004088.1.
NP_994790.1. NC_005810.1.
YP_002345977.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM86863; AAM86863; y3313.
AAS63667; AAS63667; YP_3513.
GeneIDi1173766.
KEGGiype:YPO0929.
ypk:y3313.
ypm:YP_3513.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL19596.1.
AE009952 Genomic DNA. Translation: AAM86863.1.
AE017042 Genomic DNA. Translation: AAS63667.1.
PIRiAB0114.
RefSeqiNP_670612.1. NC_004088.1.
NP_994790.1. NC_005810.1.
YP_002345977.1. NC_003143.1.

3D structure databases

ProteinModelPortaliQ8ZHG8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8ZHG8. 7 interactions.
STRINGi214092.YPO0929.

Proteomic databases

PRIDEiQ8ZHG8.

Protocols and materials databases

DNASUi1148260.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM86863; AAM86863; y3313.
AAS63667; AAS63667; YP_3513.
GeneIDi1173766.
KEGGiype:YPO0929.
ypk:y3313.
ypm:YP_3513.

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiIDHYVDG.
OrthoDBiEOG676Z0R.

Enzyme and pathway databases

UniPathwayiUPA00186; UER00284.
BioCyciYPES214092:GKDD-914-MONOMER.
BRENDAi4.1.1.19. 4559.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiSPEA_YERPE
AccessioniPrimary (citable) accession number: Q8ZHG8
Secondary accession number(s): Q0WIB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2004
Last sequence update: February 28, 2002
Last modified: March 31, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.