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Q8ZHG8 (SPEA_YERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Biosynthetic arginine decarboxylase

Short name=ADC
EC=4.1.1.19
Gene names
Name:speA
Ordered Locus Names:YPO0929, y3313, YP_3513
OrganismYersinia pestis [Reference proteome] [HAMAP]
Taxonomic identifier632 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length659 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP-Rule MF_01417

Catalytic activity

L-arginine = agmatine + CO2. HAMAP-Rule MF_01417

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01417

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01417

Pathway

Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. HAMAP-Rule MF_01417

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 659659Biosynthetic arginine decarboxylase HAMAP-Rule MF_01417
PRO_0000149991

Regions

Region308 – 31811Substrate-binding Potential

Amino acid modifications

Modified residue1281N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8ZHG8 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: AD2795F60745B686

FASTA65974,104
        10         20         30         40         50         60 
MSDDNLISRP LTAGAHVSLR SMQEVAMNDR NASKMLSTYN VAYWGGNYYD VNELGHISVC 

        70         80         90        100        110        120 
PDPDIREARV DLAQLVKKMQ LEQGQRLPAL FCFPQILQHR LRSINAAFKR ARESFGYEGG 

       130        140        150        160        170        180 
YFLVYPIKVN QHRRVIESLV NSGEPLGLEA GSKAEMMAVL AHAGMTRSVI VCNGYKDREY 

       190        200        210        220        230        240 
IRLALIGEKL GHKVYLVIEK MSEIKMVLEE AERLNVVPRL GVRARLASQG SGKWQASGGE 

       250        260        270        280        290        300 
KSKFGLSATQ VLQLVDMLRE ANSLESLQLL HFHLGSQLSN IRDISTGVRE SARFYVELHK 

       310        320        330        340        350        360 
LGVNIQCFDV GGGLGVDYEG TRSQSDCSVN YGLNEYANNV IWGIGDACNE HGLPHPTVIT 

       370        380        390        400        410        420 
ESGRAVTAHH TVLVSNVIGV ERNEFCEPQP PEAGAPRALE SLWDTWQEMQ EPENRRSLRE 

       430        440        450        460        470        480 
WLHDSQMDLH DVHTQYAHGM LDLTHRAWAE QLYLSICNEI QKQLDPSNRA HRPIIDELQE 

       490        500        510        520        530        540 
RMADKLYVNF SLFQSMPDAW GIDQLFPVLP LEGLDKPPER RAVLLDITCD SDGTIDHYID 

       550        560        570        580        590        600 
GDGVATTMPM PPYDPENPPL LGFFMVGAYQ EILGNMHNLF GDTAAVDVYV FPDGTVEVEQ 

       610        620        630        640        650 
TDEGDTVADM LEYVQLNPEK LLEHFRGQVK ETDLDTELQA QFLEEFEAGL YGYTYLEDE 

« Hide

References

[1]"Genome sequence of Yersinia pestis, the causative agent of plague."
Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. expand/collapse author list , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.
Nature 413:523-527(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CO-92 / Biovar Orientalis.
[2]"Genome sequence of Yersinia pestis KIM."
Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. expand/collapse author list , Matson J.S., Blattner F.R., Perry R.D.
J. Bacteriol. 184:4601-4611(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KIM10+ / Biovar Mediaevalis.
[3]"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. expand/collapse author list , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 91001 / Biovar Mediaevalis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL590842 Genomic DNA. Translation: CAL19596.1.
AE009952 Genomic DNA. Translation: AAM86863.1.
AE017042 Genomic DNA. Translation: AAS63667.1.
PIRAB0114.
RefSeqNP_670612.1. NC_004088.1.
NP_994790.1. NC_005810.1.
YP_002345977.1. NC_003143.1.

3D structure databases

ProteinModelPortalQ8ZHG8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8ZHG8. 7 interactions.
STRING214092.YPO0929.

Proteomic databases

PRIDEQ8ZHG8.

Protocols and materials databases

DNASU1148260.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM86863; AAM86863; y3313.
AAS63667; AAS63667; YP_3513.
GeneID1148260.
1173766.
2764242.
KEGGype:YPO0929.
ypk:y3313.
ypm:YP_3513.

Phylogenomic databases

eggNOGCOG1166.
HOGENOMHOG000029191.
KOK01585.
OMAIDHYVDG.
OrthoDBEOG676Z0R.

Enzyme and pathway databases

BioCycYPES214092:GKDD-914-MONOMER.
BRENDA4.1.1.19. 6743.
UniPathwayUPA00186; UER00284.

Family and domain databases

Gene3D2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPMF_01417. SpeA.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR01273. speA. 1 hit.
PROSITEPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSPEA_YERPE
AccessionPrimary (citable) accession number: Q8ZHG8
Secondary accession number(s): Q0WIB1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 1, 2002
Last modified: June 11, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways