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Q8ZHG8

- SPEA_YERPE

UniProt

Q8ZHG8 - SPEA_YERPE

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Protein
Biosynthetic arginine decarboxylase
Gene
speA, YPO0929, y3313, YP_3513
Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine By similarity.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation
Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. putrescine biosynthetic process Source: UniProtKB-HAMAP
  3. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciYPES214092:GKDD-914-MONOMER.
BRENDAi4.1.1.19. 6743.
UniPathwayiUPA00186; UER00284.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylase (EC:4.1.1.19)
Short name:
ADC
Gene namesi
Name:speA
Ordered Locus Names:YPO0929, y3313, YP_3513
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 659659Biosynthetic arginine decarboxylaseUniRule annotation
PRO_0000149991Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei128 – 1281N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiQ8ZHG8.

Interactioni

Protein-protein interaction databases

IntActiQ8ZHG8. 7 interactions.
STRINGi214092.YPO0929.

Structurei

3D structure databases

ProteinModelPortaliQ8ZHG8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni308 – 31811Substrate-binding Reviewed prediction
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiIDHYVDG.
OrthoDBiEOG676Z0R.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZHG8-1 [UniParc]FASTAAdd to Basket

« Hide

MSDDNLISRP LTAGAHVSLR SMQEVAMNDR NASKMLSTYN VAYWGGNYYD    50
VNELGHISVC PDPDIREARV DLAQLVKKMQ LEQGQRLPAL FCFPQILQHR 100
LRSINAAFKR ARESFGYEGG YFLVYPIKVN QHRRVIESLV NSGEPLGLEA 150
GSKAEMMAVL AHAGMTRSVI VCNGYKDREY IRLALIGEKL GHKVYLVIEK 200
MSEIKMVLEE AERLNVVPRL GVRARLASQG SGKWQASGGE KSKFGLSATQ 250
VLQLVDMLRE ANSLESLQLL HFHLGSQLSN IRDISTGVRE SARFYVELHK 300
LGVNIQCFDV GGGLGVDYEG TRSQSDCSVN YGLNEYANNV IWGIGDACNE 350
HGLPHPTVIT ESGRAVTAHH TVLVSNVIGV ERNEFCEPQP PEAGAPRALE 400
SLWDTWQEMQ EPENRRSLRE WLHDSQMDLH DVHTQYAHGM LDLTHRAWAE 450
QLYLSICNEI QKQLDPSNRA HRPIIDELQE RMADKLYVNF SLFQSMPDAW 500
GIDQLFPVLP LEGLDKPPER RAVLLDITCD SDGTIDHYID GDGVATTMPM 550
PPYDPENPPL LGFFMVGAYQ EILGNMHNLF GDTAAVDVYV FPDGTVEVEQ 600
TDEGDTVADM LEYVQLNPEK LLEHFRGQVK ETDLDTELQA QFLEEFEAGL 650
YGYTYLEDE 659
Length:659
Mass (Da):74,104
Last modified:March 1, 2002 - v1
Checksum:iAD2795F60745B686
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL19596.1.
AE009952 Genomic DNA. Translation: AAM86863.1.
AE017042 Genomic DNA. Translation: AAS63667.1.
PIRiAB0114.
RefSeqiNP_670612.1. NC_004088.1.
NP_994790.1. NC_005810.1.
YP_002345977.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM86863; AAM86863; y3313.
AAS63667; AAS63667; YP_3513.
GeneIDi1148260.
1173766.
2764242.
KEGGiype:YPO0929.
ypk:y3313.
ypm:YP_3513.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL19596.1 .
AE009952 Genomic DNA. Translation: AAM86863.1 .
AE017042 Genomic DNA. Translation: AAS63667.1 .
PIRi AB0114.
RefSeqi NP_670612.1. NC_004088.1.
NP_994790.1. NC_005810.1.
YP_002345977.1. NC_003143.1.

3D structure databases

ProteinModelPortali Q8ZHG8.
ModBasei Search...

Protein-protein interaction databases

IntActi Q8ZHG8. 7 interactions.
STRINGi 214092.YPO0929.

Proteomic databases

PRIDEi Q8ZHG8.

Protocols and materials databases

DNASUi 1148260.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM86863 ; AAM86863 ; y3313 .
AAS63667 ; AAS63667 ; YP_3513 .
GeneIDi 1148260.
1173766.
2764242.
KEGGi ype:YPO0929.
ypk:y3313.
ypm:YP_3513.

Phylogenomic databases

eggNOGi COG1166.
HOGENOMi HOG000029191.
KOi K01585.
OMAi IDHYVDG.
OrthoDBi EOG676Z0R.

Enzyme and pathway databases

UniPathwayi UPA00186 ; UER00284 .
BioCyci YPES214092:GKDD-914-MONOMER.
BRENDAi 4.1.1.19. 6743.

Family and domain databases

Gene3Di 2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPi MF_01417. SpeA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSi PR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01273. speA. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiSPEA_YERPE
AccessioniPrimary (citable) accession number: Q8ZHG8
Secondary accession number(s): Q0WIB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 1, 2002
Last modified: June 11, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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