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Q8ZHF1

- GLSA1_YERPE

UniProt

Q8ZHF1 - GLSA1_YERPE

Protein

Glutaminase 1

Gene

glsA1

Organism
Yersinia pestis
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei66 – 661SubstrateUniRule annotation
    Binding sitei117 – 1171SubstrateUniRule annotation
    Binding sitei161 – 1611SubstrateUniRule annotation
    Binding sitei168 – 1681SubstrateUniRule annotation
    Binding sitei192 – 1921SubstrateUniRule annotation
    Binding sitei244 – 2441SubstrateUniRule annotation
    Binding sitei262 – 2621Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. glutaminase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciYPES214092:GKDD-933-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutaminase 1UniRule annotation (EC:3.5.1.2UniRule annotation)
    Gene namesi
    Name:glsA1UniRule annotation
    Ordered Locus Names:YPO0949, y3336, YP_3492
    OrganismiYersinia pestis
    Taxonomic identifieri632 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 308308Glutaminase 1PRO_0000110633Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    IntActiQ8ZHF1. 5 interactions.
    STRINGi214092.YPO0949.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8ZHF1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutaminase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2066.
    HOGENOMiHOG000216890.
    KOiK01425.
    OMAiIVPDELC.
    OrthoDBiEOG6N94BK.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    HAMAPiMF_00313. Glutaminase.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view]
    PANTHERiPTHR12544. PTHR12544. 1 hit.
    PfamiPF04960. Glutaminase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8ZHF1-1 [UniParc]FASTAAdd to Basket

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    MVTTLDNALL NDILQQVRPL IGQGKVADYI PALAEVPANK LGIAVCTLDG    50
    QIFQAGDADE RFSIQSISKV LSLTLALSRY SEQDIWQRVG KEPSGQPFNS 100
    LVQLELEKGK PRNPFINLGA LVVCDMLQSR LSAPKQRLLE VVRQLVKDDS 150
    ISYDPRVARS EFEHSDRNAA IAYLMKSFGN FDNDVLTVLQ TYFHYCAMRM 200
    SCVELARCFV YLANQGRSIS GSESLITPMQ ARQINALMIT SGMYDGAGEF 250
    AFRVGMPGKS GVGGGIIAIV PDEFCIAVWS PELDHAGNSL AGTAALERLA 300
    QQMGRSIF 308
    Length:308
    Mass (Da):33,700
    Last modified:March 1, 2002 - v1
    Checksum:iD80AD7C77F23FEC3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL19615.1.
    AE009952 Genomic DNA. Translation: AAM86886.1.
    AE017042 Genomic DNA. Translation: AAS63647.1.
    PIRiAE0116.
    RefSeqiNP_670635.1. NC_004088.1.
    NP_994770.1. NC_005810.1.
    YP_002345995.1. NC_003143.1.

    Genome annotation databases

    EnsemblBacteriaiAAM86886; AAM86886; y3336.
    AAS63647; AAS63647; YP_3492.
    GeneIDi1148283.
    1173785.
    2765271.
    KEGGiype:YPO0949.
    ypk:y3336.
    ypm:YP_3492.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL19615.1 .
    AE009952 Genomic DNA. Translation: AAM86886.1 .
    AE017042 Genomic DNA. Translation: AAS63647.1 .
    PIRi AE0116.
    RefSeqi NP_670635.1. NC_004088.1.
    NP_994770.1. NC_005810.1.
    YP_002345995.1. NC_003143.1.

    3D structure databases

    ProteinModelPortali Q8ZHF1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8ZHF1. 5 interactions.
    STRINGi 214092.YPO0949.

    Protocols and materials databases

    DNASUi 1148283.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM86886 ; AAM86886 ; y3336 .
    AAS63647 ; AAS63647 ; YP_3492 .
    GeneIDi 1148283.
    1173785.
    2765271.
    KEGGi ype:YPO0949.
    ypk:y3336.
    ypm:YP_3492.

    Phylogenomic databases

    eggNOGi COG2066.
    HOGENOMi HOG000216890.
    KOi K01425.
    OMAi IVPDELC.
    OrthoDBi EOG6N94BK.

    Enzyme and pathway databases

    BioCyci YPES214092:GKDD-933-MONOMER.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    HAMAPi MF_00313. Glutaminase.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view ]
    PANTHERi PTHR12544. PTHR12544. 1 hit.
    Pfami PF04960. Glutaminase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CO-92 / Biovar Orientalis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIM10+ / Biovar Mediaevalis.
    3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
      Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
      , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
      DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 91001 / Biovar Mediaevalis.

    Entry informationi

    Entry nameiGLSA1_YERPE
    AccessioniPrimary (citable) accession number: Q8ZHF1
    Secondary accession number(s): Q0WI93
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3