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Q8ZHF1

- GLSA1_YERPE

UniProt

Q8ZHF1 - GLSA1_YERPE

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Protein
Glutaminase 1
Gene
glsA1, YPO0949, y3336, YP_3492
Organism
Yersinia pestis
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei66 – 661Substrate By similarity
Binding sitei117 – 1171Substrate By similarity
Binding sitei161 – 1611Substrate By similarity
Binding sitei168 – 1681Substrate By similarity
Binding sitei192 – 1921Substrate By similarity
Binding sitei244 – 2441Substrate By similarity
Binding sitei262 – 2621Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciYPES214092:GKDD-933-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase 1 (EC:3.5.1.2)
Gene namesi
Name:glsA1
Ordered Locus Names:YPO0949, y3336, YP_3492
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Glutaminase 1UniRule annotation
PRO_0000110633Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

IntActiQ8ZHF1. 5 interactions.
STRINGi214092.YPO0949.

Structurei

3D structure databases

ProteinModelPortaliQ8ZHF1.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiIVPDELC.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZHF1-1 [UniParc]FASTAAdd to Basket

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MVTTLDNALL NDILQQVRPL IGQGKVADYI PALAEVPANK LGIAVCTLDG    50
QIFQAGDADE RFSIQSISKV LSLTLALSRY SEQDIWQRVG KEPSGQPFNS 100
LVQLELEKGK PRNPFINLGA LVVCDMLQSR LSAPKQRLLE VVRQLVKDDS 150
ISYDPRVARS EFEHSDRNAA IAYLMKSFGN FDNDVLTVLQ TYFHYCAMRM 200
SCVELARCFV YLANQGRSIS GSESLITPMQ ARQINALMIT SGMYDGAGEF 250
AFRVGMPGKS GVGGGIIAIV PDEFCIAVWS PELDHAGNSL AGTAALERLA 300
QQMGRSIF 308
Length:308
Mass (Da):33,700
Last modified:March 1, 2002 - v1
Checksum:iD80AD7C77F23FEC3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL19615.1.
AE009952 Genomic DNA. Translation: AAM86886.1.
AE017042 Genomic DNA. Translation: AAS63647.1.
PIRiAE0116.
RefSeqiNP_670635.1. NC_004088.1.
NP_994770.1. NC_005810.1.
YP_002345995.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM86886; AAM86886; y3336.
AAS63647; AAS63647; YP_3492.
GeneIDi1148283.
1173785.
2765271.
KEGGiype:YPO0949.
ypk:y3336.
ypm:YP_3492.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL19615.1 .
AE009952 Genomic DNA. Translation: AAM86886.1 .
AE017042 Genomic DNA. Translation: AAS63647.1 .
PIRi AE0116.
RefSeqi NP_670635.1. NC_004088.1.
NP_994770.1. NC_005810.1.
YP_002345995.1. NC_003143.1.

3D structure databases

ProteinModelPortali Q8ZHF1.
ModBasei Search...

Protein-protein interaction databases

IntActi Q8ZHF1. 5 interactions.
STRINGi 214092.YPO0949.

Protocols and materials databases

DNASUi 1148283.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM86886 ; AAM86886 ; y3336 .
AAS63647 ; AAS63647 ; YP_3492 .
GeneIDi 1148283.
1173785.
2765271.
KEGGi ype:YPO0949.
ypk:y3336.
ypm:YP_3492.

Phylogenomic databases

eggNOGi COG2066.
HOGENOMi HOG000216890.
KOi K01425.
OMAi IVPDELC.
OrthoDBi EOG6N94BK.

Enzyme and pathway databases

BioCyci YPES214092:GKDD-933-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiGLSA1_YERPE
AccessioniPrimary (citable) accession number: Q8ZHF1
Secondary accession number(s): Q0WI93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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