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Protein

Membrane-bound lytic murein transglycosylase C

Gene

mltC

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.UniRule annotation

Catalytic activityi

Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Cell wall biogenesis/degradation

Protein family/group databases

CAZyiGH23. Glycoside Hydrolase Family 23.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-bound lytic murein transglycosylase CUniRule annotation (EC:4.2.2.n1UniRule annotation)
Alternative name(s):
Murein lyase CUniRule annotation
Gene namesi
Name:mltCUniRule annotation
Ordered Locus Names:YPO0954, y3341, YP_3487
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cell outer membrane UniRule annotation; Lipid-anchor UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616UniRule annotationAdd
BLAST
Chaini17 – 358342Membrane-bound lytic murein transglycosylase CPRO_0000032799Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi17 – 171N-palmitoyl cysteineUniRule annotation
Lipidationi17 – 171S-diacylglycerol cysteineUniRule annotation

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

IntActiQ8ZHE6. 1 interaction.
STRINGi187410.y3341.

Structurei

3D structure databases

ProteinModelPortaliQ8ZHE6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transglycosylase Slt family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4106S48. Bacteria.
COG0741. LUCA.
HOGENOMiHOG000283572.
KOiK08306.
OMAiAIMQIES.
OrthoDBiEOG6Z0Q66.

Family and domain databases

HAMAPiMF_01616. MltC.
InterProiIPR023346. Lysozyme-like_dom.
IPR023664. Murein_transglycosylaseC.
IPR024570. Murein_transglycosylaseC_N.
IPR000189. Transglyc_AS.
IPR008258. Transglycosylase_SLT_dom_1.
[Graphical view]
PfamiPF11873. DUF3393. 1 hit.
PF01464. SLT. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS00922. TRANSGLYCOSYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8ZHE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKILALLVI APLLVSCSGN KNQVENEVFV KDTNGFEILM GQFAHNIENI
60 70 80 90 100
WGLKEVLIAG PKDYVKYTDQ YQTRSHINFD AGTITIETIA TTNPAAHLRQ
110 120 130 140 150
AIITTLLMGD DPGSIDLYSD VNDIQISKEP FLYGQVLDNN GEPIRWEWRA
160 170 180 190 200
AHFADYLLQN KMQTRTSGLH VISFVTIQLV PNHLDKRAHK YLPLVRKSAA
210 220 230 240 250
RYGVEESLIL AIMQTESSFN PYAVSRSDAL GLMQVVQHTA GKDVFKLKGK
260 270 280 290 300
SGQPSRSYLF DPENNIDAGT AYLSILQNTY LGGIQNATSR RYAVITSYNG
310 320 330 340 350
GAGSVLRVFH SDKNKAVGII NTMSPGDVFQ TLTTKHPSGE SRRYLVKVNS

AQKNYRRY
Length:358
Mass (Da):39,947
Last modified:July 19, 2005 - v2
Checksum:iDA79BBFD6951C952
GO

Sequence cautioni

The sequence AAM86891.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAS63642.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAL19620.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL19620.1. Different initiation.
AE009952 Genomic DNA. Translation: AAM86891.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS63642.1. Different initiation.
PIRiAB0117.
RefSeqiWP_002209995.1. NZ_LIXY01000003.1.

Genome annotation databases

EnsemblBacteriaiAAM86891; AAM86891; y3341.
AAS63642; AAS63642; YP_3487.
KEGGiypj:CH55_3587.
ypk:y3341.
ypl:CH46_4192.
ypm:YP_3487.
ypv:BZ15_2620.
ypw:CH59_911.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL19620.1. Different initiation.
AE009952 Genomic DNA. Translation: AAM86891.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS63642.1. Different initiation.
PIRiAB0117.
RefSeqiWP_002209995.1. NZ_LIXY01000003.1.

3D structure databases

ProteinModelPortaliQ8ZHE6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8ZHE6. 1 interaction.
STRINGi187410.y3341.

Protein family/group databases

CAZyiGH23. Glycoside Hydrolase Family 23.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM86891; AAM86891; y3341.
AAS63642; AAS63642; YP_3487.
KEGGiypj:CH55_3587.
ypk:y3341.
ypl:CH46_4192.
ypm:YP_3487.
ypv:BZ15_2620.
ypw:CH59_911.

Phylogenomic databases

eggNOGiENOG4106S48. Bacteria.
COG0741. LUCA.
HOGENOMiHOG000283572.
KOiK08306.
OMAiAIMQIES.
OrthoDBiEOG6Z0Q66.

Family and domain databases

HAMAPiMF_01616. MltC.
InterProiIPR023346. Lysozyme-like_dom.
IPR023664. Murein_transglycosylaseC.
IPR024570. Murein_transglycosylaseC_N.
IPR000189. Transglyc_AS.
IPR008258. Transglycosylase_SLT_dom_1.
[Graphical view]
PfamiPF11873. DUF3393. 1 hit.
PF01464. SLT. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS00922. TRANSGLYCOSYLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiMLTC_YERPE
AccessioniPrimary (citable) accession number: Q8ZHE6
Secondary accession number(s): Q0WI88, Q74QI2, Q7CGR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: May 11, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.