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Q8ZH86 (ARGA_YERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Amino-acid acetyltransferase
EC=2.3.1.1
Alternative name(s):
N-acetylglutamate synthase
Short name=AGS
Short name=NAGS
Gene names
Name:argA
Ordered Locus Names:YPO1022, y3162, YP_2828
OrganismYersinia pestis
Taxonomic identifier632 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length441 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate. HAMAP MF_01105

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4. HAMAP MF_01105

Subunit structure

Homohexamer Probable.

Subcellular location

Cytoplasm Probable HAMAP MF_01105.

Sequence similarities

Belongs to the acetyltransferase family. ArgA subfamily.

Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionacetyl-CoA:L-glutamate N-acetyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 441441Amino-acid acetyltransferase HAMAP MF_01105
PRO_0000186812

Regions

Domain295 – 434140N-acetyltransferase

Experimental info

Sequence conflict431 – 44111QRRSKILLADL → CNERCNSDPHPTPEIRSRG in AAS63012. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8ZH86 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: EBDC58CA73BC1960

FASTA44149,355
        10         20         30         40         50         60 
MKERSTELVQ GFRHSVPYIN AHRGKTFVVM LGGEAIEHEN FSSIVNDIGL LHSLGIRLVV 

        70         80         90        100        110        120 
VYGARPQIDS NLADHNYEPI YHKHTRVTDA RTLEMVKQAA GLLQLDITAR LSMSLNNTPL 

       130        140        150        160        170        180 
QGAHINVVSG NFIIAQPLGV DDGVDYCHSG RIRRIDEEAI HRQLDNGAIV LLGPVAVSVT 

       190        200        210        220        230        240 
GESFNLTSEE VATQLAIKLK AEKMIGFCSS QGVTDSEGNI ISELFPNDAQ KRIEDLEQDG 

       250        260        270        280        290        300 
DYNSGTVRFL RGAVKACRSG VRRSHLLSYQ EDGALIQELF SRDGIGTQIV MESAEQVRRA 

       310        320        330        340        350        360 
TINDIGGILE LIRPLEQQGI LVRRSREQLE MEIDKFTIIE RDNLTIACAA LYPFPDEHIG 

       370        380        390        400        410        420 
EMACVAVHPD YRSSSRGEML LNRITNQARQ MGLKKLFVLT TRSIHWFQER GFTPAEVDVL 

       430        440 
PIQKQELYNY QRRSKILLAD L

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References

[1]"Genome sequence of Yersinia pestis, the causative agent of plague."
Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. expand/collapse author list , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.
Nature 413:523-527(2001) [PubMed: 11586360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CO-92 / Biovar Orientalis.
[2]"Genome sequence of Yersinia pestis KIM."
Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. expand/collapse author list , Matson J.S., Blattner F.R., Perry R.D.
J. Bacteriol. 184:4601-4611(2002) [PubMed: 12142430] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KIM5 / Biovar Mediaevalis.
[3]"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. expand/collapse author list , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
DNA Res. 11:179-197(2004) [PubMed: 15368893] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL590842 Genomic DNA. Translation: CAL19688.1.
AE009952 Genomic DNA. Translation: AAM86712.1.
AE017042 Genomic DNA. Translation: AAS63012.1.
PIRAF0125.
RefSeqNP_670461.1. NC_004088.1.
NP_994135.1. NC_005810.1.
YP_002346066.1. NC_003143.1.

3D structure databases

ProteinModelPortalQ8ZH86.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1148109.
1173860.
2765021.
GenomeReviewsGene locus y3162 in contig AE009952_GR.
Gene locus YP_2828 in contig AE017042_GR.
Gene locus YPO1022 in contig AL590842_GR.
KEGGype:YPO1022.
ypk:y3162.
ypm:YP_2828.

Phylogenomic databases

HOGENOMHBG545264.
OMAAFNLAME.
ProtClustDBPRK05279.

Enzyme and pathway databases

BioCycYPES187410:Y3162-MONOMER.
YPES214092:YPO1022-MONOMER.

Family and domain databases

HAMAPMF_01105. N-acetyl_glu_synth.
[Tree]
InterProIPR000182. AcTrfase_GCN5-related_dom.
IPR016181. Acyl_CoA_acyltransferase.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR010167. NH2A_AcTrfase_ArgA.
[Graphical view]
Gene3DG3DSA:3.40.1160.10. Aa_kinase. 1 hit.
G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
KOK14682.
PfamPF00696. AA_kinase. 1 hit.
PF00583. Acetyltransf_1. 1 hit.
[Graphical view]
PIRSFPIRSF000423. ArgA. 1 hit.
SUPFAMSSF53633. Aa_kinase. 1 hit.
SSF55729. Acyl_CoA_acyltransferase. 1 hit.
TIGRFAMsTIGR01890. N-Ac-Glu-synth. 1 hit.
PROSITEPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARGA_YERPE
AccessionPrimary (citable) accession number: Q8ZH86
Secondary accession number(s): Q0WI22
Entry history
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: March 1, 2002
Last modified: December 14, 2011
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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