Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribosomal RNA large subunit methyltransferase M

Gene

rlmM

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + cytidine(2498) in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine(2498) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei189S-adenosyl-L-methionineUniRule annotation1
Binding sitei241S-adenosyl-L-methionineUniRule annotation1
Binding sitei261S-adenosyl-L-methionineUniRule annotation1
Binding sitei278S-adenosyl-L-methionineUniRule annotation1
Active sitei307Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase MUniRule annotation (EC:2.1.1.186UniRule annotation)
Alternative name(s):
23S rRNA (cytidine2498-2'-O)-methyltransferaseUniRule annotation
23S rRNA 2'-O-ribose methyltransferase RlmMUniRule annotation
Gene namesi
Name:rlmMUniRule annotation
Ordered Locus Names:YPO1031, y3152, YP_2820
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000704391 – 368Ribosomal RNA large subunit methyltransferase MAdd BLAST368

Proteomic databases

PRIDEiQ8ZH78.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi187410.y3152.

Structurei

3D structure databases

ProteinModelPortaliQ8ZH78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni222 – 225S-adenosyl-L-methionine bindingUniRule annotation4

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EZ6. Bacteria.
COG2933. LUCA.
HOGENOMiHOG000247137.
KOiK06968.
OMAiVIFECYQ.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01551. 23SrRNA_methyltr_M. 1 hit.
InterProiIPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR011224. rRNA_MeTrfase_M.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01728. FtsJ. 1 hit.
[Graphical view]
PIRSFiPIRSF028774. UCP028774. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZH78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNKIALYCR SGFEKECAAE ITEKAAQLEI FGFARVKENS GYVLFECYQL
60 70 80 90 100
EDADRLIREI PFREFIFARQ MMVVGELLKD LPPEDRVSPI VGMLVGVIEK
110 120 130 140 150
AGELRVEVAD TNESKELLKF CRKLTVPLRS ALREQKILSA RENAHRPVVH
160 170 180 190 200
VFFIAPGCCY VGYSYSNNNS PFYMGIPRLK FPSDAPSRST LKLEEAFHVF
210 220 230 240 250
IPADEWEERL ASGMHAVDLG ACPGGWTYQL VQRSMMIQAV DNGLMAQSLM
260 270 280 290 300
DTGQVTHHRA DGFKYEPTRS NIYWLVCDMV EKPTKVTQLI TKWLVNGWCR
310 320 330 340 350
EAIFNLKLPM KKRYEEVVQN LAMMDEQLKE NGINADIHAK QLYHDREEVT
360
VHVRRIWSGA PGRRDERY
Length:368
Mass (Da):42,307
Last modified:March 1, 2002 - v1
Checksum:iCE16B071F3203D2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL19696.1.
AE009952 Genomic DNA. Translation: AAM86702.1.
AE017042 Genomic DNA. Translation: AAS63004.1.
PIRiAF0126.
RefSeqiWP_002212119.1. NZ_LQBA01000126.1.
YP_002346074.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM86702; AAM86702; y3152.
AAS63004; AAS63004; YP_2820.
GeneIDi1173870.
KEGGiype:YPO1031.
ypk:y3152.
ypm:YP_2820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL19696.1.
AE009952 Genomic DNA. Translation: AAM86702.1.
AE017042 Genomic DNA. Translation: AAS63004.1.
PIRiAF0126.
RefSeqiWP_002212119.1. NZ_LQBA01000126.1.
YP_002346074.1. NC_003143.1.

3D structure databases

ProteinModelPortaliQ8ZH78.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187410.y3152.

Proteomic databases

PRIDEiQ8ZH78.

Protocols and materials databases

DNASUi1148099.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM86702; AAM86702; y3152.
AAS63004; AAS63004; YP_2820.
GeneIDi1173870.
KEGGiype:YPO1031.
ypk:y3152.
ypm:YP_2820.

Phylogenomic databases

eggNOGiENOG4105EZ6. Bacteria.
COG2933. LUCA.
HOGENOMiHOG000247137.
KOiK06968.
OMAiVIFECYQ.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01551. 23SrRNA_methyltr_M. 1 hit.
InterProiIPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR011224. rRNA_MeTrfase_M.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01728. FtsJ. 1 hit.
[Graphical view]
PIRSFiPIRSF028774. UCP028774. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRLMM_YERPE
AccessioniPrimary (citable) accession number: Q8ZH78
Secondary accession number(s): Q0WI14, Q74S37, Q7CH06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.