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Protein

Ribosomal RNA large subunit methyltransferase M

Gene

rlmM

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + cytidine(2498) in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine(2498) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei189S-adenosyl-L-methionineUniRule annotation1
Binding sitei241S-adenosyl-L-methionineUniRule annotation1
Binding sitei261S-adenosyl-L-methionineUniRule annotation1
Binding sitei278S-adenosyl-L-methionineUniRule annotation1
Active sitei307Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase MUniRule annotation (EC:2.1.1.186UniRule annotation)
Alternative name(s):
23S rRNA (cytidine2498-2'-O)-methyltransferaseUniRule annotation
23S rRNA 2'-O-ribose methyltransferase RlmMUniRule annotation
Gene namesi
Name:rlmMUniRule annotation
Ordered Locus Names:YPO1031, y3152, YP_2820
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000704391 – 368Ribosomal RNA large subunit methyltransferase MAdd BLAST368

Proteomic databases

PaxDbiQ8ZH78
PRIDEiQ8ZH78

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi187410.y3152

Structurei

3D structure databases

ProteinModelPortaliQ8ZH78
SMRiQ8ZH78
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni222 – 225S-adenosyl-L-methionine bindingUniRule annotation4

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EZ6 Bacteria
COG2933 LUCA
HOGENOMiHOG000247137
KOiK06968
OMAiPVDWMVC

Family and domain databases

HAMAPiMF_01551 23SrRNA_methyltr_M, 1 hit
InterProiView protein in InterPro
IPR002877 rRNA_MeTrfase_FtsJ_dom
IPR011224 rRNA_MeTrfase_M
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF01728 FtsJ, 1 hit
PIRSFiPIRSF028774 UCP028774, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZH78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNKIALYCR SGFEKECAAE ITEKAAQLEI FGFARVKENS GYVLFECYQL
60 70 80 90 100
EDADRLIREI PFREFIFARQ MMVVGELLKD LPPEDRVSPI VGMLVGVIEK
110 120 130 140 150
AGELRVEVAD TNESKELLKF CRKLTVPLRS ALREQKILSA RENAHRPVVH
160 170 180 190 200
VFFIAPGCCY VGYSYSNNNS PFYMGIPRLK FPSDAPSRST LKLEEAFHVF
210 220 230 240 250
IPADEWEERL ASGMHAVDLG ACPGGWTYQL VQRSMMIQAV DNGLMAQSLM
260 270 280 290 300
DTGQVTHHRA DGFKYEPTRS NIYWLVCDMV EKPTKVTQLI TKWLVNGWCR
310 320 330 340 350
EAIFNLKLPM KKRYEEVVQN LAMMDEQLKE NGINADIHAK QLYHDREEVT
360
VHVRRIWSGA PGRRDERY
Length:368
Mass (Da):42,307
Last modified:March 1, 2002 - v1
Checksum:iCE16B071F3203D2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL19696.1
AE009952 Genomic DNA Translation: AAM86702.1
AE017042 Genomic DNA Translation: AAS63004.1
PIRiAF0126
RefSeqiWP_002212119.1, NZ_PDBR01000013.1
YP_002346074.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM86702; AAM86702; y3152
AAS63004; AAS63004; YP_2820
GeneIDi1173870
KEGGiype:YPO1031
ypk:y3152
ypm:YP_2820
PATRICifig|214092.21.peg.1319

Similar proteinsi

Entry informationi

Entry nameiRLMM_YERPE
AccessioniPrimary (citable) accession number: Q8ZH78
Secondary accession number(s): Q0WI14, Q74S37, Q7CH06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health