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Protein

Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene

lpxA

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine.UniRule annotation

Pathwayi: lipid IV(A) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA), Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA)
  2. UDP-3-O-acyl-N-acetylglucosamine deacetylase (lpxC), UDP-3-O-acyl-N-acetylglucosamine deacetylase (lpxC)
  3. UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase (lpxD), UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase (lpxD)
  4. UDP-2,3-diacylglucosamine hydrolase (lpxH)
  5. Lipid-A-disaccharide synthase (lpxB), Lipid-A-disaccharide synthase (lpxB)
  6. Tetraacyldisaccharide 4'-kinase (lpxK), Tetraacyldisaccharide 4'-kinase (lpxK)
This subpathway is part of the pathway lipid IV(A) biosynthesis, which is itself part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine, the pathway lipid IV(A) biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00477

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferaseUniRule annotation (EC:2.3.1.129UniRule annotation)
Short name:
UDP-N-acetylglucosamine acyltransferaseUniRule annotation
Gene namesi
Name:lpxAUniRule annotation
Ordered Locus Names:YPO1056, y3123, YP_2794
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001880811 – 262Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferaseAdd BLAST262

Proteomic databases

PaxDbiQ8ZH56

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi187410.y3123

Structurei

3D structure databases

ProteinModelPortaliQ8ZH56
SMRiQ8ZH56
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family. LpxA subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105DAF Bacteria
COG1043 LUCA
HOGENOMiHOG000294326
KOiK00677
OMAiRECVTIN

Family and domain databases

CDDicd03351 LbH_UDP-GlcNAc_AT, 1 hit
Gene3Di1.20.1180.10, 1 hit
HAMAPiMF_00387 LpxA, 1 hit
InterProiView protein in InterPro
IPR029098 Acetyltransf_C
IPR037157 Acetyltransf_C_sf
IPR001451 Hexapep
IPR018357 Hexapep_transf_CS
IPR010137 Lipid_A_LpxA
IPR011004 Trimer_LpxA-like_sf
PANTHERiPTHR43480 PTHR43480, 1 hit
PfamiView protein in Pfam
PF13720 Acetyltransf_11, 1 hit
PF00132 Hexapep, 2 hits
PIRSFiPIRSF000456 UDP-GlcNAc_acltr, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
TIGRFAMsiTIGR01852 lipid_A_lpxA, 1 hit
PROSITEiView protein in PROSITE
PS00101 HEXAPEP_TRANSFERASES, 2 hits

Sequencei

Sequence statusi: Complete.

Q8ZH56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDKTAFIHP SSIVEEGAII GAGVYIGPFC IVGSQVEIGA GTELKSHVVV
60 70 80 90 100
NGITKIGCDN QIYQFASIGE ANQDLKYAGE PTRVEVGDRN RIRESVTIHR
110 120 130 140 150
GTTQGGGVTK VGCDNLLMVN THVAHDCVIG NRCILANNAA LGGHVEIDDY
160 170 180 190 200
AIIGGMTAIH QFCVIGAHVM VGGCSGITQD VPPFVIAQGN HATPFGINIE
210 220 230 240 250
GLKRRGFDKE SLHAIRSAYK LLYRSGRTLD EVKPEIAELA EQYPVVKAFN
260
DFFARSTRGI IR
Length:262
Mass (Da):28,117
Last modified:March 1, 2002 - v1
Checksum:iC749FF7F53216DF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL19721.1
AE009952 Genomic DNA Translation: AAM86673.1
AE017042 Genomic DNA Translation: AAS62978.1
PIRiAG0129
RefSeqiWP_002212143.1, NZ_PDBR01000044.1
YP_002346099.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM86673; AAM86673; y3123
AAS62978; AAS62978; YP_2794
GeneIDi1173896
KEGGiype:YPO1056
ypk:y3123
ypm:YP_2794
PATRICifig|214092.21.peg.1344

Similar proteinsi

Entry informationi

Entry nameiLPXA_YERPE
AccessioniPrimary (citable) accession number: Q8ZH56
Secondary accession number(s): Q0WHY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health