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Q8ZH55

- LPXB_YERPE

UniProt

Q8ZH55 - LPXB_YERPE

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, YPO1057, y3122, YP_2793
Organism
Yersinia pestis
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciYPES214092:GKDD-1044-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:YPO1057, y3122, YP_2793
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Lipid-A-disaccharide synthaseUniRule annotation
PRO_0000190197Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi214092.YPO1057.

Structurei

3D structure databases

ProteinModelPortaliQ8ZH55.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZH55-1 [UniParc]FASTAAdd to Basket

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MQNSPLTADC SLNAGRPLTI GLVAGETSGD ILGAGLIRAL KVQVPNARFV    50
GVAGPLMQAE GCEAWYEMEE LAVMGVVEVL ERLPRLLKIR KDLTQRFSEL 100
SPDVFVGIDA PDFNITLEGR LKQRGIRTIH YVSPSVWAWR QKRVFKIGKA 150
TDMVLAFLPF EKAFYDRFNV PCRFIGHTMA DAMPLVPDQQ AARAELGIAP 200
NATCLALLPG SRHSEVEMLS ADFLRTAVIL RDKLPNLEVV VPLVNSKRRE 250
QFERIKAEIA PDLSVHLLDG KARVAMIASD AALLASGTAA LECMLAKCPM 300
VVGYRMKPFT FWLAERLVKT PYVSLPNLLA GEELVTELLQ QECQPQKLAG 350
ALLPLLQGGS EIAALKERFL VLHQSIRCGA DEQAAQAVLE LADR 394
Length:394
Mass (Da):43,261
Last modified:March 1, 2002 - v1
Checksum:iF4A481D7C188B25C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL19722.1.
AE009952 Genomic DNA. Translation: AAM86672.1.
AE017042 Genomic DNA. Translation: AAS62977.1.
PIRiAH0129.
RefSeqiNP_670421.1. NC_004088.1.
NP_994100.1. NC_005810.1.
YP_002346100.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM86672; AAM86672; y3122.
AAS62977; AAS62977; YP_2793.
GeneIDi1148069.
1173897.
2765716.
KEGGiype:YPO1057.
ypk:y3122.
ypm:YP_2793.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL19722.1 .
AE009952 Genomic DNA. Translation: AAM86672.1 .
AE017042 Genomic DNA. Translation: AAS62977.1 .
PIRi AH0129.
RefSeqi NP_670421.1. NC_004088.1.
NP_994100.1. NC_005810.1.
YP_002346100.1. NC_003143.1.

3D structure databases

ProteinModelPortali Q8ZH55.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 214092.YPO1057.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

DNASUi 1148069.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM86672 ; AAM86672 ; y3122 .
AAS62977 ; AAS62977 ; YP_2793 .
GeneIDi 1148069.
1173897.
2765716.
KEGGi ype:YPO1057.
ypk:y3122.
ypm:YP_2793.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci YPES214092:GKDD-1044-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiLPXB_YERPE
AccessioniPrimary (citable) accession number: Q8ZH55
Secondary accession number(s): Q0WHY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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