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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + 2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate = UDP + 2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-beta-D-glucosaminyl-(1->6)-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi: lipid IV(A) biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA), Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA)
  2. UDP-3-O-acyl-N-acetylglucosamine deacetylase (lpxC), UDP-3-O-acyl-N-acetylglucosamine deacetylase (lpxC)
  3. UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase (lpxD), UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase (lpxD)
  4. UDP-2,3-diacylglucosamine hydrolase (lpxH)
  5. Lipid-A-disaccharide synthase (lpxB), Lipid-A-disaccharide synthase (lpxB)
  6. Tetraacyldisaccharide 4'-kinase (lpxK), Tetraacyldisaccharide 4'-kinase (lpxK)
This subpathway is part of the pathway lipid IV(A) biosynthesis, which is itself part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine, the pathway lipid IV(A) biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processLipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481

Protein family/group databases

CAZyiGT19 Glycosyltransferase Family 19

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:YPO1057, y3122, YP_2793
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001901971 – 394Lipid-A-disaccharide synthaseAdd BLAST394

Proteomic databases

PaxDbiQ8ZH55

Interactioni

Protein-protein interaction databases

STRINGi187410.y3122

Structurei

3D structure databases

ProteinModelPortaliQ8ZH55
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D0V Bacteria
COG0763 LUCA
HOGENOMiHOG000018003
KOiK00748
OMAiPTVWAWR

Family and domain databases

HAMAPiMF_00392 LpxB, 1 hit
InterProiView protein in InterPro
IPR003835 Glyco_trans_19
PANTHERiPTHR30372 PTHR30372, 1 hit
PfamiView protein in Pfam
PF02684 LpxB, 1 hit
TIGRFAMsiTIGR00215 lpxB, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZH55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNSPLTADC SLNAGRPLTI GLVAGETSGD ILGAGLIRAL KVQVPNARFV
60 70 80 90 100
GVAGPLMQAE GCEAWYEMEE LAVMGVVEVL ERLPRLLKIR KDLTQRFSEL
110 120 130 140 150
SPDVFVGIDA PDFNITLEGR LKQRGIRTIH YVSPSVWAWR QKRVFKIGKA
160 170 180 190 200
TDMVLAFLPF EKAFYDRFNV PCRFIGHTMA DAMPLVPDQQ AARAELGIAP
210 220 230 240 250
NATCLALLPG SRHSEVEMLS ADFLRTAVIL RDKLPNLEVV VPLVNSKRRE
260 270 280 290 300
QFERIKAEIA PDLSVHLLDG KARVAMIASD AALLASGTAA LECMLAKCPM
310 320 330 340 350
VVGYRMKPFT FWLAERLVKT PYVSLPNLLA GEELVTELLQ QECQPQKLAG
360 370 380 390
ALLPLLQGGS EIAALKERFL VLHQSIRCGA DEQAAQAVLE LADR
Length:394
Mass (Da):43,261
Last modified:March 1, 2002 - v1
Checksum:iF4A481D7C188B25C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL19722.1
AE009952 Genomic DNA Translation: AAM86672.1
AE017042 Genomic DNA Translation: AAS62977.1
PIRiAH0129
RefSeqiWP_002212144.1, NZ_PDBR01000044.1
YP_002346100.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM86672; AAM86672; y3122
AAS62977; AAS62977; YP_2793
GeneIDi1173897
KEGGiype:YPO1057
ypj:CH55_3807
ypk:y3122
ypl:CH46_4087
ypm:YP_2793
ypv:BZ15_2513
ypw:CH59_802
PATRICifig|214092.21.peg.1345

Similar proteinsi

Entry informationi

Entry nameiLPXB_YERPE
AccessioniPrimary (citable) accession number: Q8ZH55
Secondary accession number(s): Q0WHY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health