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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciYPES214092:GKDD-1044-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:YPO1057, y3122, YP_2793
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815 Componenti: Chromosome UP000001019 Componenti: Chromosome UP000002490 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Lipid-A-disaccharide synthasePRO_0000190197Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi214092.YPO1057.

Structurei

3D structure databases

ProteinModelPortaliQ8ZH55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiQPWVGLP.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZH55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNSPLTADC SLNAGRPLTI GLVAGETSGD ILGAGLIRAL KVQVPNARFV
60 70 80 90 100
GVAGPLMQAE GCEAWYEMEE LAVMGVVEVL ERLPRLLKIR KDLTQRFSEL
110 120 130 140 150
SPDVFVGIDA PDFNITLEGR LKQRGIRTIH YVSPSVWAWR QKRVFKIGKA
160 170 180 190 200
TDMVLAFLPF EKAFYDRFNV PCRFIGHTMA DAMPLVPDQQ AARAELGIAP
210 220 230 240 250
NATCLALLPG SRHSEVEMLS ADFLRTAVIL RDKLPNLEVV VPLVNSKRRE
260 270 280 290 300
QFERIKAEIA PDLSVHLLDG KARVAMIASD AALLASGTAA LECMLAKCPM
310 320 330 340 350
VVGYRMKPFT FWLAERLVKT PYVSLPNLLA GEELVTELLQ QECQPQKLAG
360 370 380 390
ALLPLLQGGS EIAALKERFL VLHQSIRCGA DEQAAQAVLE LADR
Length:394
Mass (Da):43,261
Last modified:March 1, 2002 - v1
Checksum:iF4A481D7C188B25C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL19722.1.
AE009952 Genomic DNA. Translation: AAM86672.1.
AE017042 Genomic DNA. Translation: AAS62977.1.
PIRiAH0129.
RefSeqiNP_670421.1. NC_004088.1.
NP_994100.1. NC_005810.1.
YP_002346100.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM86672; AAM86672; y3122.
AAS62977; AAS62977; YP_2793.
GeneIDi1173897.
KEGGiype:YPO1057.
ypk:y3122.
ypm:YP_2793.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL19722.1.
AE009952 Genomic DNA. Translation: AAM86672.1.
AE017042 Genomic DNA. Translation: AAS62977.1.
PIRiAH0129.
RefSeqiNP_670421.1. NC_004088.1.
NP_994100.1. NC_005810.1.
YP_002346100.1. NC_003143.1.

3D structure databases

ProteinModelPortaliQ8ZH55.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi214092.YPO1057.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Protocols and materials databases

DNASUi1148069.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM86672; AAM86672; y3122.
AAS62977; AAS62977; YP_2793.
GeneIDi1173897.
KEGGiype:YPO1057.
ypk:y3122.
ypm:YP_2793.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiQPWVGLP.
OrthoDBiEOG6FBWZR.

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.
BioCyciYPES214092:GKDD-1044-MONOMER.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiLPXB_YERPE
AccessioniPrimary (citable) accession number: Q8ZH55
Secondary accession number(s): Q0WHY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2002
Last modified: April 1, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.