Q8ZH36 (DKGB_YERPE) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 72.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: 2,5-diketo-D-gluconic acid reductase B Short name=2,5-DKG reductase B Short name=2,5-DKGR B Short name=25DKGR-B EC=1.1.1.274 Alternative name(s): AKR5D | ||||||
| Gene names |
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| Organism | Yersinia pestis | ||||||
| Taxonomic identifier | 632 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia |
Protein attributes
| Sequence length | 267 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG) By similarity. |
| Catalytic activity | 2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH. |
| Subunit structure | Monomer By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Miscellaneous | 2-keto-L-gulonic acid is a key intermediate in the production of L-ascorbic acid (vitamin C). |
| Sequence similarities | Belongs to the aldo/keto reductase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ascorbate biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | L-ascorbic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | 2,5-didehydrogluconate reductase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL590842 Genomic DNA. Translation: CAL19741.1. AE009952 Genomic DNA. Translation: AAM86651.1. AE017042 Genomic DNA. Translation: AAS62958.1. |
| PIR | AC0132. |
| RefSeq | NP_670400.1. NC_004088.1. NP_994081.1. NC_005810.1. YP_002346119.1. NC_003143.1. |
3D structure databases | |
| ProteinModelPortal | Q8ZH36. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1148048. 1173921. 2764883. |
| GenomeReviews | Gene locus y3101 in contig AE009952_GR. Gene locus YP_2774 in contig AE017042_GR. Gene locus YPO1075 in contig AL590842_GR. |
| KEGG | ype:YPO1075. ypk:y3101. ypm:YP_2774. |
Phylogenomic databases | |
| HOGENOM | HBG605727. |
| OMA | LAWAMQL. |
| ProtClustDB | PRK11172. |
Enzyme and pathway databases | |
| BioCyc | YPES187410:Y3101-MONOMER. YPES214092:YPO1075-MONOMER. |
Family and domain databases | |
| InterPro | IPR001395. Aldo/ket_red. IPR018170. Aldo/ket_reductase_CS. IPR020471. Aldo/keto_reductase_subgr. IPR023210. NADP_OxRdtase_dom. [Graphical view] |
| Gene3D | G3DSA:3.20.20.100. Aldo/ket_red. 1 hit. |
| KO | K06222. |
| PANTHER | PTHR11732. Aldo/ket_red. 1 hit. |
| Pfam | PF00248. Aldo_ket_red. 1 hit. [Graphical view] |
| PIRSF | PIRSF000097. AKR. 1 hit. |
| PRINTS | PR00069. ALDKETRDTASE. |
| SUPFAM | SSF51430. Aldo/ket_red. 1 hit. |
| PROSITE | PS00798. ALDOKETO_REDUCTASE_1. 1 hit. PS00062. ALDOKETO_REDUCTASE_2. 1 hit. PS00063. ALDOKETO_REDUCTASE_3. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DKGB_YERPE | ||||||||
| Accession | Primary (citable) accession number: Q8ZH36 Secondary accession number(s): Q0WHW9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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