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Q8ZGX4

- 6PGL_YERPE

UniProt

Q8ZGX4 - 6PGL_YERPE

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Protein
6-phosphogluconolactonase
Gene
pgl, YPO1149, y3033, YP_1011
Organism
Yersinia pestis
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate By similarity.UniRule annotation

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 6-phosphogluconolactonase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

BioCyciYPES214092:GKDD-1144-MONOMER.
UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6-P-gluconolactonase
Gene namesi
Name:pgl
Ordered Locus Names:YPO1149, y3033, YP_1011
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3343346-phosphogluconolactonaseUniRule annotation
PRO_0000171142Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiQ8ZGX4. 7 interactions.
STRINGi214092.YPO1149.

Structurei

3D structure databases

ProteinModelPortaliQ8ZGX4.
SMRiQ8ZGX4. Positions 1-329.

Family & Domainsi

Sequence similaritiesi

Belongs to the cycloisomerase 2 family.

Phylogenomic databases

eggNOGiCOG2706.
HOGENOMiHOG000257418.
KOiK07404.
OMAiPMVIAPN.
OrthoDBiEOG615VK7.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_01605. 6P_gluconolactonase.
InterProiIPR022528. 6-phosphogluconolactonase_YbhE.
IPR019405. Lactonase_7-beta_prop.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF10282. Lactonase. 1 hit.
[Graphical view]
SUPFAMiSSF50974. SSF50974. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZGX4-1 [UniParc]FASTAAdd to Basket

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MKQAVYVASP DSQQIHVWQL DSAGELTLLQ TVDVPGQVQP MAISPNQRHL    50
YVGVRPDFGI VSYHIADDGT LTAAGMAPLP GSPTHIDTDR QGRFLFSASY 100
SFNCVSISPI DTHGVVQAPI QQLDDLPAPH SANIDPTNQI LLVPCLKEDK 150
VRLFDLSAEG QLTPHAQADI TVAAGAGPRH MAFHPNHQVA YCVNELNSSV 200
DVYQISNNGQ EYHLVQSLDA MPADFTGTRW AADIHITPNG RYLYISDRTA 250
NLLGIFTVSE DGRVISLVGH HLTEAQPRGF NIDHSGNFLI ASGQKSDHIE 300
VYRIDQNTGE LTTLKRYPVG KGPMWVSIRG AQNS 334
Length:334
Mass (Da):36,446
Last modified:March 1, 2002 - v1
Checksum:i4BDAC511EF8E0F06
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL19813.1.
AE009952 Genomic DNA. Translation: AAM86584.1.
AE017042 Genomic DNA. Translation: AAS61262.1.
PIRiAC0141.
RefSeqiNP_670333.1. NC_004088.1.
NP_992385.1. NC_005810.1.
YP_002346188.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM86584; AAM86584; y3033.
AAS61262; AAS61262; YP_1011.
GeneIDi1147980.
1173998.
2764787.
KEGGiype:YPO1149.
ypk:y3033.
ypm:YP_1011.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL19813.1 .
AE009952 Genomic DNA. Translation: AAM86584.1 .
AE017042 Genomic DNA. Translation: AAS61262.1 .
PIRi AC0141.
RefSeqi NP_670333.1. NC_004088.1.
NP_992385.1. NC_005810.1.
YP_002346188.1. NC_003143.1.

3D structure databases

ProteinModelPortali Q8ZGX4.
SMRi Q8ZGX4. Positions 1-329.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8ZGX4. 7 interactions.
STRINGi 214092.YPO1149.

Protocols and materials databases

DNASUi 1147980.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM86584 ; AAM86584 ; y3033 .
AAS61262 ; AAS61262 ; YP_1011 .
GeneIDi 1147980.
1173998.
2764787.
KEGGi ype:YPO1149.
ypk:y3033.
ypm:YP_1011.

Phylogenomic databases

eggNOGi COG2706.
HOGENOMi HOG000257418.
KOi K07404.
OMAi PMVIAPN.
OrthoDBi EOG615VK7.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00409 .
BioCyci YPES214092:GKDD-1144-MONOMER.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
HAMAPi MF_01605. 6P_gluconolactonase.
InterProi IPR022528. 6-phosphogluconolactonase_YbhE.
IPR019405. Lactonase_7-beta_prop.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
Pfami PF10282. Lactonase. 1 hit.
[Graphical view ]
SUPFAMi SSF50974. SSF50974. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry namei6PGL_YERPE
AccessioniPrimary (citable) accession number: Q8ZGX4
Secondary accession number(s): Q0WHQ0, Q74W78, Q7CH64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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