Q8ZGV9 (BETB_YERPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8

Gene names

Name:	betB
Ordered Locus Names:	YPO1166, YP_0993

Organism

Yersinia pestis

Taxonomic identifier

632 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	betaine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Betaine aldehyde dehydrogenase HAMAP MF_00804		PRO_0000056561
Regions
	Nucleotide binding	229 – 234	6	NAD By similarity
Sites
	Active site	252	1	By similarity
	Active site	286	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8ZGV9 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: F44CCA7CEE56F0B9	FASTA	490	52,596
	10 20 30 40 50 60 MSRYGLQKLY INGAYTDSTS GDTFDAVNPA NGECIAQLQA ANAQDVDKAV AAAKQGQPVW 70 80 90 100 110 120 AAMTAMERSR ILRRAVDILR DRNDELAAIE TADTGKPLSE TRSVDIVTGA DVLEYYAGLI 130 140 150 160 170 180 PALEGQQIPL RGSAFVYTRR EPLGVVAGIG AWNYPLQIAL WKSAPALAAG NAMIFKPSEV 190 200 210 220 230 240 TSLTALKLAG IYTEAGLPAG VFNVLTGSGD QVGQMLTEHP GIAKVSFTGG IASGKKVMAN 250 260 270 280 290 300 AAGSTLKDVT MELGGKSPLI IFADADLDKA ADIAMMANFY SSGQVCTNGT RVFVPQALQA 310 320 330 340 350 360 AFEQKIVERV KRIHIGDPSD ERTNFGPLVS FQHRDSVMRY IDSGKREGAT LLIGGYSLTE 370 380 390 400 410 420 GALAHGAYVA PTVFTHCRDD MQIVREEIFG PVMSILSYQS EEEVIRRAND TEYGLAAGVV 430 440 450 460 470 480 TQDLNRAHRV IHQLQAGICW INTWGESAPE MPVGGYKHSG VGRENGISTL EHYTQIKSIQ 490 VELGSFNSVF

References

[1]	"Genome sequence of Yersinia pestis, the causative agent of plague." Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:523-527(2001) [PubMed: 11586360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CO-92 / Biovar Orientalis.
[2]	"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans." Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R. DNA Res. 11:179-197(2004) [PubMed: 15368893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 91001 / Biovar Mediaevalis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL590842 Genomic DNA. Translation: CAL19830.1. AE017042 Genomic DNA. Translation: AAS61244.1.
PIR	AD0143.
RefSeq	NP_992367.1. NC_005810.1. YP_002346205.1. NC_003143.1.
3D structure databases
ProteinModelPortal	Q8ZGV9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1174015. 2764902.
GenomeReviews	Gene locus YP_0993 in contig AE017042_GR. Gene locus YPO1166 in contig AL590842_GR.
KEGG	ype:YPO1166. ypm:YP_0993.
PATRIC	18591633. VBIYerPes7843_1541.
Phylogenomic databases
HOGENOM	HBG752218.
OMA	GRENGLM.
ProtClustDB	PRK13252.
Enzyme and pathway databases
BioCyc	YPES214092:YPO1166-MONOMER.
Family and domain databases
HAMAP	MF_00804. BADH. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR011264. Betaine_Ald_DH. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KO	K00130.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR01804. BADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_YERPE

Accession

Primary (citable) accession number: Q8ZGV9
Secondary accession number(s): Q0WHN3, Q74W89

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program