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Protein

Ubiquinone biosynthesis O-methyltransferase

Gene

ubiG

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n.UniRule annotation
S-adenosyl-L-methionine + 3-(all-trans-polyprenyl)benzene-1,2-diol = S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44S-adenosyl-L-methionineUniRule annotation1
Binding sitei64S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei85S-adenosyl-L-methionineUniRule annotation1
Binding sitei129S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processUbiquinone biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone biosynthesis O-methyltransferaseUniRule annotation
Alternative name(s):
2-polyprenyl-6-hydroxyphenol methylaseUniRule annotation (EC:2.1.1.222UniRule annotation)
3-demethylubiquinone 3-O-methyltransferaseUniRule annotation (EC:2.1.1.64UniRule annotation)
Gene namesi
Name:ubiGUniRule annotation
Ordered Locus Names:YPO1215, y2973, YP_0922
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001934131 – 242Ubiquinone biosynthesis O-methyltransferaseAdd BLAST242

Proteomic databases

PaxDbiQ8ZGR6

Interactioni

Protein-protein interaction databases

IntActiQ8ZGR6, 5 interactors
STRINGi187410.y2973

Structurei

3D structure databases

ProteinModelPortaliQ8ZGR6
SMRiQ8ZGR6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. UbiG/COQ3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108HWB Bacteria
COG2227 LUCA
HOGENOMiHOG000278065
KOiK00568
OMAiGTHDWEK

Family and domain databases

HAMAPiMF_00472 UbiG, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR010233 UbiG_MeTrfase
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR01983 UbiG, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZGR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAKTTSRHH NVDEQEIAKF EAVASRWWDL EGEFKPLHRI NPLRLNYILQ
60 70 80 90 100
RSGGIFEKKV LDVGCGGGIL AESMAREGAQ VTGLDMGYEP LQVARLHALE
110 120 130 140 150
TGVKLEYVQE TVENHAQQHP QHYDVVTCME MLEHVPDPAS VVRACAQLVK
160 170 180 190 200
PGGHVFFSTI NRNTKSWLMA VVGAEYLLKM VPKGTHDAKK FIRPSELIGW
210 220 230 240
VDQTPLLERH IIGLHYNPIT DHFKLGRNVD VNYMVHTQRD SE
Length:242
Mass (Da):27,466
Last modified:March 1, 2002 - v1
Checksum:iA397DB4825EEDA34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL19876.1
AE009952 Genomic DNA Translation: AAM86524.1
AE017042 Genomic DNA Translation: AAS61177.1
PIRiAB0149
RefSeqiWP_002210820.1, NZ_PDBR01000022.1
YP_002346249.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM86524; AAM86524; y2973
AAS61177; AAS61177; YP_0922
GeneIDi1174061
KEGGiype:YPO1215
ypj:CH55_1334
ypk:y2973
ypl:CH46_3917
ypm:YP_0922
ypv:BZ15_2342
ypw:CH59_629
PATRICifig|214092.21.peg.1517

Similar proteinsi

Entry informationi

Entry nameiUBIG_YERPE
AccessioniPrimary (citable) accession number: Q8ZGR6
Secondary accession number(s): Q0WHI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health