Reviewed, UniProtKB/Swiss-Prot Q8ZGJ9 (RPIA2_YERPE)

Names and origin

Protein names

Recommended name:
    Ribose-5-phosphate isomerase A 2
    EC=5.3.1.6
Alternative name(s):
    Phosphoriboisomerase A 2
      Short name=PRI 2

Gene names

Name:	rpiA2
Ordered Locus Names:	YPO1292, y2892, YP_1299

Organism

Yersinia pestis [Complete proteome] [HAMAP]

Taxonomic identifier

632 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	236 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-ribose 5-phosphate = D-ribulose 5-phosphate. HAMAP MF_00170
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1. HAMAP MF_00170
Sequence similarities	Belongs to the ribose 5-phosphate isomerase family.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt, non-oxidative branch Inferred from electronic annotation. Source: HAMAP
Molecular function	ribose-5-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 236	236	Ribose-5-phosphate isomerase A 2 HAMAP MF_00170		PRO_0000158502

Sequences

	Sequence		Length	Mass (Da)
	Q8ZGJ9-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 2E1D870A15A044FA	FASTA	236	26,034
	10 20 30 40 50 60 MSNQQNDAKR AAARRVIQDF VFDGMTLGLG SGTTSHFFVR ELGQHVAKGL QLTCTTTSRA 70 80 90 100 110 120 TSEVARDVGI ELSDPNEMNE IDLTIDGPDE IDRRFNMIKG GGACLLWEKI IAHASKRMIC 130 140 150 160 170 180 ICDETKIVNC LGQFPLPVEI VPFAWKQTER RVERVLAEQG LHHVPIIRRM GGGHPVITDS 190 200 210 220 230 GNFILDCHCG AIITAPEPLE IELNRIPGVV ENGLFTREAT GMVVGYFDGS SYVQLR

References

[1]	"Genome sequence of Yersinia pestis, the causative agent of plague." Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:523-527(2001) [PubMed: 11586360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CO-92 / Biovar Orientalis.
[2]	"Genome sequence of Yersinia pestis KIM." Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. , Matson J.S., Blattner F.R., Perry R.D. J. Bacteriol. 184:4601-4611(2002) [PubMed: 12142430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KIM5 / Biovar Mediaevalis.
[3]	"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans." Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R. DNA Res. 11:179-197(2004) [PubMed: 15368893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL590842 Genomic DNA. Translation: CAL19946.1. AE009952 Genomic DNA. Translation: AAM86443.1. Different initiation. AE017042 Genomic DNA. Translation: AAS61542.1. Different initiation.
PIR	AH0157.
RefSeq	NP_670192.1. NP_992665.1. YP_002346318.1.
3D structure databases
SMR	Q8ZGJ9. Positions 5-231.
ModBase	Search...
Genome annotation databases
GeneID	1147839. 1174135. 2763250.
GenomeReviews	Gene locus y2892 in contig AE009952_GR. Gene locus YP_1299 in contig AE017042_GR. Gene locus YPO1292 in contig AL590842_GR.
KEGG	ype:YPO1292. ypk:y2892. ypm:YP_1299.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG515603.
OMA	VENGLFI.
Enzyme and pathway databases
BioCyc	YPES187410:Y2892-MONOMER. YPES214092:YPO1292-MONOMER. YPES229193:YP1299-MONOMER.
BRENDA	5.3.1.6. 142588.
Family and domain databases
HAMAP	MF_00170. Rib_5P_isom_A. [Tree]
InterPro	IPR004788. Ribose5P_isomerase_typA. IPR020672. Ribose5P_isomerase_typA_subgr. [Graphical view]
PANTHER	PTHR11934. RpiA. 1 hit.
Pfam	PF06026. Rib_5-P_isom_A. 1 hit. [Graphical view]
TIGRFAMs	TIGR00021. rpiA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RPIA2_YERPE

Accession

Primary (citable) accession number: Q8ZGJ9
Secondary accession number(s): Q0WHC0, Q8D025

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	March 1, 2002
Last modified:	February 9, 2010
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)