Reviewed, UniProtKB/Swiss-Prot Q8ZGH4 (DEOC1_YERPE)

Names and origin

Protein names

Recommended name:
    Deoxyribose-phosphate aldolase 1
    EC=4.1.2.4
Alternative name(s):
    Phosphodeoxyriboaldolase 1
      Short name=Deoxyriboaldolase 1
      Short name=DERA 1

Gene names

Name:	deoC1
Synonyms:	dra
Ordered Locus Names:	YPO1323, y2860, YP_1269

Organism

Yersinia pestis [Complete proteome] [HAMAP]

Taxonomic identifier

632 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114
Subcellular location	Cytoplasm By similarity HAMAP MF_00114.
Sequence similarities	Belongs to the deoC/fbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate catabolic process Inferred from electronic annotation. Source: HAMAP deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 223	223	Deoxyribose-phosphate aldolase 1 HAMAP MF_00114		PRO_0000057285
Sites
	Active site	153	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	182	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8ZGH4-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 1F9EB9959D648AED	FASTA	223	23,266
	10 20 30 40 50 60 MTTNYAHYID HTLLAMDATE AQIIKLCEEA KQHHFYAVCV NSGYVPVAAQ QLAGSSVKVC 70 80 90 100 110 120 SVIGFPLGAG LTAAKAFEAQ AAINAGAQEI DMVINVGWLK SGKIADVKAD IKAVRDNCAA 130 140 150 160 170 180 TPLKVILETC LLSDEQIVQV CEMCRELDVA FVKTSTGFST GGAKEEHVKL MRATVGPVMG 190 200 210 220 VKASGAVRDR ATAETMIQAG ATRIGTSSGV AIVSGQQAAA SGY

References

[1]	"Genome sequence of Yersinia pestis, the causative agent of plague." Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:523-527(2001) [PubMed: 11586360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CO-92 / Biovar Orientalis.
[2]	"Genome sequence of Yersinia pestis KIM." Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. , Matson J.S., Blattner F.R., Perry R.D. J. Bacteriol. 184:4601-4611(2002) [PubMed: 12142430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KIM5 / Biovar Mediaevalis.
[3]	"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans." Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R. DNA Res. 11:179-197(2004) [PubMed: 15368893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL590842 Genomic DNA. Translation: CAL19976.1. AE009952 Genomic DNA. Translation: AAM86411.1. AE017042 Genomic DNA. Translation: AAS61512.1.
PIR	AF0161.
RefSeq	NP_670160.1. NP_992635.1. YP_002346348.1.
3D structure databases
SMR	Q8ZGH4. Positions 4-219.
ModBase	Search...
Genome annotation databases
GeneID	1147807. 1174165. 2764428.
GenomeReviews	Gene locus y2860 in contig AE009952_GR. Gene locus YP_1269 in contig AE017042_GR. Gene locus YPO1323 in contig AL590842_GR.
KEGG	ype:YPO1323. ypk:y2860. ypm:YP_1269.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG636421.
OMA	AKMIDHT.
Enzyme and pathway databases
BioCyc	YPES187410:Y2860-MONOMER. YPES214092:YPO1323-MONOMER. YPES229193:YP1269-MONOMER.
BRENDA	4.1.2.4. 142588.
Family and domain databases
HAMAP	MF_00114. DeoC_type1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. deoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC1_YERPE

Accession

Primary (citable) accession number: Q8ZGH4
Secondary accession number(s): Q0WH90

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	March 1, 2002
Last modified:	February 9, 2010
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)