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Q8ZGD2

- LFTR_YERPE

UniProt

Q8ZGD2 - LFTR_YERPE

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Protein

Leucyl/phenylalanyl-tRNA--protein transferase

Gene

aat

Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.UniRule annotation

Catalytic activityi

L-leucyl-tRNA(Leu) + [protein] = tRNA(Leu) + L-leucyl-[protein].UniRule annotation
L-phenylalanyl-tRNA(Phe) + [protein] = tRNA + L-phenylalanyl-[protein].UniRule annotation

GO - Molecular functioni

  1. leucyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciYPES214092:GKDD-1358-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucyl/phenylalanyl-tRNA--protein transferaseUniRule annotation (EC:2.3.2.6UniRule annotation)
Alternative name(s):
L/F-transferaseUniRule annotation
LeucyltransferaseUniRule annotation
PhenyalanyltransferaseUniRule annotation
Gene namesi
Name:aatUniRule annotation
Ordered Locus Names:YPO1371, y2806, YP_1222
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236Leucyl/phenylalanyl-tRNA--protein transferasePRO_0000207254Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi214092.YPO1371.

Structurei

3D structure databases

ProteinModelPortaliQ8ZGD2.
SMRiQ8ZGD2. Positions 1-229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L/F-transferase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2360.
HOGENOMiHOG000102325.
KOiK00684.
OMAiWSPDPRG.
OrthoDBiEOG6WX4R3.

Family and domain databases

HAMAPiMF_00688. Leu_Phe_trans.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR004616. Leu/Phe-tRNA_Trfase.
[Graphical view]
PfamiPF03588. Leu_Phe_trans. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR00667. aat. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZGD2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVTQLSSQS FIFPSPELAL REPNGLLALG GDLTAPRLLA AYQRGIFPWF
60 70 80 90 100
NPGEMILWWS PDPRAVLFPE DLHISRSMRR FIRHCPYRFT LNHAFADVIS
110 120 130 140 150
ACATERDEGT WIGRDVQQAY CQLHALGHAH SLEVWLENEL VGGLYGVAVG
160 170 180 190 200
AVFCGESMFS RADNASKSAL MVFCHHFTQH GGELIDCQVL NAHTASLGAV
210 220 230
EIPRNFFLQQ LSQLQFSPLP AECWLPQSLN FSSAMQ
Length:236
Mass (Da):26,403
Last modified:March 1, 2002 - v1
Checksum:i19B93E1B026F2547
GO

Sequence cautioni

The sequence AAM86357.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAS61465.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL20023.1.
AE009952 Genomic DNA. Translation: AAM86357.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS61465.1. Different initiation.
PIRiAE0167.
RefSeqiNP_670106.1. NC_004088.1.
NP_992588.1. NC_005810.1.
YP_002346394.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM86357; AAM86357; y2806.
AAS61465; AAS61465; YP_1222.
GeneIDi1147753.
1174212.
2765528.
KEGGiype:YPO1371.
ypk:y2806.
ypm:YP_1222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL20023.1 .
AE009952 Genomic DNA. Translation: AAM86357.1 . Different initiation.
AE017042 Genomic DNA. Translation: AAS61465.1 . Different initiation.
PIRi AE0167.
RefSeqi NP_670106.1. NC_004088.1.
NP_992588.1. NC_005810.1.
YP_002346394.1. NC_003143.1.

3D structure databases

ProteinModelPortali Q8ZGD2.
SMRi Q8ZGD2. Positions 1-229.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 214092.YPO1371.

Protocols and materials databases

DNASUi 1147753.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM86357 ; AAM86357 ; y2806 .
AAS61465 ; AAS61465 ; YP_1222 .
GeneIDi 1147753.
1174212.
2765528.
KEGGi ype:YPO1371.
ypk:y2806.
ypm:YP_1222.

Phylogenomic databases

eggNOGi COG2360.
HOGENOMi HOG000102325.
KOi K00684.
OMAi WSPDPRG.
OrthoDBi EOG6WX4R3.

Enzyme and pathway databases

BioCyci YPES214092:GKDD-1358-MONOMER.

Family and domain databases

HAMAPi MF_00688. Leu_Phe_trans.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR004616. Leu/Phe-tRNA_Trfase.
[Graphical view ]
Pfami PF03588. Leu_Phe_trans. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
TIGRFAMsi TIGR00667. aat. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiLFTR_YERPE
AccessioniPrimary (citable) accession number: Q8ZGD2
Secondary accession number(s): Q0WH44, Q8D042
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3