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Protein

Leucyl/phenylalanyl-tRNA--protein transferase

Gene

aat

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.UniRule annotation

Catalytic activityi

L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = tRNA(Leu) + N-terminal L-leucyl-L-lysyl-[protein].UniRule annotation
L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = tRNA(Leu) + N-terminal L-leucyl-L-arginyl-[protein].UniRule annotation
L-phenylalanyl-tRNA(Phe) + [protein] = tRNA + L-phenylalanyl-[protein].UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Leucyl/phenylalanyl-tRNA--protein transferaseUniRule annotation (EC:2.3.2.6UniRule annotation)
Alternative name(s):
L/F-transferaseUniRule annotation
LeucyltransferaseUniRule annotation
PhenyalanyltransferaseUniRule annotation
Gene namesi
Name:aatUniRule annotation
Ordered Locus Names:YPO1371, y2806, YP_1222
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002072541 – 236Leucyl/phenylalanyl-tRNA--protein transferaseAdd BLAST236

Proteomic databases

PaxDbiQ8ZGD2

Interactioni

Protein-protein interaction databases

STRINGi187410.y2806

Structurei

3D structure databases

ProteinModelPortaliQ8ZGD2
SMRiQ8ZGD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L/F-transferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108R4Z Bacteria
COG2360 LUCA
HOGENOMiHOG000102325
KOiK00684
OMAiYRQGIFP

Family and domain databases

HAMAPiMF_00688 Leu_Phe_trans, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR004616 Leu/Phe-tRNA_Trfase
PANTHERiPTHR30098 PTHR30098, 1 hit
PfamiView protein in Pfam
PF03588 Leu_Phe_trans, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
TIGRFAMsiTIGR00667 aat, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZGD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVTQLSSQS FIFPSPELAL REPNGLLALG GDLTAPRLLA AYQRGIFPWF
60 70 80 90 100
NPGEMILWWS PDPRAVLFPE DLHISRSMRR FIRHCPYRFT LNHAFADVIS
110 120 130 140 150
ACATERDEGT WIGRDVQQAY CQLHALGHAH SLEVWLENEL VGGLYGVAVG
160 170 180 190 200
AVFCGESMFS RADNASKSAL MVFCHHFTQH GGELIDCQVL NAHTASLGAV
210 220 230
EIPRNFFLQQ LSQLQFSPLP AECWLPQSLN FSSAMQ
Length:236
Mass (Da):26,403
Last modified:March 1, 2002 - v1
Checksum:i19B93E1B026F2547
GO

Sequence cautioni

The sequence AAM86357 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAS61465 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL20023.1
AE009952 Genomic DNA Translation: AAM86357.1 Different initiation.
AE017042 Genomic DNA Translation: AAS61465.1 Different initiation.
PIRiAE0167
RefSeqiWP_002211346.1, NZ_PDBR01000084.1
YP_002346394.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM86357; AAM86357; y2806
AAS61465; AAS61465; YP_1222
GeneIDi1174212
KEGGiype:YPO1371
ypk:y2806
ypl:CH46_3758
ypm:YP_1222
ypv:BZ15_2183
ypw:CH59_471
PATRICifig|214092.21.peg.1692

Entry informationi

Entry nameiLFTR_YERPE
AccessioniPrimary (citable) accession number: Q8ZGD2
Secondary accession number(s): Q0WH44, Q8D042
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health