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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi376 – 383ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:YPO1395, y2777, YP_1198
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalUniRule annotationAdd BLAST21
Transmembranei69 – 89HelicalUniRule annotationAdd BLAST21
Transmembranei137 – 159HelicalUniRule annotationAdd BLAST23
Transmembranei164 – 186HelicalUniRule annotationAdd BLAST23
Transmembranei253 – 273HelicalUniRule annotationAdd BLAST21
Transmembranei275 – 295HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000926101 – 582Lipid A export ATP-binding/permease protein MsbAAdd BLAST582

Proteomic databases

PRIDEiQ8ZGA9.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiQ8ZGA9. 1 interactor.
STRINGi187410.y2777.

Structurei

3D structure databases

ProteinModelPortaliQ8ZGA9.
SMRiQ8ZGA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 310ABC transmembrane type-1UniRule annotationAdd BLAST284
Domaini342 – 578ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZGA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNDKDLSTW QTFRRLWPTI SPYKAGLIVA AIALILNAAS DTFMLSLLKP
60 70 80 90 100
LLDDGFGNSN SSILKWMPLA VIGLMVVRGV TGFVSSYCIS WVSGKVVMHI
110 120 130 140 150
RRRLFSHMMG MPVSFFDQQS TGTLLSRITY DSEQVAASSS SALVTVVREG
160 170 180 190 200
ASIIGLFIMM FYYSWQLSLI LIVIAPIVSI SIRLVSKRFR NISKNMQNTM
210 220 230 240 250
GEVTTSAEQM LKGHKEVLIF GGQKVETERF DAVSNRMRQQ GMKLVSASSI
260 270 280 290 300
SDPIIQLIAS FALALVLYAA SFPSVMETLT AGTITVVFSA MIALMRPLKS
310 320 330 340 350
LTNVNTQFQR GMAACQTLFS ILDMEQEKDE GKLEVERAKG DIEFRHVTFY
360 370 380 390 400
YPGKDTPALN DINIHLEAGK TVALVGRSGS GKSTIANLLT RFYDVSEGSI
410 420 430 440 450
LLDGHDLRDY RLGALRNQVA LVSQNVHLFN DTVANNIAYA RNEQYSRAEI
460 470 480 490 500
EEAARMAYAM DFINKMEHGL DTVIGENGIM LSGGQRQRIA IARALLRNCP
510 520 530 540 550
ILILDEATSA LDTESERAIQ AALDELQKNR TSLVIAHRLS TIEKADEIVV
560 570 580
IEDGRIVERG VHAELLVQQG VYAQLNRMQF GQ
Length:582
Mass (Da):64,462
Last modified:March 1, 2002 - v1
Checksum:i12FA0E34D64D2C6A
GO

Sequence cautioni

The sequence AAS61441 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL20047.1.
AE009952 Genomic DNA. Translation: AAM86329.1.
AE017042 Genomic DNA. Translation: AAS61441.1. Different initiation.
PIRiAE0170.
RefSeqiWP_002211320.1. NZ_LT605019.1.
YP_002346418.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM86329; AAM86329; y2777.
AAS61441; AAS61441; YP_1198.
GeneIDi1174236.
KEGGiype:YPO1395.
ypk:y2777.
ypm:YP_1198.
PATRICifig|214092.21.peg.1718.

Similar proteinsi

Entry informationi

Entry nameiMSBA_YERPE
AccessioniPrimary (citable) accession number: Q8ZGA9
Secondary accession number(s): Q0WH20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2002
Last modified: October 25, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families