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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB), Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:YPO1413, y2757, YP_1180
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002058551 – 401Nicotinate phosphoribosyltransferaseAdd BLAST401

Proteomic databases

PaxDbiQ8ZG93

Interactioni

Protein-protein interaction databases

STRINGi187410.y2757

Structurei

Secondary structure

1401
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi14 – 16Combined sources3
Helixi17 – 29Combined sources13
Beta strandi34 – 41Combined sources8
Helixi48 – 50Combined sources3
Helixi51 – 61Combined sources11
Helixi68 – 75Combined sources8
Beta strandi77 – 79Combined sources3
Helixi82 – 90Combined sources9
Helixi95 – 97Combined sources3
Beta strandi98 – 103Combined sources6
Beta strandi106 – 114Combined sources9
Helixi115 – 118Combined sources4
Helixi122 – 137Combined sources16
Helixi143 – 160Combined sources18
Turni161 – 163Combined sources3
Beta strandi171 – 173Combined sources3
Helixi182 – 195Combined sources14
Beta strandi199 – 204Combined sources6
Helixi205 – 211Combined sources7
Helixi221 – 227Combined sources7
Turni228 – 230Combined sources3
Beta strandi231 – 233Combined sources3
Helixi234 – 236Combined sources3
Helixi237 – 248Combined sources12
Beta strandi250 – 253Combined sources4
Beta strandi255 – 257Combined sources3
Helixi263 – 269Combined sources7
Helixi272 – 277Combined sources6
Beta strandi280 – 283Combined sources4
Helixi288 – 301Combined sources14
Helixi306 – 308Combined sources3
Beta strandi309 – 313Combined sources5
Helixi319 – 329Combined sources11
Turni330 – 332Combined sources3
Beta strandi333 – 339Combined sources7
Helixi341 – 344Combined sources4
Beta strandi355 – 362Combined sources8
Helixi382 – 391Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3OS4X-ray1.60A/B1-401[»]
ProteinModelPortaliQ8ZG93
SMRiQ8ZG93
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8ZG93

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RH7 Bacteria
COG1488 LUCA
HOGENOMiHOG000284928
KOiK00763
OMAiKLTMQCA

Family and domain databases

CDDicd01401 PncB_like, 1 hit
HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZG93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQDASPILT SLLDTDAYKL HMQQAVFHHY RHITVAAEFR CRSDELLGVY
60 70 80 90 100
ADEIRHQVTL MGQLALTSDE FIYLSSLPFF QDDYLHWLRD FRFKPEQVSV
110 120 130 140 150
AVHDGKLDIR IAGLWCEVIM WEVPLLAVIS EIVHRRRSTQ VTTDQAVQQL
160 170 180 190 200
RTKLEQFNAL SADIDITHFK LMDFGTRRRF SREIQHTVVS TLKDEFPYLV
210 220 230 240 250
GTSNYDLART LALAPVGTQA HEWFQAHQQI SPTLANSQRV ALQVWLDEYP
260 270 280 290 300
NQLGIALTDC ITMDAFLRDF DLAFANRYQG LRHDSGDPIE WGEKAIAHYE
310 320 330 340 350
KLGIDPMKKV LVFSDNLDLE KALFLYRHFY QRIKLVFGIG TRLTCDIPDV
360 370 380 390 400
KPLNIVIKLV ECNDKPVAKL SDSPGKTICQ DPAFVDQLRK AFALPLVKKA

S
Length:401
Mass (Da):46,022
Last modified:March 1, 2002 - v1
Checksum:i88B37431DA649F2D
GO

Sequence cautioni

The sequence AAM86309 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAS61423 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL20065.1
AE009952 Genomic DNA Translation: AAM86309.1 Different initiation.
AE017042 Genomic DNA Translation: AAS61423.1 Different initiation.
PIRiAG0172
RefSeqiWP_002228013.1, NZ_PDBR01000070.1
YP_002346436.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM86309; AAM86309; y2757
AAS61423; AAS61423; YP_1180
GeneIDi1174254
KEGGiype:YPO1413
ypk:y2757
ypm:YP_1180
PATRICifig|214092.21.peg.1740

Similar proteinsi

Entry informationi

Entry nameiPNCB_YERPE
AccessioniPrimary (citable) accession number: Q8ZG93
Secondary accession number(s): Q0WH02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health