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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathway: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciYPES214092:GKDD-1400-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:YPO1413, y2757, YP_1180
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815 Componenti: Chromosome UP000002490 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Nicotinate phosphoribosyltransferasePRO_0000205855Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi214092.YPO1413.

Structurei

Secondary structure

1
401
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi14 – 163Combined sources
Helixi17 – 2913Combined sources
Beta strandi34 – 418Combined sources
Helixi48 – 503Combined sources
Helixi51 – 6111Combined sources
Helixi68 – 758Combined sources
Beta strandi77 – 793Combined sources
Helixi82 – 909Combined sources
Helixi95 – 973Combined sources
Beta strandi98 – 1036Combined sources
Beta strandi106 – 1149Combined sources
Helixi115 – 1184Combined sources
Helixi122 – 13716Combined sources
Helixi143 – 16018Combined sources
Turni161 – 1633Combined sources
Beta strandi171 – 1733Combined sources
Helixi182 – 19514Combined sources
Beta strandi199 – 2046Combined sources
Helixi205 – 2117Combined sources
Helixi221 – 2277Combined sources
Turni228 – 2303Combined sources
Beta strandi231 – 2333Combined sources
Helixi234 – 2363Combined sources
Helixi237 – 24812Combined sources
Beta strandi250 – 2534Combined sources
Beta strandi255 – 2573Combined sources
Helixi263 – 2697Combined sources
Helixi272 – 2776Combined sources
Beta strandi280 – 2834Combined sources
Helixi288 – 30114Combined sources
Helixi306 – 3083Combined sources
Beta strandi309 – 3135Combined sources
Helixi319 – 32911Combined sources
Turni330 – 3323Combined sources
Beta strandi333 – 3397Combined sources
Helixi341 – 3444Combined sources
Beta strandi355 – 3628Combined sources
Helixi382 – 39110Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3OS4X-ray1.60A/B1-401[»]
ProteinModelPortaliQ8ZG93.
SMRiQ8ZG93. Positions 5-377.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8ZG93.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiKLTMQCA.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZG93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQDASPILT SLLDTDAYKL HMQQAVFHHY RHITVAAEFR CRSDELLGVY
60 70 80 90 100
ADEIRHQVTL MGQLALTSDE FIYLSSLPFF QDDYLHWLRD FRFKPEQVSV
110 120 130 140 150
AVHDGKLDIR IAGLWCEVIM WEVPLLAVIS EIVHRRRSTQ VTTDQAVQQL
160 170 180 190 200
RTKLEQFNAL SADIDITHFK LMDFGTRRRF SREIQHTVVS TLKDEFPYLV
210 220 230 240 250
GTSNYDLART LALAPVGTQA HEWFQAHQQI SPTLANSQRV ALQVWLDEYP
260 270 280 290 300
NQLGIALTDC ITMDAFLRDF DLAFANRYQG LRHDSGDPIE WGEKAIAHYE
310 320 330 340 350
KLGIDPMKKV LVFSDNLDLE KALFLYRHFY QRIKLVFGIG TRLTCDIPDV
360 370 380 390 400
KPLNIVIKLV ECNDKPVAKL SDSPGKTICQ DPAFVDQLRK AFALPLVKKA

S
Length:401
Mass (Da):46,022
Last modified:March 1, 2002 - v1
Checksum:i88B37431DA649F2D
GO

Sequence cautioni

The sequence AAM86309.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAS61423.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL20065.1.
AE009952 Genomic DNA. Translation: AAM86309.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS61423.1. Different initiation.
PIRiAG0172.
RefSeqiNP_670058.1. NC_004088.1.
NP_992546.1. NC_005810.1.
WP_002228013.1. NZ_KN150725.1.
YP_002346436.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM86309; AAM86309; y2757.
AAS61423; AAS61423; YP_1180.
GeneIDi1174254.
KEGGiype:YPO1413.
ypk:y2757.
ypm:YP_1180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL20065.1.
AE009952 Genomic DNA. Translation: AAM86309.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS61423.1. Different initiation.
PIRiAG0172.
RefSeqiNP_670058.1. NC_004088.1.
NP_992546.1. NC_005810.1.
WP_002228013.1. NZ_KN150725.1.
YP_002346436.1. NC_003143.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3OS4X-ray1.60A/B1-401[»]
ProteinModelPortaliQ8ZG93.
SMRiQ8ZG93. Positions 5-377.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi214092.YPO1413.

Protocols and materials databases

DNASUi1147704.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM86309; AAM86309; y2757.
AAS61423; AAS61423; YP_1180.
GeneIDi1174254.
KEGGiype:YPO1413.
ypk:y2757.
ypm:YP_1180.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiKLTMQCA.
OrthoDBiEOG6X10XB.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.
BioCyciYPES214092:GKDD-1400-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ8ZG93.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiPNCB_YERPE
AccessioniPrimary (citable) accession number: Q8ZG93
Secondary accession number(s): Q0WH02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: March 1, 2002
Last modified: June 24, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.