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Q8ZG93

- PNCB_YERPE

UniProt

Q8ZG93 - PNCB_YERPE

Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Yersinia pestis
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciYPES214092:GKDD-1400-MONOMER.
    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
    Short name:
    NAPRTaseUniRule annotation
    Gene namesi
    Name:pncBUniRule annotation
    Ordered Locus Names:YPO1413, y2757, YP_1180
    OrganismiYersinia pestis
    Taxonomic identifieri632 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 401401Nicotinate phosphoribosyltransferasePRO_0000205855Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi214092.YPO1413.

    Structurei

    Secondary structure

    1
    401
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi14 – 163
    Helixi17 – 2913
    Beta strandi34 – 418
    Helixi48 – 503
    Helixi51 – 6111
    Helixi68 – 758
    Beta strandi77 – 793
    Helixi82 – 909
    Helixi95 – 973
    Beta strandi98 – 1036
    Beta strandi106 – 1149
    Helixi115 – 1184
    Helixi122 – 13716
    Helixi143 – 16018
    Turni161 – 1633
    Beta strandi171 – 1733
    Helixi182 – 19514
    Beta strandi199 – 2046
    Helixi205 – 2117
    Helixi221 – 2277
    Turni228 – 2303
    Beta strandi231 – 2333
    Helixi234 – 2363
    Helixi237 – 24812
    Beta strandi250 – 2534
    Beta strandi255 – 2573
    Helixi263 – 2697
    Helixi272 – 2776
    Beta strandi280 – 2834
    Helixi288 – 30114
    Helixi306 – 3083
    Beta strandi309 – 3135
    Helixi319 – 32911
    Turni330 – 3323
    Beta strandi333 – 3397
    Helixi341 – 3444
    Beta strandi355 – 3628
    Helixi382 – 39110

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3OS4X-ray1.60A/B1-401[»]
    ProteinModelPortaliQ8ZG93.
    SMRiQ8ZG93. Positions 5-377.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8ZG93.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1488.
    HOGENOMiHOG000284928.
    KOiK00763.
    OMAiQAVFHRY.
    OrthoDBiEOG6X10XB.

    Family and domain databases

    HAMAPiMF_00570. NAPRTase.
    InterProiIPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 1 hit.
    TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8ZG93-1 [UniParc]FASTAAdd to Basket

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    MTQDASPILT SLLDTDAYKL HMQQAVFHHY RHITVAAEFR CRSDELLGVY    50
    ADEIRHQVTL MGQLALTSDE FIYLSSLPFF QDDYLHWLRD FRFKPEQVSV 100
    AVHDGKLDIR IAGLWCEVIM WEVPLLAVIS EIVHRRRSTQ VTTDQAVQQL 150
    RTKLEQFNAL SADIDITHFK LMDFGTRRRF SREIQHTVVS TLKDEFPYLV 200
    GTSNYDLART LALAPVGTQA HEWFQAHQQI SPTLANSQRV ALQVWLDEYP 250
    NQLGIALTDC ITMDAFLRDF DLAFANRYQG LRHDSGDPIE WGEKAIAHYE 300
    KLGIDPMKKV LVFSDNLDLE KALFLYRHFY QRIKLVFGIG TRLTCDIPDV 350
    KPLNIVIKLV ECNDKPVAKL SDSPGKTICQ DPAFVDQLRK AFALPLVKKA 400
    S 401
    Length:401
    Mass (Da):46,022
    Last modified:March 1, 2002 - v1
    Checksum:i88B37431DA649F2D
    GO

    Sequence cautioni

    The sequence AAM86309.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAS61423.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL20065.1.
    AE009952 Genomic DNA. Translation: AAM86309.1. Different initiation.
    AE017042 Genomic DNA. Translation: AAS61423.1. Different initiation.
    PIRiAG0172.
    RefSeqiNP_670058.1. NC_004088.1.
    NP_992546.1. NC_005810.1.
    YP_002346436.1. NC_003143.1.

    Genome annotation databases

    EnsemblBacteriaiAAM86309; AAM86309; y2757.
    AAS61423; AAS61423; YP_1180.
    GeneIDi1147704.
    1174254.
    2763470.
    KEGGiype:YPO1413.
    ypk:y2757.
    ypm:YP_1180.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL20065.1 .
    AE009952 Genomic DNA. Translation: AAM86309.1 . Different initiation.
    AE017042 Genomic DNA. Translation: AAS61423.1 . Different initiation.
    PIRi AG0172.
    RefSeqi NP_670058.1. NC_004088.1.
    NP_992546.1. NC_005810.1.
    YP_002346436.1. NC_003143.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3OS4 X-ray 1.60 A/B 1-401 [» ]
    ProteinModelPortali Q8ZG93.
    SMRi Q8ZG93. Positions 5-377.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 214092.YPO1413.

    Protocols and materials databases

    DNASUi 1147704.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM86309 ; AAM86309 ; y2757 .
    AAS61423 ; AAS61423 ; YP_1180 .
    GeneIDi 1147704.
    1174254.
    2763470.
    KEGGi ype:YPO1413.
    ypk:y2757.
    ypm:YP_1180.

    Phylogenomic databases

    eggNOGi COG1488.
    HOGENOMi HOG000284928.
    KOi K00763.
    OMAi QAVFHRY.
    OrthoDBi EOG6X10XB.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .
    BioCyci YPES214092:GKDD-1400-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q8ZG93.

    Family and domain databases

    HAMAPi MF_00570. NAPRTase.
    InterProi IPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 1 hit.
    TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CO-92 / Biovar Orientalis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIM10+ / Biovar Mediaevalis.
    3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
      Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
      , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
      DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 91001 / Biovar Mediaevalis.

    Entry informationi

    Entry nameiPNCB_YERPE
    AccessioniPrimary (citable) accession number: Q8ZG93
    Secondary accession number(s): Q0WH02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3