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Protein

GTP cyclohydrolase 1

Gene

folE

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase 1 (folE), GTP cyclohydrolase 1 (folE)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi109 – 1091ZincUniRule annotation
Metal bindingi112 – 1121ZincUniRule annotation
Metal bindingi180 – 1801ZincUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciYPES214092:GKDD-1486-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1UniRule annotation (EC:3.5.4.16UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IUniRule annotation
Short name:
GTP-CH-IUniRule annotation
Gene namesi
Name:folEUniRule annotation
Ordered Locus Names:YPO1505, y2664, YP_1395
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220GTP cyclohydrolase 1PRO_0000119470Add
BLAST

Proteomic databases

PRIDEiQ8ZG15.

Interactioni

Subunit structurei

Toroid-shaped homodecamer, composed of two pentamers of five dimers.By similarity

Protein-protein interaction databases

STRINGi187410.y2664.

Structurei

Secondary structure

1
220
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 1813Combined sources
Helixi31 – 4818Combined sources
Turni56 – 605Combined sources
Helixi61 – 7111Combined sources
Turni72 – 743Combined sources
Helixi75 – 773Combined sources
Helixi79 – 813Combined sources
Beta strandi87 – 893Combined sources
Beta strandi98 – 10912Combined sources
Turni110 – 1123Combined sources
Beta strandi115 – 12410Combined sources
Beta strandi127 – 1315Combined sources
Helixi133 – 14412Combined sources
Beta strandi145 – 1484Combined sources
Helixi150 – 16516Combined sources
Beta strandi170 – 1789Combined sources
Helixi179 – 1824Combined sources
Beta strandi192 – 1987Combined sources
Helixi201 – 2044Combined sources
Helixi206 – 21611Combined sources
Turni217 – 2193Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DU6X-ray2.11A/B/C/D/E1-220[»]
ProteinModelPortaliQ8ZG15.
SMRiQ8ZG15. Positions 3-219.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase I family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EUJ. Bacteria.
COG0302. LUCA.
HOGENOMiHOG000221222.
KOiK01495.
OMAiISGHMTE.

Family and domain databases

HAMAPiMF_00223. FolE. 1 hit.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZG15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLSKEAEL VHQALLARGL ETPLRKPELD AETRKTRIQA HMTEVMHLLN
60 70 80 90 100
LDLTDDSLAD TPRRIAKMYV DEIFSGLDYE NFPKITLIQN KMKVDEMVTV
110 120 130 140 150
RDITLTSTCE HHFVTIDGKA TVAYIPKDSV IGLSKINRIV QFFAQRPQVQ
160 170 180 190 200
ERLTQQILLA LQTLLGTNNV AVSIDAVHYC VKARGIRDAT SATTTTSLGG
210 220
LFKSSQNTRQ EFLRAVRHHG
Length:220
Mass (Da):24,714
Last modified:March 1, 2002 - v1
Checksum:i5B497C8B4FA301F8
GO

Sequence cautioni

The sequence AAM86217 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAS61636 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL20151.1.
AE009952 Genomic DNA. Translation: AAM86217.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS61636.1. Different initiation.
PIRiAE0183.
RefSeqiWP_002211960.1. NZ_LQAY01000058.1.
YP_002346521.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM86217; AAM86217; y2664.
AAS61636; AAS61636; YP_1395.
GeneIDi1174344.
KEGGiype:YPO1505.
ypj:CH55_1032.
ypk:y2664.
ypl:CH46_3621.
ypm:YP_1395.
ypv:BZ15_2048.
ypw:CH59_333.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL20151.1.
AE009952 Genomic DNA. Translation: AAM86217.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS61636.1. Different initiation.
PIRiAE0183.
RefSeqiWP_002211960.1. NZ_LQAY01000058.1.
YP_002346521.1. NC_003143.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DU6X-ray2.11A/B/C/D/E1-220[»]
ProteinModelPortaliQ8ZG15.
SMRiQ8ZG15. Positions 3-219.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187410.y2664.

Proteomic databases

PRIDEiQ8ZG15.

Protocols and materials databases

DNASUi1147611.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM86217; AAM86217; y2664.
AAS61636; AAS61636; YP_1395.
GeneIDi1174344.
KEGGiype:YPO1505.
ypj:CH55_1032.
ypk:y2664.
ypl:CH46_3621.
ypm:YP_1395.
ypv:BZ15_2048.
ypw:CH59_333.

Phylogenomic databases

eggNOGiENOG4105EUJ. Bacteria.
COG0302. LUCA.
HOGENOMiHOG000221222.
KOiK01495.
OMAiISGHMTE.

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.
BioCyciYPES214092:GKDD-1486-MONOMER.

Family and domain databases

HAMAPiMF_00223. FolE. 1 hit.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGCH1_YERPE
AccessioniPrimary (citable) accession number: Q8ZG15
Secondary accession number(s): Q0WGR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.