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Protein

GTP cyclohydrolase 1

Gene

folE

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase 1 (folE), GTP cyclohydrolase 1 (folE)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi109ZincUniRule annotation1
Metal bindingi112ZincUniRule annotation1
Metal bindingi180ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandGTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1UniRule annotation (EC:3.5.4.16UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IUniRule annotation
Short name:
GTP-CH-IUniRule annotation
Gene namesi
Name:folEUniRule annotation
Ordered Locus Names:YPO1505, y2664, YP_1395
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001194701 – 220GTP cyclohydrolase 1Add BLAST220

Proteomic databases

PaxDbiQ8ZG15
PRIDEiQ8ZG15

Interactioni

Subunit structurei

Toroid-shaped homodecamer, composed of two pentamers of five dimers.By similarity

Protein-protein interaction databases

STRINGi187410.y2664

Structurei

Secondary structure

1220
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 18Combined sources13
Helixi31 – 48Combined sources18
Turni56 – 60Combined sources5
Helixi61 – 71Combined sources11
Turni72 – 74Combined sources3
Helixi75 – 77Combined sources3
Helixi79 – 81Combined sources3
Beta strandi87 – 89Combined sources3
Beta strandi98 – 109Combined sources12
Turni110 – 112Combined sources3
Beta strandi115 – 124Combined sources10
Beta strandi127 – 131Combined sources5
Helixi133 – 144Combined sources12
Beta strandi145 – 148Combined sources4
Helixi150 – 165Combined sources16
Beta strandi170 – 178Combined sources9
Helixi179 – 182Combined sources4
Beta strandi192 – 198Combined sources7
Helixi201 – 204Combined sources4
Helixi206 – 216Combined sources11
Turni217 – 219Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DU6X-ray2.11A/B/C/D/E1-220[»]
ProteinModelPortaliQ8ZG15
SMRiQ8ZG15
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase I family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EUJ Bacteria
COG0302 LUCA
HOGENOMiHOG000221222
KOiK01495
OMAiIVVVECE

Family and domain databases

HAMAPiMF_00223 FolE, 1 hit
InterProiView protein in InterPro
IPR001474 GTP_CycHdrlase_I
IPR018234 GTP_CycHdrlase_I_CS
IPR020602 GTP_CycHdrlase_I_dom
PANTHERiPTHR11109 PTHR11109, 1 hit
PfamiView protein in Pfam
PF01227 GTP_cyclohydroI, 1 hit
TIGRFAMsiTIGR00063 folE, 1 hit
PROSITEiView protein in PROSITE
PS00859 GTP_CYCLOHYDROL_1_1, 1 hit
PS00860 GTP_CYCLOHYDROL_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZG15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLSKEAEL VHQALLARGL ETPLRKPELD AETRKTRIQA HMTEVMHLLN
60 70 80 90 100
LDLTDDSLAD TPRRIAKMYV DEIFSGLDYE NFPKITLIQN KMKVDEMVTV
110 120 130 140 150
RDITLTSTCE HHFVTIDGKA TVAYIPKDSV IGLSKINRIV QFFAQRPQVQ
160 170 180 190 200
ERLTQQILLA LQTLLGTNNV AVSIDAVHYC VKARGIRDAT SATTTTSLGG
210 220
LFKSSQNTRQ EFLRAVRHHG
Length:220
Mass (Da):24,714
Last modified:March 1, 2002 - v1
Checksum:i5B497C8B4FA301F8
GO

Sequence cautioni

The sequence AAM86217 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAS61636 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL20151.1
AE009952 Genomic DNA Translation: AAM86217.1 Different initiation.
AE017042 Genomic DNA Translation: AAS61636.1 Different initiation.
PIRiAE0183
RefSeqiWP_002211960.1, NZ_PDBR01000058.1
YP_002346521.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM86217; AAM86217; y2664
AAS61636; AAS61636; YP_1395
GeneIDi1174344
KEGGiype:YPO1505
ypk:y2664
ypm:YP_1395
PATRICifig|214092.21.peg.1836

Similar proteinsi

Entry informationi

Entry nameiGCH1_YERPE
AccessioniPrimary (citable) accession number: Q8ZG15
Secondary accession number(s): Q0WGR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health