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Protein

Deoxycytidine triphosphate deaminase

Gene

dcd

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathway: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Deoxycytidine triphosphate deaminase (dcd)
  2. Deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Enzyme and pathway databases

BioCyciYPES214092:GKDD-1506-MONOMER.
UniPathwayiUPA00610; UER00665.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxycytidine triphosphate deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Short name:
dCTP deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:YPO1525, y2645, YP_1414
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815 Componenti: Chromosome UP000002490 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Deoxycytidine triphosphate deaminasePRO_0000156024Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi214092.YPO1525.

Structurei

3D structure databases

ProteinModelPortaliQ8ZFZ8.
SMRiQ8ZFZ8. Positions 1-193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0717.
HOGENOMiHOG000228601.
KOiK01494.
OMAiRQDAKYK.
OrthoDBiEOG67DPKR.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00146. dCTP_deaminase.
InterProiIPR011962. dCTP_deam.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZFZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLCDRDIEA WLDSGKLGIE PRPPVERING ATVDVRLGNQ FRVFRGHTAA
60 70 80 90 100
FIDLSGPKDE VSAALERVMS DEINLPEGEA FFLHPGELAL AVTLESVTIP
110 120 130 140 150
DDLVGWLDGR SSLARLGLMV HVTAHRIDPG WQGRIVLEFY NSGKLPLALR
160 170 180 190
PGMLIGALSF EPLSGPAARP YNSRQDAKYR GQQGAVASRI DKD
Length:193
Mass (Da):21,140
Last modified:March 27, 2002 - v1
Checksum:iAF09C4C83A623BCE
GO

Sequence cautioni

The sequence AAM86198.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAS61655.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL20171.1.
AE009952 Genomic DNA. Translation: AAM86198.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS61655.1. Different initiation.
PIRiAI0185.
RefSeqiWP_002211873.1. NZ_KN150725.1.
YP_002346541.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM86198; AAM86198; y2645.
AAS61655; AAS61655; YP_1414.
GeneIDi1174364.
KEGGiype:YPO1525.
PATRICi18592478. VBIYerPes7843_1959.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL20171.1.
AE009952 Genomic DNA. Translation: AAM86198.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS61655.1. Different initiation.
PIRiAI0185.
RefSeqiWP_002211873.1. NZ_KN150725.1.
YP_002346541.1. NC_003143.1.

3D structure databases

ProteinModelPortaliQ8ZFZ8.
SMRiQ8ZFZ8. Positions 1-193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi214092.YPO1525.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM86198; AAM86198; y2645.
AAS61655; AAS61655; YP_1414.
GeneIDi1174364.
KEGGiype:YPO1525.
PATRICi18592478. VBIYerPes7843_1959.

Phylogenomic databases

eggNOGiCOG0717.
HOGENOMiHOG000228601.
KOiK01494.
OMAiRQDAKYK.
OrthoDBiEOG67DPKR.

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665.
BioCyciYPES214092:GKDD-1506-MONOMER.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00146. dCTP_deaminase.
InterProiIPR011962. dCTP_deam.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiDCD_YERPE
AccessioniPrimary (citable) accession number: Q8ZFZ8
Secondary accession number(s): Q0WGP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: June 24, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.