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Q8ZFX5

- HISX_YERPE

UniProt

Q8ZFX5 - HISX_YERPE

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Protein
Histidinol dehydrogenase
Gene
hisD, YPO1548, y2621, YP_1437
Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei133 – 1331NAD By similarity
Binding sitei191 – 1911NAD By similarity
Binding sitei214 – 2141NAD By similarity
Binding sitei240 – 2401Substrate By similarity
Metal bindingi262 – 2621Zinc By similarity
Binding sitei262 – 2621Substrate By similarity
Metal bindingi265 – 2651Zinc By similarity
Binding sitei265 – 2651Substrate By similarity
Active sitei329 – 3291Proton acceptor By similarity
Active sitei330 – 3301Proton acceptor By similarity
Binding sitei330 – 3301Substrate By similarity
Metal bindingi363 – 3631Zinc By similarity
Binding sitei363 – 3631Substrate By similarity
Binding sitei417 – 4171Substrate By similarity
Metal bindingi422 – 4221Zinc By similarity
Binding sitei422 – 4221Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciYPES214092:GKDD-1529-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:YPO1548, y2621, YP_1437
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Histidinol dehydrogenaseUniRule annotation
PRO_0000135887Add
BLAST

Proteomic databases

PRIDEiQ8ZFX5.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

IntActiQ8ZFX5. 10 interactions.
STRINGi214092.YPO1548.

Structurei

3D structure databases

ProteinModelPortaliQ8ZFX5.
SMRiQ8ZFX5. Positions 5-433.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZFX5-1 [UniParc]FASTAAdd to Basket

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MQPTNFNTLI NWQQCSEEQQ KALLSRPAIN ASERITAAVS DILDRVKAEG    50
DSALRDFSQR FDHVQVADIR ITASEIAAAS ARLSDDVKHA MAQAVRNIEI 100
FHNAQKMPVV DVETQPGVRC QQITRPIASV GLYIPGGSAP LPSTVLMLGT 150
PARIAGCQRV VLCSPPPIAD EILYAAQLCG IQEVFQIGGA QAIAAMAFGS 200
ESVPKVHKIF GPGNAYVTEA KRQVSQRLDG AAIDMPAGPS EVLVIADSGA 250
TPAFIAADLL SQAEHGPDSQ VILLTPDAAI AQAVAVEVEQ QLALLSRADI 300
ARQALESSRL IVTNDLQQCI DISNAYGPEH LILQIRQPEE IIDQIDNAGS 350
VFMGDWSPES AGDYASGTNH VLPTYGYTST YSSLGLADFV KRMTVQQLTP 400
QGLLGLASTI ETLAQAEQLT AHKNAVTLRV TALNNALTAV NKE 443
Length:443
Mass (Da):47,233
Last modified:March 1, 2002 - v1
Checksum:iE4841C0ACE54772C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL20194.1.
AE009952 Genomic DNA. Translation: AAM86175.1.
AE017042 Genomic DNA. Translation: AAS61678.1.
PIRiAH0188.
RefSeqiNP_669924.1. NC_004088.1.
NP_992801.1. NC_005810.1.
YP_002346564.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM86175; AAM86175; y2621.
AAS61678; AAS61678; YP_1437.
GeneIDi1147568.
1174387.
2765680.
KEGGiype:YPO1548.
ypk:y2621.
ypm:YP_1437.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL20194.1 .
AE009952 Genomic DNA. Translation: AAM86175.1 .
AE017042 Genomic DNA. Translation: AAS61678.1 .
PIRi AH0188.
RefSeqi NP_669924.1. NC_004088.1.
NP_992801.1. NC_005810.1.
YP_002346564.1. NC_003143.1.

3D structure databases

ProteinModelPortali Q8ZFX5.
SMRi Q8ZFX5. Positions 5-433.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8ZFX5. 10 interactions.
STRINGi 214092.YPO1548.

Proteomic databases

PRIDEi Q8ZFX5.

Protocols and materials databases

DNASUi 1147568.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM86175 ; AAM86175 ; y2621 .
AAS61678 ; AAS61678 ; YP_1437 .
GeneIDi 1147568.
1174387.
2765680.
KEGGi ype:YPO1548.
ypk:y2621.
ypm:YP_1437.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci YPES214092:GKDD-1529-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiHISX_YERPE
AccessioniPrimary (citable) accession number: Q8ZFX5
Secondary accession number(s): Q0WGM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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