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Q8ZFV8

- LLDD_YERPE

UniProt

Q8ZFV8 - LLDD_YERPE

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Protein
L-lactate dehydrogenase
Gene
lldD, YPO1569, y2596, YP_1457
Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain By similarity.

Catalytic activityi

(S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.

Cofactori

FMN By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei24 – 241Substrate Reviewed prediction
Binding sitei106 – 1061FMN By similarity
Binding sitei127 – 1271FMN By similarity
Binding sitei129 – 1291Substrate By similarity
Binding sitei155 – 1551FMN By similarity
Binding sitei164 – 1641Substrate By similarity
Binding sitei251 – 2511FMN By similarity
Active sitei275 – 2751Proton acceptor By similarity
Binding sitei278 – 2781Substrate Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi306 – 33025FMN By similarity
Add
BLAST

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. L-lactate dehydrogenase (cytochrome) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lactate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

BioCyciYPES214092:GKDD-1549-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase (EC:1.1.-.-)
Gene namesi
Name:lldD
Ordered Locus Names:YPO1569, y2596, YP_1457
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

Subcellular locationi

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381L-lactate dehydrogenase
PRO_0000206359Add
BLAST

Proteomic databases

PRIDEiQ8ZFV8.

Interactioni

Protein-protein interaction databases

STRINGi214092.YPO1569.

Structurei

3D structure databases

ProteinModelPortaliQ8ZFV8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 380380FMN hydroxy acid dehydrogenase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1304.
HOGENOMiHOG000217464.
KOiK00101.
OMAiDCTLLGR.
OrthoDBiEOG6HMXBG.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01559. L_lact_dehydr.
InterProiIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
IPR020920. L-lactate_DHase_bac.
[Graphical view]
PfamiPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEiPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZFV8-1 [UniParc]FASTAAdd to Basket

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MIISASTDYR AAAQRKLPPF LFHYIDGGAY NEQTLRRNTA DLADIALRQR    50
VLKNMSELSL ETQLFGETQA MPVVLGPVGL SGMYARRGEV QAARAADKKG 100
IPFTLSTLSV CPIEEVAPAI ARPMWFQLYV LKDRGFMRNA LTRAQAAGVK 150
TLVFTVDMPV PGARYRDAHS GMSGPNAAAR RLLQAIAHPQ WAWDVGLNGK 200
PHDLGNISAY LGKPTTLEDY MGWIATNFDP SISWKDLEWV REFWQGPMII 250
KGILDPEDAK DAVKFGADGI VVSNHGGRQL DGVLSTARAL PAIADAVKGD 300
ITILADSGIR TGLDVVRMIA LGADSVLLGR AFVYALATAG EAGVINLLTL 350
IEQEMRVAMT LTGAKRIADI NRDSLAVSER G 381
Length:381
Mass (Da):41,259
Last modified:March 1, 2002 - v1
Checksum:iECC708A08D5E4634
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL20214.1.
AE009952 Genomic DNA. Translation: AAM86151.1.
AE017042 Genomic DNA. Translation: AAS61696.1.
PIRiAD0191.
RefSeqiNP_669900.1. NC_004088.1.
NP_992819.1. NC_005810.1.
YP_002346582.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM86151; AAM86151; y2596.
AAS61696; AAS61696; YP_1457.
GeneIDi1147543.
1174407.
2767186.
KEGGiype:YPO1569.
ypk:y2596.
ypm:YP_1457.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL20214.1 .
AE009952 Genomic DNA. Translation: AAM86151.1 .
AE017042 Genomic DNA. Translation: AAS61696.1 .
PIRi AD0191.
RefSeqi NP_669900.1. NC_004088.1.
NP_992819.1. NC_005810.1.
YP_002346582.1. NC_003143.1.

3D structure databases

ProteinModelPortali Q8ZFV8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 214092.YPO1569.

Proteomic databases

PRIDEi Q8ZFV8.

Protocols and materials databases

DNASUi 1147543.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM86151 ; AAM86151 ; y2596 .
AAS61696 ; AAS61696 ; YP_1457 .
GeneIDi 1147543.
1174407.
2767186.
KEGGi ype:YPO1569.
ypk:y2596.
ypm:YP_1457.

Phylogenomic databases

eggNOGi COG1304.
HOGENOMi HOG000217464.
KOi K00101.
OMAi DCTLLGR.
OrthoDBi EOG6HMXBG.

Enzyme and pathway databases

BioCyci YPES214092:GKDD-1549-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01559. L_lact_dehydr.
InterProi IPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
IPR020920. L-lactate_DHase_bac.
[Graphical view ]
Pfami PF01070. FMN_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEi PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiLLDD_YERPE
AccessioniPrimary (citable) accession number: Q8ZFV8
Secondary accession number(s): Q0WGK6, Q74V74, Q7CHT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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