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Protein

Argininosuccinate synthase

Gene

argG

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argI), Ornithine carbamoyltransferase (argI)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei43ATP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei99CitrullineBy similarity1
Binding sitei129ATP; via amide nitrogenBy similarity1
Binding sitei131AspartateBy similarity1
Binding sitei131ATPBy similarity1
Binding sitei135AspartateBy similarity1
Binding sitei135CitrullineBy similarity1
Binding sitei136AspartateBy similarity1
Binding sitei136ATPBy similarity1
Binding sitei139CitrullineBy similarity1
Binding sitei192CitrullineBy similarity1
Binding sitei194ATPBy similarity1
Binding sitei201CitrullineBy similarity1
Binding sitei203CitrullineBy similarity1
Binding sitei280CitrullineBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 25ATPBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:YPO1570, y2595, YP_1458
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001487102 – 455Argininosuccinate synthaseAdd BLAST454

Proteomic databases

PaxDbiQ8ZFV7

Interactioni

Subunit structurei

Homotetramer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8ZFV7, 1 interactor
STRINGi187410.y2595

Structurei

3D structure databases

ProteinModelPortaliQ8ZFV7
SMRiQ8ZFV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
HOGENOMiHOG000230094
KOiK01940
OMAiGVGRIDM

Family and domain databases

Gene3Di1.10.287.400, 1 hit
3.40.50.620, 2 hits
3.90.1260.10, 2 hits
HAMAPiMF_00581 Arg_succ_synth_type2, 1 hit
InterProiView protein in InterPro
IPR023437 Arg_succ_synth_type2_subfam
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR024074 AS_cat/multimer_dom_body
IPR024073 AS_multimer_C_tail
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8ZFV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTILKHLPI NQRVGIAFSG GLDTSAALLW MQKKGAIPYA YTANLGQPDE
60 70 80 90 100
EDYEAIPRKA MEYGAEKARL IDCRKQLVAE GIAAIQCGAF HNTTAGVTYF
110 120 130 140 150
NTTPLGRAVT GTMLVAAMKE DDVNIWGDGS TYKGNDIERF YRYGLLTNAE
160 170 180 190 200
LKIYKPWLDT DFIDELGGRH EMSEFMIQSG FDYKMSTEKA YSTDSNMLGA
210 220 230 240 250
THEAKDLEFL NSSVKIVNPI MGVKFWDENV VVKAEEVTVR FERGYPVALN
260 270 280 290 300
GVVFDDSVEL MMEANRIGGR HGLGMSDQIE NRIIEAKSRG IYEAPGMALL
310 320 330 340 350
HIAYERLLTG IHNEDTIEQY HANGRVLGRL LYQGRWFDPQ ALMLRDSIQR
360 370 380 390 400
WVASEITGEV TLELRRGNDY SILNTVSDNL TYKPERLTME KGDSVFSPDD
410 420 430 440 450
RIGQLTMRNL DITDTREKLF NYVETGLLTS SAATGLPQVD NNNLSSGRGL

QDKRQ
Length:455
Mass (Da):51,009
Last modified:January 23, 2007 - v3
Checksum:i7B1A2B828CDAE057
GO

Sequence cautioni

The sequence AAM86150 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAS61697 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL20215.1
AE009952 Genomic DNA Translation: AAM86150.1 Different initiation.
AE017042 Genomic DNA Translation: AAS61697.1 Different initiation.
PIRiAE0191
RefSeqiWP_002211920.1, NZ_PDBR01000062.1
YP_002346583.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM86150; AAM86150; y2595
AAS61697; AAS61697; YP_1458
GeneIDi1174408
KEGGiype:YPO1570
ypj:CH55_968
ypk:y2595
ypl:CH46_3556
ypm:YP_1458
ypv:BZ15_1982
ypw:CH59_256
PATRICifig|214092.21.peg.1911

Similar proteinsi

Entry informationi

Entry nameiASSY_YERPE
AccessioniPrimary (citable) accession number: Q8ZFV7
Secondary accession number(s): Q0WGK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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