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Q8ZFS3

- NAGZ_YERPE

UniProt

Q8ZFS3 - NAGZ_YERPE

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Protein

Beta-hexosaminidase

Gene
nagZ, YPO1615, y1775, YP_2239
Organism
Yersinia pestis
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides By similarity.UniRule annotation

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621Substrate By similarity
Binding sitei70 – 701Substrate By similarity
Binding sitei133 – 1331Substrate By similarity
Sitei174 – 1741Important for catalytic activity By similarity
Active sitei176 – 1761Proton donor/acceptor By similarity
Active sitei248 – 2481Nucleophile By similarity

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cell cycle Source: UniProtKB-KW
  3. cell division Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-KW
  5. peptidoglycan turnover Source: UniProtKB-HAMAP
  6. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciYPES214092:GKDD-1596-MONOMER.
UniPathwayiUPA00544.

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidase (EC:3.2.1.52)
Alternative name(s):
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase
Gene namesi
Name:nagZ
Ordered Locus Names:YPO1615, y1775, YP_2239
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Beta-hexosaminidaseUniRule annotationPRO_0000210806Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi214092.YPO1615.

Structurei

3D structure databases

ProteinModelPortaliQ8ZFS3.
SMRiQ8ZFS3. Positions 1-335.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni163 – 1642Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000248526.
KOiK01207.
OMAiYTEADPR.
OrthoDBiEOG6BCT06.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
HAMAPiMF_00364. NagZ.
InterProiIPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00933. Glyco_hydro_3. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZFS3-1 [UniParc]FASTAAdd to Basket

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MGPVMLDVAS YELDAEEREI LKHPLVGGLI LFSRNFHDAE QLRELVRQIR    50
AASHERLVVA VDQEGGRVQR FRDGFTRLPA AQYFAAINDA ATAAQLAQEA 100
GWLMAAEMMA MDIDISFAPV LDIGHVSAAI GERSFHSDPQ QARIMAECFI 150
RGMHSAGMKT TGKHFPGHGA VTADSHKETP HDNRPLAEIR THDMVIFREL 200
IQRKLLDAIM PAHVIYTEAD ARPASGSAYW LQEILRQELG FEGIIFSDDL 250
SMEGAAIMGS YAERGQASLD AGCDMILVCN NRQGAVSVLD NLSPIKADQL 300
TRLYHSGQFD RQTLMASSRW QQANKALTAL SERWDAHKQT LGQ 343
Length:343
Mass (Da):37,979
Last modified:March 1, 2002 - v1
Checksum:iFC5B6D620DA3B5D2
GO

Sequence cautioni

The sequence AAM85342.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAS62445.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL20260.1.
AE009952 Genomic DNA. Translation: AAM85342.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS62445.1. Different initiation.
PIRiAB0197.
RefSeqiNP_669091.1. NC_004088.1.
NP_993568.1. NC_005810.1.
YP_002346626.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM85342; AAM85342; y1775.
AAS62445; AAS62445; YP_2239.
GeneIDi1146721.
1174454.
2764641.
KEGGiype:YPO1615.
ypk:y1775.
ypm:YP_2239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL20260.1 .
AE009952 Genomic DNA. Translation: AAM85342.1 . Different initiation.
AE017042 Genomic DNA. Translation: AAS62445.1 . Different initiation.
PIRi AB0197.
RefSeqi NP_669091.1. NC_004088.1.
NP_993568.1. NC_005810.1.
YP_002346626.1. NC_003143.1.

3D structure databases

ProteinModelPortali Q8ZFS3.
SMRi Q8ZFS3. Positions 1-335.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 214092.YPO1615.

Protein family/group databases

CAZyi GH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

DNASUi 1146721.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM85342 ; AAM85342 ; y1775 .
AAS62445 ; AAS62445 ; YP_2239 .
GeneIDi 1146721.
1174454.
2764641.
KEGGi ype:YPO1615.
ypk:y1775.
ypm:YP_2239.

Phylogenomic databases

eggNOGi COG1472.
HOGENOMi HOG000248526.
KOi K01207.
OMAi YTEADPR.
OrthoDBi EOG6BCT06.

Enzyme and pathway databases

UniPathwayi UPA00544 .
BioCyci YPES214092:GKDD-1596-MONOMER.

Family and domain databases

Gene3Di 3.20.20.300. 1 hit.
HAMAPi MF_00364. NagZ.
InterProi IPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00933. Glyco_hydro_3. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiNAGZ_YERPE
AccessioniPrimary (citable) accession number: Q8ZFS3
Secondary accession number(s): Q0WGG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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