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Protein

Chemotaxis response regulator protein-glutamate methylesterase

Gene

cheB

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei164UniRule annotation1
Active sitei190UniRule annotation1
Active sitei286UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesteraseUniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheBUniRule annotation
Ordered Locus Names:YPO1679, y1841, YP_1809
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001580471 – 349Chemotaxis response regulator protein-glutamate methylesteraseAdd BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei564-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

IntActiQ8ZFM0. 2 interactors.
STRINGi187410.y1841.

Structurei

3D structure databases

ProteinModelPortaliQ8ZFM0.
SMRiQ8ZFM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 122Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini152 – 344CheB-type methylesteraseUniRule annotationAdd BLAST193

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP. Bacteria.
COG2201. LUCA.
HOGENOMiHOG000151423.
KOiK03412.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZFM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKIRVLCVD DSALMRQLMT EIINSHPDME MVAAAQDPLV ARDLIKKFNP
60 70 80 90 100
QVLTLDVEMP RMDGLDFLEK LMRLRPMPVV MVSSLTGKNS EITMRALELG
110 120 130 140 150
AIDFVTKPQL GIREGMLAYS ELIADKIRTA AKARLPQRVL ENKPAMLSHT
160 170 180 190 200
PLLSSEKLIA IGASTGGTEA IRAVLQPLPP TSPALLITQH MPPGFTRSFA
210 220 230 240 250
ERLNKLCQIT VKEAEDGERV LPGHAYIAPG DRHLELARSG ANYQVRIHDG
260 270 280 290 300
PAVNRHRPSV DVLFRSVAQY AGRNAVGVIL TGMGNDGAAG LLEMHRAGAY
310 320 330 340
TLAQNEASCV VFGMPREAIA MGGVNDVVEL NQISQRMLAQ ISSGQALRI
Length:349
Mass (Da):37,982
Last modified:March 1, 2002 - v1
Checksum:i0DADA92046FB8996
GO

Sequence cautioni

The sequence AAM85407 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAS62034 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL20323.1.
AE009952 Genomic DNA. Translation: AAM85407.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS62034.1. Different initiation.
PIRiAH0204.
RefSeqiWP_002210874.1. NZ_LT605019.1.
YP_002346684.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM85407; AAM85407; y1841.
AAS62034; AAS62034; YP_1809.
GeneIDi1174517.
KEGGiype:YPO1679.
ypj:CH55_254.
ypk:y1841.
ypl:CH46_3447.
ypm:YP_1809.
ypv:BZ15_1873.
ypw:CH59_159.
PATRICifig|214092.21.peg.2024.

Similar proteinsi

Entry informationi

Entry nameiCHEB_YERPE
AccessioniPrimary (citable) accession number: Q8ZFM0
Secondary accession number(s): Q0WGA4, Q8D0P2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: March 1, 2002
Last modified: November 22, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome