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Protein

Alanine racemase 2

Gene

alr2

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Caution

The gene coding for this protein seems to be defective in strain 91001 where it is interrupted by the insertion of an IS285 element.Curated

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase 1 (alr1), Alanine racemase (alr), Alanine racemase (AU253_20065), Alanine racemase 2 (alr2)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei61Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei160SubstrateUniRule annotation1
Active sitei286Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei334Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemase 2UniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr2
Ordered Locus Names:YPO1687, y1849, YP_1816
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001146031 – 394Alanine racemase 2Add BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PaxDbiQ8ZFL4

Interactioni

Protein-protein interaction databases

STRINGi187410.y1849

Structurei

3D structure databases

ProteinModelPortaliQ8ZFL4
SMRiQ8ZFL4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000279190
KOiK01775
OMAiYSDGYRR

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZFL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVACSQPVSK NHLSLTSLSA NAQQPVVNNA WLEISQGALD FNTKKMLTLL
60 70 80 90 100
DNKSTLCAIL KGDAYGHDLT LVTPVMLKNN VQCIGVASNQ ELKTVRDLGF
110 120 130 140 150
TGQLIRVRSA TLKEMQQAMA YDVEELIGDK TVAEQLNNIA KLNGKVLRIH
160 170 180 190 200
LALNSAGMSR NGLEVSKARG LNDAKTIAGL KNLTIVGIMS HYPVEDASEI
210 220 230 240 250
KADLARFQQQ AKDVIAVTGL KREKIKLHVA NTFATLAVPD SWLDMVRVGG
260 270 280 290 300
VFYGDTIAST EYKRVMTFKS NIASLNNYPK GGTVGYDRTY TLKRDSLLAN
310 320 330 340 350
IPVGYADGYR RVFSNAGHVI IQGQRLPVLG KTSMNTVIVD VTDLKKVSLG
360 370 380 390
DEVVLFGKQG NAEIQAEEIE DLSGALFTEM SILWGATNKR ILVD
Length:394
Mass (Da):42,912
Last modified:March 5, 2002 - v1
Checksum:i41516FB5C4EE750F
GO

Sequence cautioni

The sequence AAM85416 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAL20330 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL20330.1 Different initiation.
AE009952 Genomic DNA Translation: AAM85416.1 Different initiation.
AE017042 Genomic DNA No translation available.
PIRiAG0205
RefSeqiYP_002346690.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM85416; AAM85416; y1849
GeneIDi1174524
KEGGiype:YPO1687
ypk:y1849
PATRICifig|214092.21.peg.2032

Similar proteinsi

Entry informationi

Entry nameiALR2_YERPE
AccessioniPrimary (citable) accession number: Q8ZFL4
Secondary accession number(s): Q0WG98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 5, 2002
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health