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Q8ZFL4 (ALR2_YERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alanine racemase 2

EC=5.1.1.1
Gene names
Name:alr2
Ordered Locus Names:YPO1687, y1849, YP_1816
OrganismYersinia pestis [Reference proteome] [HAMAP]
Taxonomic identifier632 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length394 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family.

Caution

The gene coding for this protein seems to be defective in strain 91001 where it is interrupted by the insertion of an IS285 element.

Sequence caution

The sequence AAM85416.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAL20330.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   LigandPyridoxal phosphate
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processD-alanine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionalanine racemase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pyridoxal phosphate binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 394394Alanine racemase 2 HAMAP-Rule MF_01201
PRO_0000114603

Sites

Active site611Proton acceptor; specific for D-alanine By similarity
Active site2861Proton acceptor; specific for L-alanine By similarity
Binding site1601Substrate By similarity
Binding site3341Substrate; via amide nitrogen By similarity

Amino acid modifications

Modified residue611N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8ZFL4 [UniParc].

Last modified March 5, 2002. Version 1.
Checksum: 41516FB5C4EE750F

FASTA39442,912
        10         20         30         40         50         60 
MVACSQPVSK NHLSLTSLSA NAQQPVVNNA WLEISQGALD FNTKKMLTLL DNKSTLCAIL 

        70         80         90        100        110        120 
KGDAYGHDLT LVTPVMLKNN VQCIGVASNQ ELKTVRDLGF TGQLIRVRSA TLKEMQQAMA 

       130        140        150        160        170        180 
YDVEELIGDK TVAEQLNNIA KLNGKVLRIH LALNSAGMSR NGLEVSKARG LNDAKTIAGL 

       190        200        210        220        230        240 
KNLTIVGIMS HYPVEDASEI KADLARFQQQ AKDVIAVTGL KREKIKLHVA NTFATLAVPD 

       250        260        270        280        290        300 
SWLDMVRVGG VFYGDTIAST EYKRVMTFKS NIASLNNYPK GGTVGYDRTY TLKRDSLLAN 

       310        320        330        340        350        360 
IPVGYADGYR RVFSNAGHVI IQGQRLPVLG KTSMNTVIVD VTDLKKVSLG DEVVLFGKQG 

       370        380        390 
NAEIQAEEIE DLSGALFTEM SILWGATNKR ILVD 

« Hide

References

[1]"Genome sequence of Yersinia pestis, the causative agent of plague."
Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. expand/collapse author list , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.
Nature 413:523-527(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CO-92 / Biovar Orientalis.
[2]"Genome sequence of Yersinia pestis KIM."
Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. expand/collapse author list , Matson J.S., Blattner F.R., Perry R.D.
J. Bacteriol. 184:4601-4611(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KIM10+ / Biovar Mediaevalis.
[3]"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. expand/collapse author list , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL590842 Genomic DNA. Translation: CAL20330.1. Different initiation.
AE009952 Genomic DNA. Translation: AAM85416.1. Different initiation.
AE017042 Genomic DNA. No translation available.
PIRAG0205.
RefSeqNP_669165.1. NC_004088.1.
YP_002346690.1. NC_003143.1.

3D structure databases

ProteinModelPortalQ8ZFL4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING214092.YPO1687.

Protocols and materials databases

DNASU1146796.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM85416; AAM85416; y1849.
GeneID1146796.
1174524.
KEGGype:YPO1687.
ypk:y1849.
PATRIC18592836. VBIYerPes7843_2136.

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHOG000279190.
KOK01775.
OMAADLYTVW.
OrthoDBEOG6PP9NJ.
ProtClustDBPRK13340.

Enzyme and pathway databases

BioCycYPES214092:GKDD-1665-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALR2_YERPE
AccessionPrimary (citable) accession number: Q8ZFL4
Secondary accession number(s): Q0WG98
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 5, 2002
Last modified: February 19, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways