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Q8ZFL4

- ALR2_YERPE

UniProt

Q8ZFL4 - ALR2_YERPE

Protein

Alanine racemase 2

Gene

alr2

Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (05 Mar 2002)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei61 – 611Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei160 – 1601SubstrateUniRule annotation
    Active sitei286 – 2861Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei334 – 3341Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciYPES214092:GKDD-1665-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemase 2UniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alr2
    Ordered Locus Names:YPO1687, y1849, YP_1816
    OrganismiYersinia pestis
    Taxonomic identifieri632 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 394394Alanine racemase 2PRO_0000114603Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei61 – 611N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi214092.YPO1687.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8ZFL4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000279190.
    KOiK01775.
    OMAiQQIPCVA.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8ZFL4-1 [UniParc]FASTAAdd to Basket

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    MVACSQPVSK NHLSLTSLSA NAQQPVVNNA WLEISQGALD FNTKKMLTLL    50
    DNKSTLCAIL KGDAYGHDLT LVTPVMLKNN VQCIGVASNQ ELKTVRDLGF 100
    TGQLIRVRSA TLKEMQQAMA YDVEELIGDK TVAEQLNNIA KLNGKVLRIH 150
    LALNSAGMSR NGLEVSKARG LNDAKTIAGL KNLTIVGIMS HYPVEDASEI 200
    KADLARFQQQ AKDVIAVTGL KREKIKLHVA NTFATLAVPD SWLDMVRVGG 250
    VFYGDTIAST EYKRVMTFKS NIASLNNYPK GGTVGYDRTY TLKRDSLLAN 300
    IPVGYADGYR RVFSNAGHVI IQGQRLPVLG KTSMNTVIVD VTDLKKVSLG 350
    DEVVLFGKQG NAEIQAEEIE DLSGALFTEM SILWGATNKR ILVD 394
    Length:394
    Mass (Da):42,912
    Last modified:March 5, 2002 - v1
    Checksum:i41516FB5C4EE750F
    GO

    Sequence cautioni

    The sequence AAM85416.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAL20330.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL20330.1. Different initiation.
    AE009952 Genomic DNA. Translation: AAM85416.1. Different initiation.
    AE017042 Genomic DNA. No translation available.
    PIRiAG0205.
    RefSeqiNP_669165.1. NC_004088.1.
    YP_002346690.1. NC_003143.1.

    Genome annotation databases

    EnsemblBacteriaiAAM85416; AAM85416; y1849.
    GeneIDi1146796.
    1174524.
    KEGGiype:YPO1687.
    ypk:y1849.
    PATRICi18592836. VBIYerPes7843_2136.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL20330.1 . Different initiation.
    AE009952 Genomic DNA. Translation: AAM85416.1 . Different initiation.
    AE017042 Genomic DNA. No translation available.
    PIRi AG0205.
    RefSeqi NP_669165.1. NC_004088.1.
    YP_002346690.1. NC_003143.1.

    3D structure databases

    ProteinModelPortali Q8ZFL4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 214092.YPO1687.

    Protocols and materials databases

    DNASUi 1146796.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM85416 ; AAM85416 ; y1849 .
    GeneIDi 1146796.
    1174524.
    KEGGi ype:YPO1687.
    ypk:y1849.
    PATRICi 18592836. VBIYerPes7843_2136.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000279190.
    KOi K01775.
    OMAi QQIPCVA.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci YPES214092:GKDD-1665-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CO-92 / Biovar Orientalis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIM10+ / Biovar Mediaevalis.
    3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
      Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
      , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
      DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 91001 / Biovar Mediaevalis.

    Entry informationi

    Entry nameiALR2_YERPE
    AccessioniPrimary (citable) accession number: Q8ZFL4
    Secondary accession number(s): Q0WG98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 5, 2002
    Last sequence update: March 5, 2002
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    The gene coding for this protein seems to be defective in strain 91001 where it is interrupted by the insertion of an IS285 element.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3