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Q8ZFL4

- ALR2_YERPE

UniProt

Q8ZFL4 - ALR2_YERPE

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Protein
Alanine racemase 2
Gene
alr2, YPO1687, y1849, YP_1816
Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei61 – 611Proton acceptor; specific for D-alanine By similarity
Binding sitei160 – 1601Substrate By similarity
Active sitei286 – 2861Proton acceptor; specific for L-alanine By similarity
Binding sitei334 – 3341Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciYPES214092:GKDD-1665-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemase 2 (EC:5.1.1.1)
Gene namesi
Name:alr2
Ordered Locus Names:YPO1687, y1849, YP_1816
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Alanine racemase 2UniRule annotation
PRO_0000114603Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi214092.YPO1687.

Structurei

3D structure databases

ProteinModelPortaliQ8ZFL4.

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000279190.
KOiK01775.
OMAiQQIPCVA.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZFL4-1 [UniParc]FASTAAdd to Basket

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MVACSQPVSK NHLSLTSLSA NAQQPVVNNA WLEISQGALD FNTKKMLTLL    50
DNKSTLCAIL KGDAYGHDLT LVTPVMLKNN VQCIGVASNQ ELKTVRDLGF 100
TGQLIRVRSA TLKEMQQAMA YDVEELIGDK TVAEQLNNIA KLNGKVLRIH 150
LALNSAGMSR NGLEVSKARG LNDAKTIAGL KNLTIVGIMS HYPVEDASEI 200
KADLARFQQQ AKDVIAVTGL KREKIKLHVA NTFATLAVPD SWLDMVRVGG 250
VFYGDTIAST EYKRVMTFKS NIASLNNYPK GGTVGYDRTY TLKRDSLLAN 300
IPVGYADGYR RVFSNAGHVI IQGQRLPVLG KTSMNTVIVD VTDLKKVSLG 350
DEVVLFGKQG NAEIQAEEIE DLSGALFTEM SILWGATNKR ILVD 394
Length:394
Mass (Da):42,912
Last modified:March 5, 2002 - v1
Checksum:i41516FB5C4EE750F
GO

Sequence cautioni

The sequence AAM85416.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAL20330.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL20330.1. Different initiation.
AE009952 Genomic DNA. Translation: AAM85416.1. Different initiation.
AE017042 Genomic DNA. No translation available.
PIRiAG0205.
RefSeqiNP_669165.1. NC_004088.1.
YP_002346690.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM85416; AAM85416; y1849.
GeneIDi1146796.
1174524.
KEGGiype:YPO1687.
ypk:y1849.
PATRICi18592836. VBIYerPes7843_2136.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL20330.1 . Different initiation.
AE009952 Genomic DNA. Translation: AAM85416.1 . Different initiation.
AE017042 Genomic DNA. No translation available.
PIRi AG0205.
RefSeqi NP_669165.1. NC_004088.1.
YP_002346690.1. NC_003143.1.

3D structure databases

ProteinModelPortali Q8ZFL4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 214092.YPO1687.

Protocols and materials databases

DNASUi 1146796.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM85416 ; AAM85416 ; y1849 .
GeneIDi 1146796.
1174524.
KEGGi ype:YPO1687.
ypk:y1849.
PATRICi 18592836. VBIYerPes7843_2136.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000279190.
KOi K01775.
OMAi QQIPCVA.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci YPES214092:GKDD-1665-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiALR2_YERPE
AccessioniPrimary (citable) accession number: Q8ZFL4
Secondary accession number(s): Q0WG98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 5, 2002
Last modified: June 11, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

The gene coding for this protein seems to be defective in strain 91001 where it is interrupted by the insertion of an IS285 element.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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