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Protein

Alanine racemase 2

Gene

alr2

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathway: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase 1 (alr1), Alanine racemase 2 (alr2)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei61 – 611Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei160 – 1601SubstrateUniRule annotation
Active sitei286 – 2861Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei334 – 3341Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciYPES214092:GKDD-1665-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemase 2UniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr2
Ordered Locus Names:YPO1687, y1849, YP_1816
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815 Componenti: Chromosome UP000002490 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Alanine racemase 2PRO_0000114603Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi214092.YPO1687.

Structurei

3D structure databases

ProteinModelPortaliQ8ZFL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000279190.
KOiK01775.
OMAiNTVMVDV.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZFL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVACSQPVSK NHLSLTSLSA NAQQPVVNNA WLEISQGALD FNTKKMLTLL
60 70 80 90 100
DNKSTLCAIL KGDAYGHDLT LVTPVMLKNN VQCIGVASNQ ELKTVRDLGF
110 120 130 140 150
TGQLIRVRSA TLKEMQQAMA YDVEELIGDK TVAEQLNNIA KLNGKVLRIH
160 170 180 190 200
LALNSAGMSR NGLEVSKARG LNDAKTIAGL KNLTIVGIMS HYPVEDASEI
210 220 230 240 250
KADLARFQQQ AKDVIAVTGL KREKIKLHVA NTFATLAVPD SWLDMVRVGG
260 270 280 290 300
VFYGDTIAST EYKRVMTFKS NIASLNNYPK GGTVGYDRTY TLKRDSLLAN
310 320 330 340 350
IPVGYADGYR RVFSNAGHVI IQGQRLPVLG KTSMNTVIVD VTDLKKVSLG
360 370 380 390
DEVVLFGKQG NAEIQAEEIE DLSGALFTEM SILWGATNKR ILVD
Length:394
Mass (Da):42,912
Last modified:March 5, 2002 - v1
Checksum:i41516FB5C4EE750F
GO

Sequence cautioni

The sequence AAM85416.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAL20330.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL20330.1. Different initiation.
AE009952 Genomic DNA. Translation: AAM85416.1. Different initiation.
AE017042 Genomic DNA. No translation available.
PIRiAG0205.
RefSeqiNP_669165.1. NC_004088.1.
YP_002346690.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM85416; AAM85416; y1849.
GeneIDi1174524.
KEGGiype:YPO1687.
ypk:y1849.
PATRICi18592836. VBIYerPes7843_2136.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL20330.1. Different initiation.
AE009952 Genomic DNA. Translation: AAM85416.1. Different initiation.
AE017042 Genomic DNA. No translation available.
PIRiAG0205.
RefSeqiNP_669165.1. NC_004088.1.
YP_002346690.1. NC_003143.1.

3D structure databases

ProteinModelPortaliQ8ZFL4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi214092.YPO1687.

Protocols and materials databases

DNASUi1146796.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM85416; AAM85416; y1849.
GeneIDi1174524.
KEGGiype:YPO1687.
ypk:y1849.
PATRICi18592836. VBIYerPes7843_2136.

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000279190.
KOiK01775.
OMAiNTVMVDV.
OrthoDBiEOG6PP9NJ.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciYPES214092:GKDD-1665-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiALR2_YERPE
AccessioniPrimary (citable) accession number: Q8ZFL4
Secondary accession number(s): Q0WG98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 5, 2002
Last modified: June 24, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

The gene coding for this protein seems to be defective in strain 91001 where it is interrupted by the insertion of an IS285 element.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.