ID DCYD_YERPE Reviewed; 330 AA. AC Q8ZF73; Q0WFU9; DT 22-FEB-2003, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2002, sequence version 1. DT 27-MAR-2024, entry version 133. DE RecName: Full=D-cysteine desulfhydrase {ECO:0000255|HAMAP-Rule:MF_01045}; DE EC=4.4.1.15 {ECO:0000255|HAMAP-Rule:MF_01045}; GN Name=dcyD {ECO:0000255|HAMAP-Rule:MF_01045}; Synonyms=acd; GN OrderedLocusNames=YPO1845, y2462, YP_1548; OS Yersinia pestis. OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Yersiniaceae; Yersinia. OX NCBI_TaxID=632; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CO-92 / Biovar Orientalis; RX PubMed=11586360; DOI=10.1038/35097083; RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T., RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., RA Stevens K., Whitehead S., Barrell B.G.; RT "Genome sequence of Yersinia pestis, the causative agent of plague."; RL Nature 413:523-527(2001). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KIM10+ / Biovar Mediaevalis; RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002; RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.; RT "Genome sequence of Yersinia pestis KIM."; RL J. Bacteriol. 184:4601-4611(2002). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=91001 / Biovar Mediaevalis; RX PubMed=15368893; DOI=10.1093/dnares/11.3.179; RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., RA Wang J., Huang P., Yang R.; RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate RT avirulent to humans."; RL DNA Res. 11:179-197(2004). CC -!- FUNCTION: Catalyzes the alpha,beta-elimination reaction of D-cysteine CC and of several D-cysteine derivatives. It could be a defense mechanism CC against D-cysteine. {ECO:0000255|HAMAP-Rule:MF_01045}. CC -!- CATALYTIC ACTIVITY: CC Reaction=D-cysteine + H2O = H(+) + hydrogen sulfide + NH4(+) + CC pyruvate; Xref=Rhea:RHEA:11268, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:29919, CC ChEBI:CHEBI:35236; EC=4.4.1.15; Evidence={ECO:0000255|HAMAP- CC Rule:MF_01045}; CC -!- COFACTOR: CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; CC Evidence={ECO:0000255|HAMAP-Rule:MF_01045}; CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01045}. CC -!- SIMILARITY: Belongs to the ACC deaminase/D-cysteine desulfhydrase CC family. {ECO:0000255|HAMAP-Rule:MF_01045}. CC -!- SEQUENCE CAUTION: CC Sequence=AAM86019.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL590842; CAL20485.1; -; Genomic_DNA. DR EMBL; AE009952; AAM86019.1; ALT_INIT; Genomic_DNA. DR EMBL; AE017042; AAS61783.1; -; Genomic_DNA. DR PIR; AB0225; AB0225. DR RefSeq; WP_002227959.1; NZ_WUCL01000007.1. DR RefSeq; YP_002346839.1; NC_003143.1. DR AlphaFoldDB; Q8ZF73; -. DR SMR; Q8ZF73; -. DR STRING; 214092.YPO1845; -. DR PaxDb; 214092-YPO1845; -. DR EnsemblBacteria; AAS61783; AAS61783; YP_1548. DR GeneID; 57976736; -. DR KEGG; ype:YPO1845; -. DR KEGG; ypk:y2462; -. DR KEGG; ypm:YP_1548; -. DR PATRIC; fig|214092.21.peg.2207; -. DR eggNOG; COG2515; Bacteria. DR HOGENOM; CLU_048897_1_0_6; -. DR OMA; GIQSNHA; -. DR OrthoDB; 9801249at2; -. DR Proteomes; UP000000815; Chromosome. DR Proteomes; UP000001019; Chromosome. DR Proteomes; UP000002490; Chromosome. DR GO; GO:0019148; F:D-cysteine desulfhydrase activity; IBA:GO_Central. DR GO; GO:0046416; P:D-amino acid metabolic process; IEA:UniProtKB-UniRule. DR CDD; cd06449; ACCD; 1. DR Gene3D; 3.40.50.1100; -; 2. DR HAMAP; MF_01045; D_Cys_desulfhydr; 1. DR InterPro; IPR027278; ACCD_DCysDesulf. DR InterPro; IPR005966; D-Cys_desShydrase. DR InterPro; IPR023702; D_Cys_desulphydr_bac. DR InterPro; IPR001926; TrpB-like_PALP. DR InterPro; IPR036052; TrpB-like_PALP_sf. DR NCBIfam; TIGR01275; ACC_deam_rel; 1. DR PANTHER; PTHR43780; 1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED; 1. DR PANTHER; PTHR43780:SF2; 1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED; 1. DR Pfam; PF00291; PALP; 1. DR PIRSF; PIRSF006278; ACCD_DCysDesulf; 1. DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1. PE 3: Inferred from homology; KW Lyase; Pyridoxal phosphate; Reference proteome. FT CHAIN 1..330 FT /note="D-cysteine desulfhydrase" FT /id="PRO_0000184519" FT MOD_RES 52 FT /note="N6-(pyridoxal phosphate)lysine" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01045" SQ SEQUENCE 330 AA; 35039 MW; CDC974B8DBF26922 CRC64; MTLQQKLTQF PRLDLVGNAT PLEKLSRLSD YLGREIYIKR DDVTPVALGG NKLRKLEFLA ADALRQGADT LVTAGAIQSN HVRQTAAVAA KLGLHCVALL ENPIGTEQAN YLTNGNRLLL DLFNVDVVMC EALNDPNQQL AELATRVEAQ GFRPYVVPIG GSNALGALGY VQCSLEIAAQ AAGNVAFSSV VVASGSAGTH AGLAVGLQQL LPDAELIGVT VSRSADEQRP KVAQIQQALA TSLGMTDPLA KITLWDSYFA PQYGMPNEEG IAAIKLLARL EGILLDPVYT GKAMAGLLDG IEQQKFCDKG PILFIHTGGA PALFAYHPQV //