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Protein

D-cysteine desulfhydrase

Gene

dcyD

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine.UniRule annotation

Catalytic activityi

D-cysteine + H2O = H2S + NH3 + pyruvate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionLyase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
D-cysteine desulfhydraseUniRule annotation (EC:4.4.1.15UniRule annotation)
Gene namesi
Name:dcyDUniRule annotation
Synonyms:acd
Ordered Locus Names:YPO1845, y2462, YP_1548
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001845191 – 330D-cysteine desulfhydraseAdd BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PaxDbiQ8ZF73
PRIDEiQ8ZF73

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi187410.y2462

Structurei

3D structure databases

ProteinModelPortaliQ8ZF73
SMRiQ8ZF73
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ACC deaminase/D-cysteine desulfhydrase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105K6H Bacteria
COG2515 LUCA
HOGENOMiHOG000022459
KOiK05396
OMAiAKIGMKC

Family and domain databases

HAMAPiMF_01045 D_Cys_desulfhydr, 1 hit
InterProiView protein in InterPro
IPR027278 ACCD_DCysDesulf
IPR005966 D-Cys_desShydrase
IPR023702 D_Cys_desulphydr_bac
IPR001926 PLP-dep
IPR036052 Trypto_synt_PLP_dependent
PfamiView protein in Pfam
PF00291 PALP, 1 hit
PIRSFiPIRSF006278 ACCD_DCysDesulf, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR01275 ACC_deam_rel, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZF73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLQQKLTQF PRLDLVGNAT PLEKLSRLSD YLGREIYIKR DDVTPVALGG
60 70 80 90 100
NKLRKLEFLA ADALRQGADT LVTAGAIQSN HVRQTAAVAA KLGLHCVALL
110 120 130 140 150
ENPIGTEQAN YLTNGNRLLL DLFNVDVVMC EALNDPNQQL AELATRVEAQ
160 170 180 190 200
GFRPYVVPIG GSNALGALGY VQCSLEIAAQ AAGNVAFSSV VVASGSAGTH
210 220 230 240 250
AGLAVGLQQL LPDAELIGVT VSRSADEQRP KVAQIQQALA TSLGMTDPLA
260 270 280 290 300
KITLWDSYFA PQYGMPNEEG IAAIKLLARL EGILLDPVYT GKAMAGLLDG
310 320 330
IEQQKFCDKG PILFIHTGGA PALFAYHPQV
Length:330
Mass (Da):35,039
Last modified:March 1, 2002 - v1
Checksum:iCDC974B8DBF26922
GO

Sequence cautioni

The sequence AAM86019 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL20485.1
AE009952 Genomic DNA Translation: AAM86019.1 Different initiation.
AE017042 Genomic DNA Translation: AAS61783.1
PIRiAB0225
RefSeqiWP_002227959.1, NZ_PDBR01000007.1
YP_002346839.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM86019; AAM86019; y2462
AAS61783; AAS61783; YP_1548
GeneIDi1174680
KEGGiype:YPO1845
ypk:y2462
ypm:YP_1548
PATRICifig|214092.21.peg.2207

Similar proteinsi

Entry informationi

Entry nameiDCYD_YERPE
AccessioniPrimary (citable) accession number: Q8ZF73
Secondary accession number(s): Q0WFU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2003
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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