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Q8ZF73

- DCYD_YERPE

UniProt

Q8ZF73 - DCYD_YERPE

Protein

D-cysteine desulfhydrase

Gene

dcyD

Organism
Yersinia pestis
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine.UniRule annotation

    Catalytic activityi

    D-cysteine + H2O = H2S + NH3 + pyruvate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. D-cysteine desulfhydrase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-amino acid metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciYPES214092:GKDD-1819-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D-cysteine desulfhydraseUniRule annotation (EC:4.4.1.15UniRule annotation)
    Gene namesi
    Name:dcyDUniRule annotation
    Synonyms:acd
    Ordered Locus Names:YPO1845, y2462, YP_1548
    OrganismiYersinia pestis
    Taxonomic identifieri632 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 330330D-cysteine desulfhydrasePRO_0000184519Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei52 – 521N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiQ8ZF73.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi214092.YPO1845.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8ZF73.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ACC deaminase/D-cysteine desulfhydrase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2515.
    HOGENOMiHOG000022459.
    KOiK05396.
    OMAiIMAQSFE.
    OrthoDBiEOG6FBX0P.

    Family and domain databases

    HAMAPiMF_01045. D_Cys_desulfhydr.
    InterProiIPR027278. ACCD_DCysDesulf.
    IPR005966. D-Cys_desShydrase.
    IPR023702. D_Cys_desulphydr_bac.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view]
    PfamiPF00291. PALP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006278. ACCD_DCysDesulf. 1 hit.
    SUPFAMiSSF53686. SSF53686. 1 hit.
    TIGRFAMsiTIGR01275. ACC_deam_rel. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8ZF73-1 [UniParc]FASTAAdd to Basket

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    MTLQQKLTQF PRLDLVGNAT PLEKLSRLSD YLGREIYIKR DDVTPVALGG    50
    NKLRKLEFLA ADALRQGADT LVTAGAIQSN HVRQTAAVAA KLGLHCVALL 100
    ENPIGTEQAN YLTNGNRLLL DLFNVDVVMC EALNDPNQQL AELATRVEAQ 150
    GFRPYVVPIG GSNALGALGY VQCSLEIAAQ AAGNVAFSSV VVASGSAGTH 200
    AGLAVGLQQL LPDAELIGVT VSRSADEQRP KVAQIQQALA TSLGMTDPLA 250
    KITLWDSYFA PQYGMPNEEG IAAIKLLARL EGILLDPVYT GKAMAGLLDG 300
    IEQQKFCDKG PILFIHTGGA PALFAYHPQV 330
    Length:330
    Mass (Da):35,039
    Last modified:March 1, 2002 - v1
    Checksum:iCDC974B8DBF26922
    GO

    Sequence cautioni

    The sequence AAM86019.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL20485.1.
    AE009952 Genomic DNA. Translation: AAM86019.1. Different initiation.
    AE017042 Genomic DNA. Translation: AAS61783.1.
    PIRiAB0225.
    RefSeqiNP_992906.1. NC_005810.1.
    YP_002346839.1. NC_003143.1.

    Genome annotation databases

    EnsemblBacteriaiAAM86019; AAM86019; y2462.
    AAS61783; AAS61783; YP_1548.
    GeneIDi1174680.
    2764100.
    KEGGiype:YPO1845.
    ypm:YP_1548.
    PATRICi18593206. VBIYerPes7843_2320.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL20485.1 .
    AE009952 Genomic DNA. Translation: AAM86019.1 . Different initiation.
    AE017042 Genomic DNA. Translation: AAS61783.1 .
    PIRi AB0225.
    RefSeqi NP_992906.1. NC_005810.1.
    YP_002346839.1. NC_003143.1.

    3D structure databases

    ProteinModelPortali Q8ZF73.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 214092.YPO1845.

    Proteomic databases

    PRIDEi Q8ZF73.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM86019 ; AAM86019 ; y2462 .
    AAS61783 ; AAS61783 ; YP_1548 .
    GeneIDi 1174680.
    2764100.
    KEGGi ype:YPO1845.
    ypm:YP_1548.
    PATRICi 18593206. VBIYerPes7843_2320.

    Phylogenomic databases

    eggNOGi COG2515.
    HOGENOMi HOG000022459.
    KOi K05396.
    OMAi IMAQSFE.
    OrthoDBi EOG6FBX0P.

    Enzyme and pathway databases

    BioCyci YPES214092:GKDD-1819-MONOMER.

    Family and domain databases

    HAMAPi MF_01045. D_Cys_desulfhydr.
    InterProi IPR027278. ACCD_DCysDesulf.
    IPR005966. D-Cys_desShydrase.
    IPR023702. D_Cys_desulphydr_bac.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view ]
    Pfami PF00291. PALP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006278. ACCD_DCysDesulf. 1 hit.
    SUPFAMi SSF53686. SSF53686. 1 hit.
    TIGRFAMsi TIGR01275. ACC_deam_rel. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CO-92 / Biovar Orientalis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIM10+ / Biovar Mediaevalis.
    3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
      Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
      , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
      DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 91001 / Biovar Mediaevalis.

    Entry informationi

    Entry nameiDCYD_YERPE
    AccessioniPrimary (citable) accession number: Q8ZF73
    Secondary accession number(s): Q0WFU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 22, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3