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Protein

Crossover junction endodeoxyribonuclease RuvC

Gene

ruvC

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8MagnesiumUniRule annotation1
Metal bindingi67MagnesiumUniRule annotation1
Metal bindingi139MagnesiumUniRule annotation1
Metal bindingi142MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Nuclease
Biological processDNA damage, DNA recombination, DNA repair
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RuvCUniRule annotation (EC:3.1.22.4UniRule annotation)
Alternative name(s):
Holliday junction nuclease RuvCUniRule annotation
Holliday junction resolvase RuvCUniRule annotation
Gene namesi
Name:ruvCUniRule annotation
Ordered Locus Names:YPO2056, y2254, YP_1899
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001831541 – 173Crossover junction endodeoxyribonuclease RuvCAdd BLAST173

Proteomic databases

PaxDbiQ8ZEU7

Interactioni

Protein-protein interaction databases

STRINGi187410.y2254

Structurei

3D structure databases

ProteinModelPortaliQ8ZEU7
SMRiQ8ZEU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105NHU Bacteria
COG0817 LUCA
HOGENOMiHOG000012181
KOiK01159
OMAiGLTRCGI

Family and domain databases

Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00034 RuvC, 1 hit
InterProiView protein in InterPro
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR020563 X-over_junc_endoDNase_Mg_BS
IPR002176 X-over_junc_endoDNase_RuvC
PANTHERiPTHR30194 PTHR30194, 1 hit
PfamiView protein in Pfam
PF02075 RuvC, 1 hit
PRINTSiPR00696 RSOLVASERUVC
SUPFAMiSSF53098 SSF53098, 1 hit
TIGRFAMsiTIGR00228 ruvC, 1 hit
PROSITEiView protein in PROSITE
PS01321 RUVC, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZEU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIVLGIDPG SRVTGYGVIR QQGRQLTYLG SGCIRTVVDD MPTRLKLIYA
60 70 80 90 100
GVTEIITQFQ PDFFAIEQVF MAKNPDSALK LGQARGAAIV AAVNLNLPVS
110 120 130 140 150
EYAARQVKQT VVGTGAAEKS QVQHMVRSLL KLPANPQADA ADALAIAITH
160 170
CHLSQNTLRL GNDQMTLSRG RIR
Length:173
Mass (Da):18,641
Last modified:March 1, 2002 - v1
Checksum:i946C0499BFA4EFE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL20691.1
AE009952 Genomic DNA Translation: AAM85814.1
AE017042 Genomic DNA Translation: AAS62117.1
PIRiAH0250
RefSeqiWP_002211201.1, NZ_PDBR01000024.1
YP_002347038.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM85814; AAM85814; y2254
AAS62117; AAS62117; YP_1899
GeneIDi1174894
KEGGiype:YPO2056
ypj:CH55_680
ypk:y2254
ypl:CH46_3055
ypm:YP_1899
ypv:BZ15_1481
ypw:CH59_4067
PATRICifig|214092.21.peg.2443

Similar proteinsi

Entry informationi

Entry nameiRUVC_YERPE
AccessioniPrimary (citable) accession number: Q8ZEU7
Secondary accession number(s): Q0WFA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health