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Q8ZES9

- LCFA_YERPE

UniProt

Q8ZES9 - LCFA_YERPE

Protein

Long-chain-fatty-acid--CoA ligase

Gene

fadD

Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids.By similarity

    Catalytic activityi

    ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi213 – 22412ATPCuratedAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYPES214092:GKDD-2049-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long-chain-fatty-acid--CoA ligase (EC:6.2.1.3)
    Alternative name(s):
    Long-chain acyl-CoA synthetase
    Gene namesi
    Name:fadD
    Ordered Locus Names:YPO2074, y2236, YP_1917
    OrganismiYersinia pestis
    Taxonomic identifieri632 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

    Subcellular locationi

    Membrane Curated; Peripheral membrane protein Curated
    Note: Partially membrane-associated.Curated

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 562562Long-chain-fatty-acid--CoA ligasePRO_0000193130Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.Curated

    Protein-protein interaction databases

    STRINGi214092.YPO2074.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8ZES9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0318.
    HOGENOMiHOG000229983.
    KOiK01897.
    OMAiACIANTP.
    OrthoDBiEOG6MH5BV.

    Family and domain databases

    InterProiIPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8ZES9-1 [UniParc]FASTAAdd to Basket

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    MEKVWLKRYP ADVPAEIDPD RYSSLIEMFE NAALRYADQP AFINMGEVMT    50
    FRKLEERSRA FAAYLQQGLG LQKGDRVALM MPNLLQYPIA LFGVLRAGMI 100
    VVNVNPLYTP RELEHQLSDS GAVAIVIVSN FAHTLEKVVF KTQVRHVILT 150
    RMGDQLSAAK GTLVNFVVKY IKRLVPKYYL PDAISFRTVL QKGRRMQYVK 200
    PDVINTDTAF LQYTGGTTGV AKGAILTHRN MQSNLEQAKA AYAPLLQPGR 250
    DLVVTALPLY HIFALTVNCL LFIELGGRSL LITNPRDIPG MVKELSRYPF 300
    TAITGVNTLF NALLNNEEFT HLDFSTLRLS VGGGMPVQKA VAEKWETLTG 350
    KHLLEGYGLT ECSPLVTGNP YDLKHYSGSI GLPVPSTDVR LRDDDGNDVE 400
    LGKPGELWVR GPQVMLGYWQ RPDATDDVLK DGWLATGDIA TMDEDGFLRI 450
    VDRKKDMILV SGFNVYPNEI EEVVALHAKV LESAVIGVPN EVSGEAVKVF 500
    VVKNDASLTP EELLTHCRRY LTGYKVPKIV EFRDELPKSN VGKILRRELR 550
    DEEVKVGTTD AA 562
    Length:562
    Mass (Da):62,639
    Last modified:March 1, 2002 - v1
    Checksum:i812A872B3713D3FD
    GO

    Sequence cautioni

    The sequence AAM85796.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAS62135.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti504 – 5041N → K in strain: KIM5 and 91001.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL20709.1.
    AE009952 Genomic DNA. Translation: AAM85796.1. Different initiation.
    AE017042 Genomic DNA. Translation: AAS62135.1. Different initiation.
    PIRiAB0253.
    RefSeqiNP_669545.1. NC_004088.1.
    NP_993258.1. NC_005810.1.
    YP_002347056.1. NC_003143.1.

    Genome annotation databases

    EnsemblBacteriaiAAM85796; AAM85796; y2236.
    AAS62135; AAS62135; YP_1917.
    GeneIDi1147183.
    1174912.
    2766250.
    KEGGiype:YPO2074.
    ypk:y2236.
    ypm:YP_1917.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL20709.1 .
    AE009952 Genomic DNA. Translation: AAM85796.1 . Different initiation.
    AE017042 Genomic DNA. Translation: AAS62135.1 . Different initiation.
    PIRi AB0253.
    RefSeqi NP_669545.1. NC_004088.1.
    NP_993258.1. NC_005810.1.
    YP_002347056.1. NC_003143.1.

    3D structure databases

    ProteinModelPortali Q8ZES9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 214092.YPO2074.

    Protocols and materials databases

    DNASUi 1147183.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM85796 ; AAM85796 ; y2236 .
    AAS62135 ; AAS62135 ; YP_1917 .
    GeneIDi 1147183.
    1174912.
    2766250.
    KEGGi ype:YPO2074.
    ypk:y2236.
    ypm:YP_1917.

    Phylogenomic databases

    eggNOGi COG0318.
    HOGENOMi HOG000229983.
    KOi K01897.
    OMAi ACIANTP.
    OrthoDBi EOG6MH5BV.

    Enzyme and pathway databases

    BioCyci YPES214092:GKDD-2049-MONOMER.

    Family and domain databases

    InterProi IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CO-92 / Biovar Orientalis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIM10+ / Biovar Mediaevalis.
    3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
      Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
      , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
      DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 91001 / Biovar Mediaevalis.

    Entry informationi

    Entry nameiLCFA_YERPE
    AccessioniPrimary (citable) accession number: Q8ZES9
    Secondary accession number(s): Q0WF82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3