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Q8ZES9

- LCFA_YERPE

UniProt

Q8ZES9 - LCFA_YERPE

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Protein

Long-chain-fatty-acid--CoA ligase

Gene

fadD

Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids.By similarity

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi213 – 22412ATPCuratedAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYPES214092:GKDD-2049-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase (EC:6.2.1.3)
Alternative name(s):
Long-chain acyl-CoA synthetase
Gene namesi
Name:fadD
Ordered Locus Names:YPO2074, y2236, YP_1917
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

Subcellular locationi

Membrane Curated; Peripheral membrane protein Curated
Note: Partially membrane-associated.Curated

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Long-chain-fatty-acid--CoA ligasePRO_0000193130Add
BLAST

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi214092.YPO2074.

Structurei

3D structure databases

ProteinModelPortaliQ8ZES9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0318.
HOGENOMiHOG000229983.
KOiK01897.
OMAiACIANTP.
OrthoDBiEOG6MH5BV.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZES9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKVWLKRYP ADVPAEIDPD RYSSLIEMFE NAALRYADQP AFINMGEVMT
60 70 80 90 100
FRKLEERSRA FAAYLQQGLG LQKGDRVALM MPNLLQYPIA LFGVLRAGMI
110 120 130 140 150
VVNVNPLYTP RELEHQLSDS GAVAIVIVSN FAHTLEKVVF KTQVRHVILT
160 170 180 190 200
RMGDQLSAAK GTLVNFVVKY IKRLVPKYYL PDAISFRTVL QKGRRMQYVK
210 220 230 240 250
PDVINTDTAF LQYTGGTTGV AKGAILTHRN MQSNLEQAKA AYAPLLQPGR
260 270 280 290 300
DLVVTALPLY HIFALTVNCL LFIELGGRSL LITNPRDIPG MVKELSRYPF
310 320 330 340 350
TAITGVNTLF NALLNNEEFT HLDFSTLRLS VGGGMPVQKA VAEKWETLTG
360 370 380 390 400
KHLLEGYGLT ECSPLVTGNP YDLKHYSGSI GLPVPSTDVR LRDDDGNDVE
410 420 430 440 450
LGKPGELWVR GPQVMLGYWQ RPDATDDVLK DGWLATGDIA TMDEDGFLRI
460 470 480 490 500
VDRKKDMILV SGFNVYPNEI EEVVALHAKV LESAVIGVPN EVSGEAVKVF
510 520 530 540 550
VVKNDASLTP EELLTHCRRY LTGYKVPKIV EFRDELPKSN VGKILRRELR
560
DEEVKVGTTD AA
Length:562
Mass (Da):62,639
Last modified:March 1, 2002 - v1
Checksum:i812A872B3713D3FD
GO

Sequence cautioni

The sequence AAM85796.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAS62135.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti504 – 5041N → K in strain: KIM5 and 91001.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL20709.1.
AE009952 Genomic DNA. Translation: AAM85796.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS62135.1. Different initiation.
PIRiAB0253.
RefSeqiNP_669545.1. NC_004088.1.
NP_993258.1. NC_005810.1.
YP_002347056.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM85796; AAM85796; y2236.
AAS62135; AAS62135; YP_1917.
GeneIDi1147183.
1174912.
2766250.
KEGGiype:YPO2074.
ypk:y2236.
ypm:YP_1917.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL20709.1 .
AE009952 Genomic DNA. Translation: AAM85796.1 . Different initiation.
AE017042 Genomic DNA. Translation: AAS62135.1 . Different initiation.
PIRi AB0253.
RefSeqi NP_669545.1. NC_004088.1.
NP_993258.1. NC_005810.1.
YP_002347056.1. NC_003143.1.

3D structure databases

ProteinModelPortali Q8ZES9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 214092.YPO2074.

Protocols and materials databases

DNASUi 1147183.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM85796 ; AAM85796 ; y2236 .
AAS62135 ; AAS62135 ; YP_1917 .
GeneIDi 1147183.
1174912.
2766250.
KEGGi ype:YPO2074.
ypk:y2236.
ypm:YP_1917.

Phylogenomic databases

eggNOGi COG0318.
HOGENOMi HOG000229983.
KOi K01897.
OMAi ACIANTP.
OrthoDBi EOG6MH5BV.

Enzyme and pathway databases

BioCyci YPES214092:GKDD-2049-MONOMER.

Family and domain databases

InterProi IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiLCFA_YERPE
AccessioniPrimary (citable) accession number: Q8ZES9
Secondary accession number(s): Q0WF82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3