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Protein

Long-chain-fatty-acid--CoA ligase

Gene

fadD

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids.By similarity

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi213 – 224ATPCuratedAdd BLAST12

GO - Molecular functioni

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase (EC:6.2.1.3)
Alternative name(s):
Long-chain acyl-CoA synthetase
Gene namesi
Name:fadD
Ordered Locus Names:YPO2074, y2236, YP_1917
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001931301 – 562Long-chain-fatty-acid--CoA ligaseAdd BLAST562

Proteomic databases

PaxDbiQ8ZES9

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi187410.y2236

Structurei

3D structure databases

ProteinModelPortaliQ8ZES9
SMRiQ8ZES9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CEY Bacteria
COG0318 LUCA
HOGENOMiHOG000229983
KOiK01897
OMAiKTQVKHV

Family and domain databases

InterProiView protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZES9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKVWLKRYP ADVPAEIDPD RYSSLIEMFE NAALRYADQP AFINMGEVMT
60 70 80 90 100
FRKLEERSRA FAAYLQQGLG LQKGDRVALM MPNLLQYPIA LFGVLRAGMI
110 120 130 140 150
VVNVNPLYTP RELEHQLSDS GAVAIVIVSN FAHTLEKVVF KTQVRHVILT
160 170 180 190 200
RMGDQLSAAK GTLVNFVVKY IKRLVPKYYL PDAISFRTVL QKGRRMQYVK
210 220 230 240 250
PDVINTDTAF LQYTGGTTGV AKGAILTHRN MQSNLEQAKA AYAPLLQPGR
260 270 280 290 300
DLVVTALPLY HIFALTVNCL LFIELGGRSL LITNPRDIPG MVKELSRYPF
310 320 330 340 350
TAITGVNTLF NALLNNEEFT HLDFSTLRLS VGGGMPVQKA VAEKWETLTG
360 370 380 390 400
KHLLEGYGLT ECSPLVTGNP YDLKHYSGSI GLPVPSTDVR LRDDDGNDVE
410 420 430 440 450
LGKPGELWVR GPQVMLGYWQ RPDATDDVLK DGWLATGDIA TMDEDGFLRI
460 470 480 490 500
VDRKKDMILV SGFNVYPNEI EEVVALHAKV LESAVIGVPN EVSGEAVKVF
510 520 530 540 550
VVKNDASLTP EELLTHCRRY LTGYKVPKIV EFRDELPKSN VGKILRRELR
560
DEEVKVGTTD AA
Length:562
Mass (Da):62,639
Last modified:March 1, 2002 - v1
Checksum:i812A872B3713D3FD
GO

Sequence cautioni

The sequence AAM85796 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAS62135 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti504N → K in strain: KIM5 and 91001. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL20709.1
AE009952 Genomic DNA Translation: AAM85796.1 Different initiation.
AE017042 Genomic DNA Translation: AAS62135.1 Different initiation.
PIRiAB0253
RefSeqiWP_002211182.1, NZ_LIXY01000014.1
YP_002347056.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM85796; AAM85796; y2236
AAS62135; AAS62135; YP_1917
GeneIDi1174912
KEGGiype:YPO2074
ypk:y2236
ypl:CH46_3036
ypm:YP_1917
ypv:BZ15_1462
ypw:CH59_4048
PATRICifig|1028802.3.peg.2

Similar proteinsi

Entry informationi

Entry nameiLCFA_YERPE
AccessioniPrimary (citable) accession number: Q8ZES9
Secondary accession number(s): Q0WF82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 1, 2002
Last modified: June 20, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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