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Protein

Thymidine kinase

Gene

tdk

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88Proton acceptorUniRule annotation1
Metal bindingi145ZincUniRule annotation1
Metal bindingi147ZincUniRule annotation1
Metal bindingi182ZincUniRule annotation1
Metal bindingi185ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8
Nucleotide bindingi87 – 90ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processDNA synthesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:YPO2176, y2145, YP_1975
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001750511 – 196Thymidine kinaseAdd BLAST196

Proteomic databases

PaxDbiQ8ZEJ1
PRIDEiQ8ZEJ1

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi187410.y2145

Structurei

3D structure databases

ProteinModelPortaliQ8ZEJ1
SMRiQ8ZEJ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104 Bacteria
COG1435 LUCA
HOGENOMiHOG000076391
KOiK00857
OMAiKEQFGWI

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZEJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLYFYYSA MNAGKSTALL QSSYNYQERG MRTLVFTAEI DNRFGVGTVS
60 70 80 90 100
SRIGLSSQAQ LYNSGTSLLS IIAAEHQDTP IHCILLDECQ FLTKEQVQEL
110 120 130 140 150
CQVVDELHLP VLCYGLRTDF LGELFPGSKY LLAWADKLVE LKTICHCGRK
160 170 180 190
ANMVLRLDEQ GRAVHNGEQV VIGGNESYVS VCRRHYKEAI KAACCS
Length:196
Mass (Da):21,897
Last modified:March 1, 2002 - v1
Checksum:iF3333069CBFA5958
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL20807.1
AE009952 Genomic DNA Translation: AAM85707.1
AE017042 Genomic DNA Translation: AAS62192.1
PIRiAD0265
RefSeqiWP_002210659.1, NZ_PDBR01000107.1
YP_002347150.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM85707; AAM85707; y2145
AAS62192; AAS62192; YP_1975
GeneIDi1175011
KEGGiype:YPO2176
ypk:y2145
ypm:YP_1975
PATRICifig|214092.21.peg.2568

Similar proteinsi

Entry informationi

Entry nameiKITH_YERPE
AccessioniPrimary (citable) accession number: Q8ZEJ1
Secondary accession number(s): Q0WEY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health