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Q8ZEG8

- TRPC_YERPE

UniProt

Q8ZEG8 - TRPC_YERPE

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Protein

Tryptophan biosynthesis protein TrpCF

Gene

trpC

Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity).By similarity

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.

Pathwayi

GO - Molecular functioni

  1. indole-3-glycerol-phosphate synthase activity Source: UniProtKB-EC
  2. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Isomerase, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciYPES214092:GKDD-2174-MONOMER.
UniPathwayiUPA00035; UER00042.
UPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan biosynthesis protein TrpCF
Including the following 2 domains:
Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
Short name:
IGPS
N-(5'-phospho-ribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trpC
Ordered Locus Names:YPO2205, y2049, YP_2003
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Tryptophan biosynthesis protein TrpCFPRO_0000154287Add
BLAST

Proteomic databases

PRIDEiQ8ZEG8.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiQ8ZEG8. 2 interactions.
STRINGi214092.YPO2205.

Structurei

3D structure databases

ProteinModelPortaliQ8ZEG8.
SMRiQ8ZEG8. Positions 25-475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 279279Indole-3-glycerol phosphate synthaseAdd
BLAST
Regioni280 – 475196N-(5'-phosphoribosyl)anthranilate isomeraseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the TrpC family.Curated
In the C-terminal section; belongs to the TrpF family.Curated

Phylogenomic databases

eggNOGiCOG0134.
HOGENOMiHOG000280458.
KOiK13498.
OMAiEKYFQGD.
OrthoDBiEOG6WT8JX.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
HAMAPiMF_00134_B. IGPS_B.
MF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 2 hits.
PROSITEiPS00614. IGPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZEG8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQETGGYKTE GYNVGSDKVD SDKTKTVLHQ IVHDKEIWVA ARKLQQPLTR
60 70 80 90 100
FQNEITQSQR DFYHALQGDK TVFILECKKA SPSKGVIRDN FNPAEIAGVY
110 120 130 140 150
KHYASAISVL TDEKYFQGSF DFLPQVSAAV TQPVLCKDFI IDAYQIQLAR
160 170 180 190 200
FYHADAILLM LSVLDDEAYR QLAAVAHSLN MGVLTEASNA EELERAITLG
210 220 230 240 250
AKVVGINNRD LRDLSIDLNR TRELAPRLPE GVTIISESGI SHYRQVRELS
260 270 280 290 300
QFANGFLIGS ALMSEPDLNA AVRRVLLGEN KVCGLTRAQD AATAYHAGAV
310 320 330 340 350
YGGLIFVDSS PRYVDIASAR TVISGAPLKY VGVFRHAEIE TVRQTAEQLS
360 370 380 390 400
LAAVQLHGHE DQQYINQLRK VLPADCQIWK ALSVGDTMPE RNLQQVERYV
410 420 430 440 450
LDHGTGGTGQ RFDWSLLADQ ALDNVLLAGG LGPDNCDVAA QLGCAGLDVN
460 470
SGVESAPGIK DPQRIAAVFQ ALRVY
Length:475
Mass (Da):52,117
Last modified:March 1, 2002 - v1
Checksum:i181CF84E2F15F2FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL20834.1.
AE009952 Genomic DNA. Translation: AAM85614.1.
AE017042 Genomic DNA. Translation: AAS62219.1.
PIRiAG0268.
RefSeqiNP_669363.1. NC_004088.1.
NP_993342.1. NC_005810.1.
YP_002347176.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM85614; AAM85614; y2049.
AAS62219; AAS62219; YP_2003.
GeneIDi1146996.
1175038.
2765813.
KEGGiype:YPO2205.
ypk:y2049.
ypm:YP_2003.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL20834.1 .
AE009952 Genomic DNA. Translation: AAM85614.1 .
AE017042 Genomic DNA. Translation: AAS62219.1 .
PIRi AG0268.
RefSeqi NP_669363.1. NC_004088.1.
NP_993342.1. NC_005810.1.
YP_002347176.1. NC_003143.1.

3D structure databases

ProteinModelPortali Q8ZEG8.
SMRi Q8ZEG8. Positions 25-475.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8ZEG8. 2 interactions.
STRINGi 214092.YPO2205.

Proteomic databases

PRIDEi Q8ZEG8.

Protocols and materials databases

DNASUi 1146996.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM85614 ; AAM85614 ; y2049 .
AAS62219 ; AAS62219 ; YP_2003 .
GeneIDi 1146996.
1175038.
2765813.
KEGGi ype:YPO2205.
ypk:y2049.
ypm:YP_2003.

Phylogenomic databases

eggNOGi COG0134.
HOGENOMi HOG000280458.
KOi K13498.
OMAi EKYFQGD.
OrthoDBi EOG6WT8JX.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00042 .
UPA00035 ; UER00043 .
BioCyci YPES214092:GKDD-2174-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 2 hits.
HAMAPi MF_00134_B. IGPS_B.
MF_00135. PRAI.
InterProi IPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 2 hits.
PROSITEi PS00614. IGPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiTRPC_YERPE
AccessioniPrimary (citable) accession number: Q8ZEG8
Secondary accession number(s): Q0WEW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2002
Last modified: October 1, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3