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Q8ZEG8

- TRPC_YERPE

UniProt

Q8ZEG8 - TRPC_YERPE

Protein

Tryptophan biosynthesis protein TrpCF

Gene

trpC

Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain By similarity.By similarity

    Catalytic activityi

    N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
    1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.

    Pathwayi

    GO - Molecular functioni

    1. indole-3-glycerol-phosphate synthase activity Source: UniProtKB-EC
    2. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tryptophan biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Isomerase, Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    BioCyciYPES214092:GKDD-2174-MONOMER.
    UniPathwayiUPA00035; UER00042.
    UPA00035; UER00043.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan biosynthesis protein TrpCF
    Including the following 2 domains:
    Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
    Short name:
    IGPS
    N-(5'-phospho-ribosyl)anthranilate isomerase (EC:5.3.1.24)
    Short name:
    PRAI
    Gene namesi
    Name:trpC
    Ordered Locus Names:YPO2205, y2049, YP_2003
    OrganismiYersinia pestis
    Taxonomic identifieri632 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 475475Tryptophan biosynthesis protein TrpCFPRO_0000154287Add
    BLAST

    Proteomic databases

    PRIDEiQ8ZEG8.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    IntActiQ8ZEG8. 2 interactions.
    STRINGi214092.YPO2205.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8ZEG8.
    SMRiQ8ZEG8. Positions 25-475.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 279279Indole-3-glycerol phosphate synthaseAdd
    BLAST
    Regioni280 – 475196N-(5'-phosphoribosyl)anthranilate isomeraseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the TrpC family.Curated
    In the C-terminal section; belongs to the TrpF family.Curated

    Phylogenomic databases

    eggNOGiCOG0134.
    HOGENOMiHOG000280458.
    KOiK13498.
    OMAiEKYFQGD.
    OrthoDBiEOG6WT8JX.

    Family and domain databases

    Gene3Di3.20.20.70. 2 hits.
    HAMAPiMF_00134_B. IGPS_B.
    MF_00135. PRAI.
    InterProiIPR013785. Aldolase_TIM.
    IPR013798. Indole-3-glycerol_P_synth.
    IPR001468. Indole-3-GlycerolPSynthase_CS.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00218. IGPS. 1 hit.
    PF00697. PRAI. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 2 hits.
    PROSITEiPS00614. IGPS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8ZEG8-1 [UniParc]FASTAAdd to Basket

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    MQETGGYKTE GYNVGSDKVD SDKTKTVLHQ IVHDKEIWVA ARKLQQPLTR    50
    FQNEITQSQR DFYHALQGDK TVFILECKKA SPSKGVIRDN FNPAEIAGVY 100
    KHYASAISVL TDEKYFQGSF DFLPQVSAAV TQPVLCKDFI IDAYQIQLAR 150
    FYHADAILLM LSVLDDEAYR QLAAVAHSLN MGVLTEASNA EELERAITLG 200
    AKVVGINNRD LRDLSIDLNR TRELAPRLPE GVTIISESGI SHYRQVRELS 250
    QFANGFLIGS ALMSEPDLNA AVRRVLLGEN KVCGLTRAQD AATAYHAGAV 300
    YGGLIFVDSS PRYVDIASAR TVISGAPLKY VGVFRHAEIE TVRQTAEQLS 350
    LAAVQLHGHE DQQYINQLRK VLPADCQIWK ALSVGDTMPE RNLQQVERYV 400
    LDHGTGGTGQ RFDWSLLADQ ALDNVLLAGG LGPDNCDVAA QLGCAGLDVN 450
    SGVESAPGIK DPQRIAAVFQ ALRVY 475
    Length:475
    Mass (Da):52,117
    Last modified:March 1, 2002 - v1
    Checksum:i181CF84E2F15F2FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL20834.1.
    AE009952 Genomic DNA. Translation: AAM85614.1.
    AE017042 Genomic DNA. Translation: AAS62219.1.
    PIRiAG0268.
    RefSeqiNP_669363.1. NC_004088.1.
    NP_993342.1. NC_005810.1.
    YP_002347176.1. NC_003143.1.

    Genome annotation databases

    EnsemblBacteriaiAAM85614; AAM85614; y2049.
    AAS62219; AAS62219; YP_2003.
    GeneIDi1146996.
    1175038.
    2765813.
    KEGGiype:YPO2205.
    ypk:y2049.
    ypm:YP_2003.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL20834.1 .
    AE009952 Genomic DNA. Translation: AAM85614.1 .
    AE017042 Genomic DNA. Translation: AAS62219.1 .
    PIRi AG0268.
    RefSeqi NP_669363.1. NC_004088.1.
    NP_993342.1. NC_005810.1.
    YP_002347176.1. NC_003143.1.

    3D structure databases

    ProteinModelPortali Q8ZEG8.
    SMRi Q8ZEG8. Positions 25-475.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8ZEG8. 2 interactions.
    STRINGi 214092.YPO2205.

    Proteomic databases

    PRIDEi Q8ZEG8.

    Protocols and materials databases

    DNASUi 1146996.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM85614 ; AAM85614 ; y2049 .
    AAS62219 ; AAS62219 ; YP_2003 .
    GeneIDi 1146996.
    1175038.
    2765813.
    KEGGi ype:YPO2205.
    ypk:y2049.
    ypm:YP_2003.

    Phylogenomic databases

    eggNOGi COG0134.
    HOGENOMi HOG000280458.
    KOi K13498.
    OMAi EKYFQGD.
    OrthoDBi EOG6WT8JX.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00042 .
    UPA00035 ; UER00043 .
    BioCyci YPES214092:GKDD-2174-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 2 hits.
    HAMAPi MF_00134_B. IGPS_B.
    MF_00135. PRAI.
    InterProi IPR013785. Aldolase_TIM.
    IPR013798. Indole-3-glycerol_P_synth.
    IPR001468. Indole-3-GlycerolPSynthase_CS.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00218. IGPS. 1 hit.
    PF00697. PRAI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 2 hits.
    PROSITEi PS00614. IGPS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CO-92 / Biovar Orientalis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIM10+ / Biovar Mediaevalis.
    3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
      Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
      , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
      DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 91001 / Biovar Mediaevalis.

    Entry informationi

    Entry nameiTRPC_YERPE
    AccessioniPrimary (citable) accession number: Q8ZEG8
    Secondary accession number(s): Q0WEW2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3