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Q8ZEB6

- FUMC_YERPE

UniProt

Q8ZEB6 - FUMC_YERPE

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Protein
Fumarate hydratase class II
Gene
fumC, YPO2264, y2106, YP_2061
Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible addition of water to fumarate to give L-malate By similarity.UniRule annotation

Catalytic activityi

(S)-malate = fumarate + H2O.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei188 – 1881Proton donor/acceptor By similarity
Active sitei318 – 3181 By similarity
Binding sitei319 – 3191Substrate By similarity
Sitei331 – 3311Important for catalytic activity By similarity

GO - Molecular functioni

  1. fumarate hydratase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. fumarate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

BioCyciYPES214092:GKDD-2231-MONOMER.
UniPathwayiUPA00223; UER01007.

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate hydratase class II (EC:4.2.1.2)
Short name:
Fumarase C
Gene namesi
Name:fumC
Ordered Locus Names:YPO2264, y2106, YP_2061
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. tricarboxylic acid cycle enzyme complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Fumarate hydratase class IIUniRule annotation
PRO_0000161331Add
BLAST

Proteomic databases

PRIDEiQ8ZEB6.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi214092.YPO2264.

Structurei

3D structure databases

ProteinModelPortaliQ8ZEB6.
SMRiQ8ZEB6. Positions 5-460.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni98 – 1003Substrate binding By similarity
Regioni129 – 1324B site By similarity
Regioni139 – 1413Substrate binding By similarity
Regioni187 – 1882Substrate binding By similarity
Regioni324 – 3263Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0114.
HOGENOMiHOG000061736.
KOiK01679.
OMAiNAHPEYH.
OrthoDBiEOG6V1M4M.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00743. FumaraseC.
InterProiIPR005677. Fum_hydII.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00979. fumC_II. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZEB6-1 [UniParc]FASTAAdd to Basket

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MATTRSEKDS MGSIDVPANQ LWGAQTQRSL AHFRISQEKM PTELIHALAL    50
TKRAAAQVNM DLGLLPAERA KAIMRAADEV LDGAHPTEFP LAIWQTGSGT 100
QTNMNMNEVL ANRASELLGG ARGNNRLVHP NDDVNKSQSS NDVFPTAMHV 150
AAVMGVSEHL LPELKVLQKT LADKAEAYRD IVKIGRTHLQ DATPLTLGQE 200
ISGWAAMLSH SVRHIEATLP HLCELALGGT AVGTGLNTHP EYAVRVANEI 250
ATLTRQPFIT APNKFESLGT CDALVHGHGA LKGLAASLMK IANDVRWLSS 300
GPRCGIGEIS IPENEPGSSI MPGKVNPTQC EAMTMLCAQV MGNDVAINIG 350
GASGNFELNV FRPLVIHNFL QSVRLLADGM RGFNEHCALG IEPNRDRITQ 400
LLNESLMLVT ALNTHIGYDK AAEIAKKAHK EGLTLKAAAM ALGYLTDAEF 450
DEWVRPEDMV GSMKK 465
Length:465
Mass (Da):50,129
Last modified:March 1, 2002 - v1
Checksum:iACCDACBCD38851A7
GO

Sequence cautioni

The sequence AAS62274.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL20891.1.
AE009952 Genomic DNA. Translation: AAM85669.1.
AE017042 Genomic DNA. Translation: AAS62274.1. Different initiation.
PIRiAH0275.
RefSeqiNP_669418.1. NC_004088.1.
YP_008853946.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM85669; AAM85669; y2106.
AAS62274; AAS62274; YP_2061.
GeneIDi1147053.
17699570.
KEGGiype:YPO2263a.
ypk:y2106.
PATRICi18594167. VBIYerPes7843_2794.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL20891.1 .
AE009952 Genomic DNA. Translation: AAM85669.1 .
AE017042 Genomic DNA. Translation: AAS62274.1 . Different initiation.
PIRi AH0275.
RefSeqi NP_669418.1. NC_004088.1.
YP_008853946.1. NC_003143.1.

3D structure databases

ProteinModelPortali Q8ZEB6.
SMRi Q8ZEB6. Positions 5-460.
ModBasei Search...

Protein-protein interaction databases

STRINGi 214092.YPO2264.

Proteomic databases

PRIDEi Q8ZEB6.

Protocols and materials databases

DNASUi 1147053.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM85669 ; AAM85669 ; y2106 .
AAS62274 ; AAS62274 ; YP_2061 .
GeneIDi 1147053.
17699570.
KEGGi ype:YPO2263a.
ypk:y2106.
PATRICi 18594167. VBIYerPes7843_2794.

Phylogenomic databases

eggNOGi COG0114.
HOGENOMi HOG000061736.
KOi K01679.
OMAi NAHPEYH.
OrthoDBi EOG6V1M4M.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01007 .
BioCyci YPES214092:GKDD-2231-MONOMER.

Family and domain databases

Gene3Di 1.10.275.10. 1 hit.
HAMAPi MF_00743. FumaraseC.
InterProi IPR005677. Fum_hydII.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view ]
PANTHERi PTHR11444. PTHR11444. 1 hit.
Pfami PF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view ]
PRINTSi PR00149. FUMRATELYASE.
SUPFAMi SSF48557. SSF48557. 1 hit.
TIGRFAMsi TIGR00979. fumC_II. 1 hit.
PROSITEi PS00163. FUMARATE_LYASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiFUMC_YERPE
AccessioniPrimary (citable) accession number: Q8ZEB6
Secondary accession number(s): Q0WEQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: March 1, 2002
Last modified: June 11, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors By similarity.

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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