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Q8ZE82

- FNR_YERPE

UniProt

Q8ZE82 - FNR_YERPE

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Protein

Fumarate and nitrate reduction regulatory protein

Gene

fnr

Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism. When the terminal electron acceptor, O2, is no longer available, it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration (By similarity).By similarity

Cofactori

Binds 1 4Fe-4S cluster per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi20 – 201Iron-sulfur (4Fe-4S)Sequence Analysis
Metal bindingi23 – 231Iron-sulfur (4Fe-4S)Sequence Analysis
Metal bindingi29 – 291Iron-sulfur (4Fe-4S)Sequence Analysis
Metal bindingi122 – 1221Iron-sulfur (4Fe-4S)Sequence Analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi197 – 21620H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

4Fe-4S, DNA-binding, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciYPES214092:GKDD-2268-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate and nitrate reduction regulatory protein
Gene namesi
Name:fnr
Ordered Locus Names:YPO2300, y2132, YP_2085
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Fumarate and nitrate reduction regulatory proteinPRO_0000100171Add
BLAST

Proteomic databases

PRIDEiQ8ZE82.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi214092.YPO2300.

Structurei

3D structure databases

ProteinModelPortaliQ8ZE82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini164 – 23774HTH crp-typePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 2910Essential for the oxygen-regulated activityBy similarity
Regioni47 – 504Activating region 2ASequence Analysis
Regioni60 – 612Activating region 3ASequence Analysis
Regioni71 – 755Activating region 1ASequence Analysis
Regioni81 – 811Activating region 3BSequence Analysis
Regioni85 – 873Activating region 3CSequence Analysis
Regioni112 – 1121Activating region 3DSequence Analysis
Regioni116 – 1216Activating region 1BSequence Analysis
Regioni123 – 1242Activating region 2BSequence Analysis
Regioni127 – 1282Activating region 2CSequence Analysis
Regioni140 – 15920DimerizationSequence AnalysisAdd
BLAST
Regioni181 – 19111Activating region 1CSequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000186461.
KOiK01420.
OMAiFSANQFR.
OrthoDBiEOG6RVFWF.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view]
PRINTSiPR00034. HTHCRP.
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZE82-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIPEKRVIRR IQSGGYAIHC QDCSISQLCI PFTLNEHELD QLDNIIERKK
60 70 80 90 100
PIQKGQALFK AGDELKSLYA IRSGTIKSYT ITEEGDEQIT GFHLAGDLVG
110 120 130 140 150
FDAISNLQHP SFAQALETSM VCEIPFDTLD DLSGKMPNLR QQIMRLMSGE
160 170 180 190 200
IKGDQDMILL LSKKNAEERL AAFIYNLSHR FAQRGFSPRE FRLTMTRGDI
210 220 230 240 250
GNYLGLTVET ISRLLGRFQK SNILSVKGKY ITIENNEALA QLAGNPKPRL
Length:250
Mass (Da):28,133
Last modified:March 1, 2002 - v1
Checksum:i2AE591FD8BFF33F3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL20928.1.
AE009952 Genomic DNA. Translation: AAM85694.1.
AE017042 Genomic DNA. Translation: AAS62296.1.
PIRiAE0280.
RefSeqiNP_669443.1. NC_004088.1.
NP_993419.1. NC_005810.1.
YP_002347267.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM85694; AAM85694; y2132.
AAS62296; AAS62296; YP_2085.
GeneIDi1147079.
1175132.
2765092.
KEGGiype:YPO2300.
ypk:y2132.
ypm:YP_2085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL20928.1 .
AE009952 Genomic DNA. Translation: AAM85694.1 .
AE017042 Genomic DNA. Translation: AAS62296.1 .
PIRi AE0280.
RefSeqi NP_669443.1. NC_004088.1.
NP_993419.1. NC_005810.1.
YP_002347267.1. NC_003143.1.

3D structure databases

ProteinModelPortali Q8ZE82.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 214092.YPO2300.

Proteomic databases

PRIDEi Q8ZE82.

Protocols and materials databases

DNASUi 1147079.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM85694 ; AAM85694 ; y2132 .
AAS62296 ; AAS62296 ; YP_2085 .
GeneIDi 1147079.
1175132.
2765092.
KEGGi ype:YPO2300.
ypk:y2132.
ypm:YP_2085.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000186461.
KOi K01420.
OMAi FSANQFR.
OrthoDBi EOG6RVFWF.

Enzyme and pathway databases

BioCyci YPES214092:GKDD-2268-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view ]
PRINTSi PR00034. HTHCRP.
SMARTi SM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiFNR_YERPE
AccessioniPrimary (citable) accession number: Q8ZE82
Secondary accession number(s): Q0WEM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3