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Q8ZE82

- FNR_YERPE

UniProt

Q8ZE82 - FNR_YERPE

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Protein
Fumarate and nitrate reduction regulatory protein
Gene
fnr, YPO2300, y2132, YP_2085
Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism. When the terminal electron acceptor, O2, is no longer available, it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration By similarity.

Cofactori

Binds 1 4Fe-4S cluster per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi20 – 201Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi23 – 231Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi29 – 291Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi122 – 1221Iron-sulfur (4Fe-4S) Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi197 – 21620H-T-H motif By similarity
Add
BLAST

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

4Fe-4S, DNA-binding, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciYPES214092:GKDD-2268-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate and nitrate reduction regulatory protein
Gene namesi
Name:fnr
Ordered Locus Names:YPO2300, y2132, YP_2085
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Fumarate and nitrate reduction regulatory protein
PRO_0000100171Add
BLAST

Proteomic databases

PRIDEiQ8ZE82.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi214092.YPO2300.

Structurei

3D structure databases

ProteinModelPortaliQ8ZE82.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini164 – 23774HTH crp-type
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 2910Essential for the oxygen-regulated activity By similarity
Regioni47 – 504Activating region 2A Reviewed prediction
Regioni60 – 612Activating region 3A Reviewed prediction
Regioni71 – 755Activating region 1A Reviewed prediction
Regioni81 – 811Activating region 3B Reviewed prediction
Regioni85 – 873Activating region 3C Reviewed prediction
Regioni112 – 1121Activating region 3D Reviewed prediction
Regioni116 – 1216Activating region 1B Reviewed prediction
Regioni123 – 1242Activating region 2B Reviewed prediction
Regioni127 – 1282Activating region 2C Reviewed prediction
Regioni140 – 15920Dimerization Reviewed prediction
Add
BLAST
Regioni181 – 19111Activating region 1C Reviewed prediction
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000186461.
KOiK01420.
OMAiFSANQFR.
OrthoDBiEOG6RVFWF.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view]
PRINTSiPR00034. HTHCRP.
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZE82-1 [UniParc]FASTAAdd to Basket

« Hide

MIPEKRVIRR IQSGGYAIHC QDCSISQLCI PFTLNEHELD QLDNIIERKK    50
PIQKGQALFK AGDELKSLYA IRSGTIKSYT ITEEGDEQIT GFHLAGDLVG 100
FDAISNLQHP SFAQALETSM VCEIPFDTLD DLSGKMPNLR QQIMRLMSGE 150
IKGDQDMILL LSKKNAEERL AAFIYNLSHR FAQRGFSPRE FRLTMTRGDI 200
GNYLGLTVET ISRLLGRFQK SNILSVKGKY ITIENNEALA QLAGNPKPRL 250
Length:250
Mass (Da):28,133
Last modified:March 1, 2002 - v1
Checksum:i2AE591FD8BFF33F3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL20928.1.
AE009952 Genomic DNA. Translation: AAM85694.1.
AE017042 Genomic DNA. Translation: AAS62296.1.
PIRiAE0280.
RefSeqiNP_669443.1. NC_004088.1.
NP_993419.1. NC_005810.1.
YP_002347267.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM85694; AAM85694; y2132.
AAS62296; AAS62296; YP_2085.
GeneIDi1147079.
1175132.
2765092.
KEGGiype:YPO2300.
ypk:y2132.
ypm:YP_2085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL20928.1 .
AE009952 Genomic DNA. Translation: AAM85694.1 .
AE017042 Genomic DNA. Translation: AAS62296.1 .
PIRi AE0280.
RefSeqi NP_669443.1. NC_004088.1.
NP_993419.1. NC_005810.1.
YP_002347267.1. NC_003143.1.

3D structure databases

ProteinModelPortali Q8ZE82.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 214092.YPO2300.

Proteomic databases

PRIDEi Q8ZE82.

Protocols and materials databases

DNASUi 1147079.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM85694 ; AAM85694 ; y2132 .
AAS62296 ; AAS62296 ; YP_2085 .
GeneIDi 1147079.
1175132.
2765092.
KEGGi ype:YPO2300.
ypk:y2132.
ypm:YP_2085.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000186461.
KOi K01420.
OMAi FSANQFR.
OrthoDBi EOG6RVFWF.

Enzyme and pathway databases

BioCyci YPES214092:GKDD-2268-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view ]
PRINTSi PR00034. HTHCRP.
SMARTi SM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiFNR_YERPE
AccessioniPrimary (citable) accession number: Q8ZE82
Secondary accession number(s): Q0WEM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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