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Q8ZE82 (FNR_YERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fumarate and nitrate reduction regulatory protein
Gene names
Name:fnr
Ordered Locus Names:YPO2300, y2132, YP_2085
OrganismYersinia pestis [Reference proteome] [HAMAP]
Taxonomic identifier632 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism. When the terminal electron acceptor, O2, is no longer available, it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration By similarity.

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Contains 1 cyclic nucleotide-binding domain.

Contains 1 HTH crp-type DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 250250Fumarate and nitrate reduction regulatory protein
PRO_0000100171

Regions

Domain164 – 23774HTH crp-type
DNA binding197 – 21620H-T-H motif By similarity
Region20 – 2910Essential for the oxygen-regulated activity By similarity
Region47 – 504Activating region 2A Potential
Region60 – 612Activating region 3A Potential
Region71 – 755Activating region 1A Potential
Region811Activating region 3B Potential
Region85 – 873Activating region 3C Potential
Region1121Activating region 3D Potential
Region116 – 1216Activating region 1B Potential
Region123 – 1242Activating region 2B Potential
Region127 – 1282Activating region 2C Potential
Region140 – 15920Dimerization Potential
Region181 – 19111Activating region 1C Potential

Sites

Metal binding201Iron-sulfur (4Fe-4S) Potential
Metal binding231Iron-sulfur (4Fe-4S) Potential
Metal binding291Iron-sulfur (4Fe-4S) Potential
Metal binding1221Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
Q8ZE82 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 2AE591FD8BFF33F3

FASTA25028,133
        10         20         30         40         50         60 
MIPEKRVIRR IQSGGYAIHC QDCSISQLCI PFTLNEHELD QLDNIIERKK PIQKGQALFK 

        70         80         90        100        110        120 
AGDELKSLYA IRSGTIKSYT ITEEGDEQIT GFHLAGDLVG FDAISNLQHP SFAQALETSM 

       130        140        150        160        170        180 
VCEIPFDTLD DLSGKMPNLR QQIMRLMSGE IKGDQDMILL LSKKNAEERL AAFIYNLSHR 

       190        200        210        220        230        240 
FAQRGFSPRE FRLTMTRGDI GNYLGLTVET ISRLLGRFQK SNILSVKGKY ITIENNEALA 

       250 
QLAGNPKPRL 

« Hide

References

[1]"Genome sequence of Yersinia pestis, the causative agent of plague."
Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. expand/collapse author list , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.
Nature 413:523-527(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CO-92 / Biovar Orientalis.
[2]"Genome sequence of Yersinia pestis KIM."
Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. expand/collapse author list , Matson J.S., Blattner F.R., Perry R.D.
J. Bacteriol. 184:4601-4611(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KIM10+ / Biovar Mediaevalis.
[3]"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. expand/collapse author list , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL590842 Genomic DNA. Translation: CAL20928.1.
AE009952 Genomic DNA. Translation: AAM85694.1.
AE017042 Genomic DNA. Translation: AAS62296.1.
PIRAE0280.
RefSeqNP_669443.1. NC_004088.1.
NP_993419.1. NC_005810.1.
YP_002347267.1. NC_003143.1.

3D structure databases

ProteinModelPortalQ8ZE82.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING214092.YPO2300.

Proteomic databases

PRIDEQ8ZE82.

Protocols and materials databases

DNASU1147079.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM85694; AAM85694; y2132.
AAS62296; AAS62296; YP_2085.
GeneID1147079.
1175132.
2765092.
KEGGype:YPO2300.
ypk:y2132.
ypm:YP_2085.

Phylogenomic databases

eggNOGCOG0664.
HOGENOMHOG000186461.
KOK01420.
OMAFSANQFR.
OrthoDBEOG6RVFWF.

Enzyme and pathway databases

BioCycYPES214092:GKDD-2268-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view]
PRINTSPR00034. HTHCRP.
SMARTSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFNR_YERPE
AccessionPrimary (citable) accession number: Q8ZE82
Secondary accession number(s): Q0WEM1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families