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Protein

5'-deoxynucleotidase YPO2559

Gene

YPO2559

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the strictly specific dephosphorylation of 2'-deoxyribonucleoside 5'-monophosphates.UniRule annotation

Catalytic activityi

A 2'-deoxyribonucleoside 5'-monophosphate + H2O = a 2'-deoxyribonucleoside + phosphate.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei16Appears to be important in orienting the phosphate for catalysisUniRule annotation1
Metal bindingi31Divalent metal cation; via tele nitrogenUniRule annotation1
Binding sitei31SubstrateUniRule annotation1
Metal bindingi66Divalent metal cation; via tele nitrogenUniRule annotation1
Metal bindingi67Divalent metal cationUniRule annotation1
Binding sitei67SubstrateUniRule annotation1
Metal bindingi135Divalent metal cationUniRule annotation1
Binding sitei135SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
5'-deoxynucleotidase YPO2559UniRule annotation (EC:3.1.3.89UniRule annotation)
Alternative name(s):
5'-deoxyribonucleotidaseUniRule annotation
Nucleoside 5'-monophosphate phosphohydrolaseUniRule annotation
Gene namesi
Ordered Locus Names:YPO2559, y1627, YP_2370
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000950651 – 1975'-deoxynucleotidase YPO2559Add BLAST197

Proteomic databases

PaxDbiQ8ZDK3

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi187410.y1627

Structurei

3D structure databases

ProteinModelPortaliQ8ZDK3
SMRiQ8ZDK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 140HDPROSITE-ProRule annotationAdd BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni16 – 17Substrate bindingUniRule annotation2
Regioni75 – 78Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the 5DNU family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DK2 Bacteria
COG1896 LUCA
HOGENOMiHOG000276964
KOiK08722
OMAiNQSHFFA

Family and domain databases

HAMAPiMF_01100 5DNU, 1 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
IPR006674 HD_domain
IPR022971 YfbR
PfamiView protein in Pfam
PF13023 HD_3, 1 hit
SMARTiView protein in SMART
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS51831 HD, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZDK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHFFAHLSR LKLINRWPLM RNVRTENVSE HSLQVAFVAH ALAIIKNRKF
60 70 80 90 100
NGNLNAERIA LLAMYHDASE VITGDLPTPI KYHNPKIAHE YKKIEKVAQQ
110 120 130 140 150
KLIEMLPKEL QHDFRCLLDE HYYSEEEKAL VKQADALCAY LKCLEELSAG
160 170 180 190
NNEFIQAKAR LEKTLAIRQS PEMDYFMAVF VPSFSLSLDE ISLDSLD
Length:197
Mass (Da):22,729
Last modified:March 1, 2002 - v1
Checksum:iB3AC752101903423
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL21184.1
AE009952 Genomic DNA Translation: AAM85196.1
AE017042 Genomic DNA Translation: AAS62575.1
PIRiAE0312
RefSeqiWP_002210283.1, NZ_PDBR01000026.1
YP_002347520.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM85196; AAM85196; y1627
AAS62575; AAS62575; YP_2370
GeneIDi1175390
KEGGiype:YPO2559
ypj:CH55_52
ypk:y1627
ypl:CH46_2556
ypm:YP_2370
ypv:BZ15_978
ypw:CH59_93
PATRICifig|214092.21.peg.2983

Similar proteinsi

Entry informationi

Entry namei5DNU_YERPE
AccessioniPrimary (citable) accession number: Q8ZDK3
Secondary accession number(s): Q0WDW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health