ackA

Functionⁱ

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityⁱ

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactorⁱ

Mg²⁺UniRule annotation, Mn²⁺UniRule annotationNote: Mg²⁺. Can also accept Mn²⁺.UniRule annotation

Pathwayⁱ: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:

Acetate kinase (ackA), Acetate kinase (ackA)
Phosphate acetyltransferase (pta)

This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	10	MagnesiumUniRule annotation	1
Binding siteⁱ	17	ATPUniRule annotation	1
Binding siteⁱ	91	SubstrateUniRule annotation	1
Active siteⁱ	150	Proton donor/acceptorUniRule annotation	1
Siteⁱ	182	Transition state stabilizerUniRule annotation	1
Siteⁱ	243	Transition state stabilizerUniRule annotation	1
Metal bindingⁱ	387	MagnesiumUniRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	210 – 214	ATPUniRule annotation	5
Nucleotide bindingⁱ	285 – 287	ATPUniRule annotation	3
Nucleotide bindingⁱ	333 – 337	ATPUniRule annotation	5

GO - Molecular functionⁱ

acetate kinase activity Source: UniProtKB-EC
ATP binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
organic acid metabolic process Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayⁱ	UPA00340; UER00458.

UniPathwayⁱ

UPA00340; UER00458.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation) Alternative name(s): AcetokinaseUniRule annotation
Gene namesⁱ	Name:ackAUniRule annotation Ordered Locus Names:YPO2566, y1622, YP_2377
Organismⁱ	Yersinia pestis
Taxonomic identifierⁱ	632 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Yersiniaceae › Yersinia › Yersinia pseudotuberculosis complex
Proteomesⁱ	UP000000815 Componentⁱ: Chromosome UP000001019 Componentⁱ: Chromosome UP000002490 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00020

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000107646	1 – 400	Acetate kinaseAdd BLAST		400

Proteomic databases

PaxDbⁱ	Q8ZDJ6.

PaxDbⁱ

Q8ZDJ6.

Interactionⁱ

Subunit structureⁱ

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActⁱ	Q8ZDJ6. 1 interactor.
STRINGⁱ	187410.y1622.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8ZDJ6.
SMRⁱ	Q8ZDJ6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105C6H. Bacteria. COG0282. LUCA.
HOGENOMⁱ	HOG000288398.
KEGG Orthology (KO) More...KOⁱ	K00925.
OMAⁱ	WKALTGT.

Family and domain databases

HAMAPⁱ	MF_00020. Acetate_kinase. 1 hit.
InterProⁱ	View protein in InterPro IPR004372. Ac/propionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS.
PANTHERⁱ	PTHR21060. PTHR21060. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00871. Acetate_kinase. 1 hit.
PIRSFⁱ	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSⁱ	PR00471. ACETATEKNASE.
TIGRFAMsⁱ	TIGR00016. ackA. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8ZDJ6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSKLVLVLN CGSSSLKFAI IDATNGEEHI SGLAECFHLP EARIKWKVDG 
        60         70         80         90        100
GKQEAALGAG AAHSEALNFI VNTILAQKPA LSAQLTAIGH RIVHGGEKFT 
       110        120        130        140        150
SSVIVTEDVI QGIKDSIPFA PLHNPAHLIG IAEALKSFPN LADKNVAVFD 
       160        170        180        190        200
TAFHQTMPEE SYLYALPYSL YKDHGIRRYG AHGTSHFYVS QEAAKILNKP 
       210        220        230        240        250
LEELNVITCH LGNGGSVTAV RNGKCVDTSM GLTPLEGLVM GTRSGDLDPA 
       260        270        280        290        300
IIFHLHDAMG MSVDQINTLL TKESGLLGLT EVTSDCRYVE DNYATKADAK 
       310        320        330        340        350
RAMDVFCHRL AKYIGSYTAL MDGRLDAVVF TGGIGENAAM VRELTLDKLG 
       360        370        380        390        400
LLGFEIDHER NMAARFGKSG TITKDSSRLA LVIPTNEELV IAQDAARLTA

Length:400

Mass (Da):43,018

Last modified:March 1, 2002 - v1

Checksum:ⁱ21BA6CC5B1A2F716

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL590842 Genomic DNA. Translation: CAL21191.1. AE009952 Genomic DNA. Translation: AAM85191.1. AE017042 Genomic DNA. Translation: AAS62582.1.
PIRⁱ	AD0313.
NCBI Reference Sequences More...RefSeqⁱ	WP_002210288.1. NZ_PDBR01000026.1. YP_002347527.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaⁱ	AAM85191; AAM85191; y1622. AAS62582; AAS62582; YP_2377.
GeneIDⁱ	1175397.
KEGGⁱ	ype:YPO2566. ypk:y1622. ypm:YP_2377.
PATRICⁱ	fig\|214092.21.peg.2988.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8ZDJ6	Q1C6A1 A9R6M9 Q1CHP3 A4TM44 A0A154T778 A0A0M1V8B7 A0A0E1NMJ4 A0A208S4L8 UPI0005789091 UPI000578B308 +5	Yersinia pestis bv. Antiqua (strain Antiqua) Yersinia pestis bv. Antiqua (strain Angola) Yersinia pestis bv. Antiqua (strain Nepal516) Yersinia pestis (strain Pestoides F) Yersinia pestis Yersinia pestis biovar Orientalis str. IP275 Yersinia pestis subsp. microtus	400	UniRef100_Q1C6A1	Cluster: Acetate kinase	16

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8ZDJ6	Q1C6A1 A9R6M9 Q1CHP3 A4TM44 A0A154T778 A0A0M1V8B7 A0A0E1NMJ4 A0A208S4L8 UPI0005789091 UPI000578B308 +55	Yersinia pestis bv. Antiqua (strain Antiqua) Yersinia pestis bv. Antiqua (strain Angola) Yersinia pestis bv. Antiqua (strain Nepal516) Yersinia pestis (strain Pestoides F) Yersinia pestis Yersinia pestis biovar Orientalis str. IP275 Yersinia pestis subsp. microtus Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) Yersinia pseudotuberculosis serotype IB (strain PB1/+) Yersinia intermedia And more	400	UniRef90_Q1C6A1	Cluster: Acetate kinase	66

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8ZDJ6	P0A6A5 P0A6A4 P0A6A3 A0A024KX90 A0A222QMS4 W1BE33 A0A2H1BLW9 A0A237FTL1 A0A0I0NHH7 C3T282 +1353	Escherichia coli O157:H7 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) Escherichia coli (strain K12) Escherichia coli D6-113.11 Escherichia coli NCCP15648 Klebsiella pneumoniae IS22 Escherichia coli O55:H7 str. USDA 5905 Shigella boydii Shigella sonnei Escherichia coli And more	400	UniRef50_P0A6A5	Cluster: Acetate kinase	1,364

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL590842 Genomic DNA. Translation: CAL21191.1. AE009952 Genomic DNA. Translation: AAM85191.1. AE017042 Genomic DNA. Translation: AAS62582.1.
PIRⁱ	AD0313.
NCBI Reference Sequences More...RefSeqⁱ	WP_002210288.1. NZ_PDBR01000026.1. YP_002347527.1. NC_003143.1.

3D structure databases

ProteinModelPortalⁱ	Q8ZDJ6.
SMRⁱ	Q8ZDJ6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q8ZDJ6. 1 interactor.
STRINGⁱ	187410.y1622.

Proteomic databases

PaxDbⁱ	Q8ZDJ6.

PaxDbⁱ

Q8ZDJ6.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1146569.
Structural Biology Knowledgebase	Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAM85191; AAM85191; y1622. AAS62582; AAS62582; YP_2377.
GeneIDⁱ	1175397.
KEGGⁱ	ype:YPO2566. ypk:y1622. ypm:YP_2377.
PATRICⁱ	fig\|214092.21.peg.2988.

Phylogenomic databases

eggNOGⁱ	ENOG4105C6H. Bacteria. COG0282. LUCA.
HOGENOMⁱ	HOG000288398.
KEGG Orthology (KO) More...KOⁱ	K00925.
OMAⁱ	WKALTGT.

Enzyme and pathway databases

UniPathwayⁱ	UPA00340; UER00458.

UniPathwayⁱ

UPA00340; UER00458.

Family and domain databases

HAMAPⁱ	MF_00020. Acetate_kinase. 1 hit.
InterProⁱ	View protein in InterPro IPR004372. Ac/propionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS.
PANTHERⁱ	PTHR21060. PTHR21060. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00871. Acetate_kinase. 1 hit.
PIRSFⁱ	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSⁱ	PR00471. ACETATEKNASE.
TIGRFAMsⁱ	TIGR00016. ackA. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACKA_YERPE
Accessionⁱ	Q8ZDJ6Primary (citable) accession number: Q8ZDJ6 Secondary accession number(s): Q0WDW1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
	Last sequence update:	March 1, 2002
	Last modified:	March 28, 2018
	This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8ZDJ6 (ACKA_YERPE)

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Acetate kinase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: acetyl-CoA biosynthesis

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: acetyl-CoA biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ