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Protein

Acetate kinase

Gene

ackA

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA), Acetate kinase (ackA)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi10MagnesiumUniRule annotation1
Binding sitei17ATPUniRule annotation1
Binding sitei91SubstrateUniRule annotation1
Active sitei150Proton donor/acceptorUniRule annotation1
Sitei182Transition state stabilizerUniRule annotation1
Sitei243Transition state stabilizerUniRule annotation1
Metal bindingi387MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi210 – 214ATPUniRule annotation5
Nucleotide bindingi285 – 287ATPUniRule annotation3
Nucleotide bindingi333 – 337ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:YPO2566, y1622, YP_2377
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001076461 – 400Acetate kinaseAdd BLAST400

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiQ8ZDJ6. 1 interactor.
STRINGi187410.y1622.

Structurei

3D structure databases

ProteinModelPortaliQ8ZDJ6.
SMRiQ8ZDJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6H. Bacteria.
COG0282. LUCA.
HOGENOMiHOG000288398.
KOiK00925.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiView protein in InterPro
IPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiView protein in Pfam
PF00871. Acetate_kinase. 1 hit.
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiView protein in PROSITE
PS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZDJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKLVLVLN CGSSSLKFAI IDATNGEEHI SGLAECFHLP EARIKWKVDG
60 70 80 90 100
GKQEAALGAG AAHSEALNFI VNTILAQKPA LSAQLTAIGH RIVHGGEKFT
110 120 130 140 150
SSVIVTEDVI QGIKDSIPFA PLHNPAHLIG IAEALKSFPN LADKNVAVFD
160 170 180 190 200
TAFHQTMPEE SYLYALPYSL YKDHGIRRYG AHGTSHFYVS QEAAKILNKP
210 220 230 240 250
LEELNVITCH LGNGGSVTAV RNGKCVDTSM GLTPLEGLVM GTRSGDLDPA
260 270 280 290 300
IIFHLHDAMG MSVDQINTLL TKESGLLGLT EVTSDCRYVE DNYATKADAK
310 320 330 340 350
RAMDVFCHRL AKYIGSYTAL MDGRLDAVVF TGGIGENAAM VRELTLDKLG
360 370 380 390 400
LLGFEIDHER NMAARFGKSG TITKDSSRLA LVIPTNEELV IAQDAARLTA
Length:400
Mass (Da):43,018
Last modified:March 1, 2002 - v1
Checksum:i21BA6CC5B1A2F716
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL21191.1.
AE009952 Genomic DNA. Translation: AAM85191.1.
AE017042 Genomic DNA. Translation: AAS62582.1.
PIRiAD0313.
RefSeqiWP_002210288.1. NZ_LT605019.1.
YP_002347527.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM85191; AAM85191; y1622.
AAS62582; AAS62582; YP_2377.
GeneIDi1175397.
KEGGiype:YPO2566.
ypk:y1622.
ypm:YP_2377.
PATRICifig|214092.21.peg.2988.

Similar proteinsi

Entry informationi

Entry nameiACKA_YERPE
AccessioniPrimary (citable) accession number: Q8ZDJ6
Secondary accession number(s): Q0WDW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: March 1, 2002
Last modified: June 7, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families