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Q8ZDF8

- SYL_YERPE

UniProt

Q8ZDF8 - SYL_YERPE

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Yersinia pestis
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei622 – 6221ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYPES214092:GKDD-2576-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:YPO2610, y1184, YP_1103
    OrganismiYersinia pestis
    Taxonomic identifieri632 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 860860Leucine--tRNA ligasePRO_0000152124Add
    BLAST

    Proteomic databases

    PRIDEiQ8ZDF8.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8ZDF8. 3 interactions.
    STRINGi214092.YPO2610.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8ZDF8.
    SMRiQ8ZDF8. Positions 228-413.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi619 – 6235"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiMAFAGPP.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8ZDF8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQEQYRPEDI ETQVQLHWQE KQTFKVTEDA SKEKYYCLSM LPYPSGRLHM    50
    GHVRNYTIGD VISRYQRMLG KNVLQPIGWD AFGLPAEGAA VKNNTAPAPW 100
    TYDNIEYMKN QLKLLGFGYD WDREIATCKP DYYRWEQWFF TKLYEKGMVY 150
    KKTSAVNWCP HDLTVLANEQ VIDGCCWRCD TKVERKEIPQ WFIKITDYAE 200
    QLLNDLDTLE SWPEQVKTMQ RNWIGRSEGV DIVFDVVDSE EKLSVYTTRP 250
    DTFMGVTYVA VAAGHPLSLQ AAATNPALAD FVAECRNTKV AEAEMATMEK 300
    KGMATGLYAI HPLTGEKLPI WAANFVLMDY GTGAVMAVPG HDARDWEFAT 350
    KYNLPIKPVI LAADGSEPDL SQEAMTEKGT LFNSGEFDGL NHEDGFNAIA 400
    DKLVALGVGQ RKVNYRLRDW GVSRQRYWGA PIPMVTLEDG TVVPTPEDQL 450
    PVILPEDVVM DGISSPIKAD PEWAKTTVNG IPGLRETDTF DTFMESSWYY 500
    ARYTCPQYDD GMLDPAAANY WLPVDQYVGG IEHAIMHLMY FRFFHKLLRD 550
    AGLVDSDEPA KRLLCQGMVL ADAFYYTGNN GERIWVSPVD AIVERDDKGR 600
    IVKAVDAEGH ELVYAGMSKM SKSKNNGIDP QVMVEKYGAD TVRLFMMFAS 650
    PAEMTLEWQE SGVEGANRFL KRVWRLAFDH TAKGAVKPLD IASLTEEQKS 700
    LRRDLHKTIA KVTDDVGRRQ TFNTAIAAVM ELMNKLGRAP QETEQDRALM 750
    QEALLAVVRM LYPFTPHVCF SLWQALGGEG DIDTAPWPIA DEQAMVEDSK 800
    LVVVQVNGKV RGRITVPADA TEQQVRERAG QEHLVAKYLD GVTVRKVIYV 850
    PGKLLNLVVG 860
    Length:860
    Mass (Da):97,051
    Last modified:March 1, 2002 - v1
    Checksum:i34DA41D2A01FD153
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL21233.1.
    AE009952 Genomic DNA. Translation: AAM84761.1.
    AE017042 Genomic DNA. Translation: AAS61349.1.
    PIRiAF0318.
    RefSeqiNP_668510.1. NC_004088.1.
    NP_992472.1. NC_005810.1.
    YP_002347566.1. NC_003143.1.

    Genome annotation databases

    EnsemblBacteriaiAAM84761; AAM84761; y1184.
    AAS61349; AAS61349; YP_1103.
    GeneIDi1146131.
    1175439.
    2763450.
    KEGGiype:YPO2610.
    ypk:y1184.
    ypm:YP_1103.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL21233.1 .
    AE009952 Genomic DNA. Translation: AAM84761.1 .
    AE017042 Genomic DNA. Translation: AAS61349.1 .
    PIRi AF0318.
    RefSeqi NP_668510.1. NC_004088.1.
    NP_992472.1. NC_005810.1.
    YP_002347566.1. NC_003143.1.

    3D structure databases

    ProteinModelPortali Q8ZDF8.
    SMRi Q8ZDF8. Positions 228-413.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8ZDF8. 3 interactions.
    STRINGi 214092.YPO2610.

    Proteomic databases

    PRIDEi Q8ZDF8.

    Protocols and materials databases

    DNASUi 1146131.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM84761 ; AAM84761 ; y1184 .
    AAS61349 ; AAS61349 ; YP_1103 .
    GeneIDi 1146131.
    1175439.
    2763450.
    KEGGi ype:YPO2610.
    ypk:y1184.
    ypm:YP_1103.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi MAFAGPP.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci YPES214092:GKDD-2576-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CO-92 / Biovar Orientalis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIM10+ / Biovar Mediaevalis.
    3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
      Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
      , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
      DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 91001 / Biovar Mediaevalis.

    Entry informationi

    Entry nameiSYL_YERPE
    AccessioniPrimary (citable) accession number: Q8ZDF8
    Secondary accession number(s): Q0WDS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 28, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3