Q8ZD92 (CPDP_YERPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable 3',5'-cyclic-nucleotide phosphodiesterase
Short name=3':5'-CNP
Short name=PDEase
EC=3.1.4.17

Gene names

Name:	cpdP
Ordered Locus Names:	YPO2696, y1271, YP_2500

Organism

Yersinia pestis

Taxonomic identifier

632 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.
Subcellular location	Periplasm By similarity.
Sequence similarities	Belongs to the cAMP phosphodiesterase class-II family.
Sequence caution	The sequence AAM84845.1 differs from that shown. Reason: Erroneous initiation. The sequence AAS62699.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Signal
Ligand	cAMP
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cAMP catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3',5'-cyclic-AMP phosphodiesterase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 36	36	Potential
	Chain	37 – 343	307	Probable 3',5'-cyclic-nucleotide phosphodiesterase		PRO_0000023355

Sequences

	Sequence		Length	Mass (Da)
	Q8ZD92 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: B694C1AEA9C01F57	FASTA	343	37,874
	10 20 30 40 50 60 MKYLSIKSAS DKIKSGLLKT GVILSFSLFS SLSTAAFEVV ALGVDGGVSD GNLTSYLIRN 70 80 90 100 110 120 DSQPLYLGLD AGSVLPGIAR ALEKGHFAAI TDAMAAPLTR QGYIFRQSIN SYFISHAHLD 130 140 150 160 170 180 HVSGLIIGSP DDSKKTIYAS ADTIDVLRNY YFNWRVWPNF TDSGSGARLG TYRMQVVRPA 190 200 210 220 230 240 QSLSLGLTRL TGEMYPLSHD KSPSSMLLIS SNNEFFAYFG DTGPDDVEKS KNLDTVWRKL 250 260 270 280 290 300 AEKVTQQQLK GMIIEVSYPN DVADNKLFGH MTPTWLLKEL KKLEQYSGEG QPLKGLPVVI 310 320 330 340 SHIKPSFQQG QDVRKLILSE LQQGNDMGIE FILMEQGDSQ KFQ

References

[1]	"Genome sequence of Yersinia pestis, the causative agent of plague." Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:523-527(2001) [PubMed: 11586360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CO-92 / Biovar Orientalis.
[2]	"Genome sequence of Yersinia pestis KIM." Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. , Matson J.S., Blattner F.R., Perry R.D. J. Bacteriol. 184:4601-4611(2002) [PubMed: 12142430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KIM5 / Biovar Mediaevalis.
[3]	"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans." Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R. DNA Res. 11:179-197(2004) [PubMed: 15368893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL590842 Genomic DNA. Translation: CAL21315.1. AE009952 Genomic DNA. Translation: AAM84845.1. Different initiation. AE017042 Genomic DNA. Translation: AAS62699.1. Different initiation.
PIR	AH0328.
RefSeq	NP_668594.1. NC_004088.1. NP_993822.1. NC_005810.1. YP_002347644.1. NC_003143.1.
3D structure databases
ProteinModelPortal	Q8ZD92.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1146218. 1175526. 2764764.
GenomeReviews	Gene locus y1271 in contig AE009952_GR. Gene locus YP_2500 in contig AE017042_GR. Gene locus YPO2696 in contig AL590842_GR.
KEGG	ype:YPO2696. ypk:y1271. ypm:YP_2500.
Phylogenomic databases
HOGENOM	HBG303327.
OMA	LYFGDTG.
ProtClustDB	CLSK889264.
Enzyme and pathway databases
BioCyc	YPES187410:Y1271-MONOMER. YPES214092:YPO2696-MONOMER.
Family and domain databases
InterPro	IPR024225. cAMP-PdiesteraseII_CS. IPR000396. Pdiesterase2. [Graphical view]
KO	K01120.
Pfam	PF02112. PDEase_II. 1 hit. [Graphical view]
PIRSF	PIRSF000962. Cyc_nuc_PDEase. 1 hit.
PRINTS	PR00388. PDIESTERASE2.
PROSITE	PS00607. PDEASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CPDP_YERPE

Accession

Primary (citable) accession number: Q8ZD92
Secondary accession number(s): Q0WDJ4, Q8CLI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
Last sequence update:	March 1, 2002
Last modified:	November 16, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program