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Protein

Probable 3',5'-cyclic-nucleotide phosphodiesterase

Gene

cpdP

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: InterPro

GO - Biological processi

  1. cAMP catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP

Enzyme and pathway databases

BioCyciYPES214092:GKDD-2663-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 3',5'-cyclic-nucleotide phosphodiesterase (EC:3.1.4.17)
Short name:
3':5'-CNP
Short name:
PDEase
Gene namesi
Name:cpdP
Ordered Locus Names:YPO2696, y1271, YP_2500
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

Subcellular locationi

Periplasm By similarity

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3636Sequence AnalysisAdd
BLAST
Chaini37 – 343307Probable 3',5'-cyclic-nucleotide phosphodiesterasePRO_0000023355Add
BLAST

Proteomic databases

PRIDEiQ8ZD92.

Interactioni

Protein-protein interaction databases

STRINGi214092.YPO2696.

Structurei

3D structure databases

ProteinModelPortaliQ8ZD92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5212.
HOGENOMiHOG000219486.
KOiK01120.
OMAiFNWSAWP.
OrthoDBiEOG67T5G8.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Beta-lactamas-like.
IPR024225. cAMP-PdiesteraseII_CS.
IPR000396. Pdiesterase2.
[Graphical view]
PfamiPF02112. PDEase_II. 1 hit.
[Graphical view]
PIRSFiPIRSF000962. Cyc_nuc_PDEase. 1 hit.
PRINTSiPR00388. PDIESTERASE2.
SUPFAMiSSF56281. SSF56281. 1 hit.
PROSITEiPS00607. PDEASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8ZD92-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKYLSIKSAS DKIKSGLLKT GVILSFSLFS SLSTAAFEVV ALGVDGGVSD
60 70 80 90 100
GNLTSYLIRN DSQPLYLGLD AGSVLPGIAR ALEKGHFAAI TDAMAAPLTR
110 120 130 140 150
QGYIFRQSIN SYFISHAHLD HVSGLIIGSP DDSKKTIYAS ADTIDVLRNY
160 170 180 190 200
YFNWRVWPNF TDSGSGARLG TYRMQVVRPA QSLSLGLTRL TGEMYPLSHD
210 220 230 240 250
KSPSSMLLIS SNNEFFAYFG DTGPDDVEKS KNLDTVWRKL AEKVTQQQLK
260 270 280 290 300
GMIIEVSYPN DVADNKLFGH MTPTWLLKEL KKLEQYSGEG QPLKGLPVVI
310 320 330 340
SHIKPSFQQG QDVRKLILSE LQQGNDMGIE FILMEQGDSQ KFQ
Length:343
Mass (Da):37,874
Last modified:March 1, 2002 - v1
Checksum:iB694C1AEA9C01F57
GO

Sequence cautioni

The sequence AAM84845.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAS62699.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL21315.1.
AE009952 Genomic DNA. Translation: AAM84845.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS62699.1. Different initiation.
PIRiAH0328.
RefSeqiNP_668594.1. NC_004088.1.
NP_993822.1. NC_005810.1.
YP_002347644.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM84845; AAM84845; y1271.
AAS62699; AAS62699; YP_2500.
GeneIDi1146218.
1175526.
2764764.
KEGGiype:YPO2696.
ypk:y1271.
ypm:YP_2500.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL21315.1.
AE009952 Genomic DNA. Translation: AAM84845.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS62699.1. Different initiation.
PIRiAH0328.
RefSeqiNP_668594.1. NC_004088.1.
NP_993822.1. NC_005810.1.
YP_002347644.1. NC_003143.1.

3D structure databases

ProteinModelPortaliQ8ZD92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi214092.YPO2696.

Proteomic databases

PRIDEiQ8ZD92.

Protocols and materials databases

DNASUi1146218.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM84845; AAM84845; y1271.
AAS62699; AAS62699; YP_2500.
GeneIDi1146218.
1175526.
2764764.
KEGGiype:YPO2696.
ypk:y1271.
ypm:YP_2500.

Phylogenomic databases

eggNOGiCOG5212.
HOGENOMiHOG000219486.
KOiK01120.
OMAiFNWSAWP.
OrthoDBiEOG67T5G8.

Enzyme and pathway databases

BioCyciYPES214092:GKDD-2663-MONOMER.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Beta-lactamas-like.
IPR024225. cAMP-PdiesteraseII_CS.
IPR000396. Pdiesterase2.
[Graphical view]
PfamiPF02112. PDEase_II. 1 hit.
[Graphical view]
PIRSFiPIRSF000962. Cyc_nuc_PDEase. 1 hit.
PRINTSiPR00388. PDIESTERASE2.
SUPFAMiSSF56281. SSF56281. 1 hit.
PROSITEiPS00607. PDEASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiCPDP_YERPE
AccessioniPrimary (citable) accession number: Q8ZD92
Secondary accession number(s): Q0WDJ4, Q8CLI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2002
Last modified: January 7, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.