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Q8ZD80

- NADB_YERPE

UniProt

Q8ZD80 - NADB_YERPE

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Protein

L-aspartate oxidase

Gene

nadB

Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidation of L-aspartate to iminoaspartate.

Catalytic activityi

L-aspartate + O2 = iminosuccinate + H2O2.

Cofactori

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei244 – 2441By similarity
Active sitei263 – 2631By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 2615FADSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. L-aspartate:fumarate oxidoreductase activity Source: UniProtKB-EC
  2. L-aspartate oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciYPES214092:GKDD-2677-MONOMER.
UniPathwayiUPA00253; UER00326.

Names & Taxonomyi

Protein namesi
Recommended name:
L-aspartate oxidase (EC:1.4.3.16)
Short name:
LASPO
Alternative name(s):
Quinolinate synthase B
Gene namesi
Name:nadB
Ordered Locus Names:YPO2710, y1289, YP_2514
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 533533L-aspartate oxidasePRO_0000184406Add
BLAST

Proteomic databases

PRIDEiQ8ZD80.

Interactioni

Protein-protein interaction databases

STRINGi214092.YPO2710.

Structurei

3D structure databases

ProteinModelPortaliQ8ZD80.
SMRiQ8ZD80. Positions 6-533.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0029.
HOGENOMiHOG000160476.
KOiK00278.
OMAiEINEYYW.
OrthoDBiEOG696BWH.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR005288. NadB.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PRINTSiPR00368. FADPNR.
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR00551. nadB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZD80-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQSSSEHISD VLIIGSGAAG LSLALRLAPH CKVTVLSKGP LNEGATFYAQ
60 70 80 90 100
GGIAAVFDET DSISSHVDDT LIAGAGLCDK EAVEFIASNA RSCVQWLIDQ
110 120 130 140 150
GVLFDTETSA NGEERYHLTR EGGHSHRRIL HTADATGKEV ETTLVGKASN
160 170 180 190 200
HPNISVKERC NAVDLITSNK IGLAGTKRVV GAYVWNRELE KVETFRAKAV
210 220 230 240 250
VLATGGAAKV YQYTTNPDIS SGDGIAMAWR AGCRVANLEF NQFHPTCLFH
260 270 280 290 300
PQARNFLLTE ALRGEGAYLK RPDGSRFMLD FDPRGELAPR DIVARAIDHE
310 320 330 340 350
MKRLGADCMY LDISHKPTDF VMQHFPMIYE KLLSLGIDLT KEAIPIVPAA
360 370 380 390 400
HYTCGGVMVD QHGRTDLDGL YAIGEVSYTG LHGANRMASN SLLECLVYGW
410 420 430 440 450
SAAEDILTRL PTAKLAKHLP DWDESRVDNS DERVVIQHNW HELRLFMWDY
460 470 480 490 500
VGIVRTTKRL ERALRRINTL QQEIDEYYAN FRISNNLLEL RNLVQVAELI
510 520 530
VRCAMERKES RGLHYTLDYP DQIENPQPTI LHP
Length:533
Mass (Da):59,294
Last modified:August 30, 2002 - v2
Checksum:i909E8BFEB15BD2BD
GO

Sequence cautioni

The sequence AAM84863.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAS62712.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAL21329.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL21329.1. Different initiation.
AE009952 Genomic DNA. Translation: AAM84863.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS62712.1. Different initiation.
PIRiAF0330.
RefSeqiNP_668612.1. NC_004088.1.
NP_993835.1. NC_005810.1.
YP_002347657.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM84863; AAM84863; y1289.
AAS62712; AAS62712; YP_2514.
GeneIDi1146236.
1175540.
2764388.
KEGGiype:YPO2710.
ypk:y1289.
ypm:YP_2514.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL21329.1 . Different initiation.
AE009952 Genomic DNA. Translation: AAM84863.1 . Different initiation.
AE017042 Genomic DNA. Translation: AAS62712.1 . Different initiation.
PIRi AF0330.
RefSeqi NP_668612.1. NC_004088.1.
NP_993835.1. NC_005810.1.
YP_002347657.1. NC_003143.1.

3D structure databases

ProteinModelPortali Q8ZD80.
SMRi Q8ZD80. Positions 6-533.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 214092.YPO2710.

Proteomic databases

PRIDEi Q8ZD80.

Protocols and materials databases

DNASUi 1146236.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM84863 ; AAM84863 ; y1289 .
AAS62712 ; AAS62712 ; YP_2514 .
GeneIDi 1146236.
1175540.
2764388.
KEGGi ype:YPO2710.
ypk:y1289.
ypm:YP_2514.

Phylogenomic databases

eggNOGi COG0029.
HOGENOMi HOG000160476.
KOi K00278.
OMAi EINEYYW.
OrthoDBi EOG696BWH.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00326 .
BioCyci YPES214092:GKDD-2677-MONOMER.

Family and domain databases

Gene3Di 1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProi IPR003953. FAD_bind_dom.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR005288. NadB.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
[Graphical view ]
Pfami PF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view ]
PRINTSi PR00368. FADPNR.
SUPFAMi SSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsi TIGR00551. nadB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiNADB_YERPE
AccessioniPrimary (citable) accession number: Q8ZD80
Secondary accession number(s): Q0WDI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 30, 2002
Last modified: November 26, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3