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Protein

L-aspartate oxidase

Gene

nadB

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidation of L-aspartate to iminoaspartate.

Catalytic activityi

L-aspartate + O2 = iminosuccinate + H2O2.

Cofactori

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes iminoaspartate from L-aspartate (oxidase route).
Proteins known to be involved in this subpathway in this organism are:
  1. L-aspartate oxidase (nadB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes iminoaspartate from L-aspartate (oxidase route), the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei244By similarity1
Active sitei263By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 26FADSequence analysisAdd BLAST15

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPyridine nucleotide biosynthesis
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00253; UER00326

Names & Taxonomyi

Protein namesi
Recommended name:
L-aspartate oxidase (EC:1.4.3.16)
Short name:
LASPO
Alternative name(s):
Quinolinate synthase B
Gene namesi
Name:nadB
Ordered Locus Names:YPO2710, y1289, YP_2514
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001844061 – 533L-aspartate oxidaseAdd BLAST533

Proteomic databases

PaxDbiQ8ZD80

Interactioni

Protein-protein interaction databases

STRINGi187410.y1289

Structurei

3D structure databases

ProteinModelPortaliQ8ZD80
SMRiQ8ZD80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108IYU Bacteria
COG0029 LUCA
HOGENOMiHOG000160476
KOiK00278
OMAiHCVQWLI

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR005288 NadB
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
PANTHERiPTHR42716:SF2 PTHR42716:SF2, 1 hit
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR00551 nadB, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZD80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSSSEHISD VLIIGSGAAG LSLALRLAPH CKVTVLSKGP LNEGATFYAQ
60 70 80 90 100
GGIAAVFDET DSISSHVDDT LIAGAGLCDK EAVEFIASNA RSCVQWLIDQ
110 120 130 140 150
GVLFDTETSA NGEERYHLTR EGGHSHRRIL HTADATGKEV ETTLVGKASN
160 170 180 190 200
HPNISVKERC NAVDLITSNK IGLAGTKRVV GAYVWNRELE KVETFRAKAV
210 220 230 240 250
VLATGGAAKV YQYTTNPDIS SGDGIAMAWR AGCRVANLEF NQFHPTCLFH
260 270 280 290 300
PQARNFLLTE ALRGEGAYLK RPDGSRFMLD FDPRGELAPR DIVARAIDHE
310 320 330 340 350
MKRLGADCMY LDISHKPTDF VMQHFPMIYE KLLSLGIDLT KEAIPIVPAA
360 370 380 390 400
HYTCGGVMVD QHGRTDLDGL YAIGEVSYTG LHGANRMASN SLLECLVYGW
410 420 430 440 450
SAAEDILTRL PTAKLAKHLP DWDESRVDNS DERVVIQHNW HELRLFMWDY
460 470 480 490 500
VGIVRTTKRL ERALRRINTL QQEIDEYYAN FRISNNLLEL RNLVQVAELI
510 520 530
VRCAMERKES RGLHYTLDYP DQIENPQPTI LHP
Length:533
Mass (Da):59,294
Last modified:August 30, 2002 - v2
Checksum:i909E8BFEB15BD2BD
GO

Sequence cautioni

The sequence AAM84863 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAS62712 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAL21329 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL21329.1 Different initiation.
AE009952 Genomic DNA Translation: AAM84863.1 Different initiation.
AE017042 Genomic DNA Translation: AAS62712.1 Different initiation.
PIRiAF0330
RefSeqiYP_002347657.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM84863; AAM84863; y1289
AAS62712; AAS62712; YP_2514
GeneIDi1175540
KEGGiype:YPO2710
ypj:CH55_1456
ypk:y1289
ypl:CH46_2394
ypm:YP_2514
ypv:BZ15_818
ypw:CH59_3595
PATRICifig|214092.21.peg.3151

Similar proteinsi

Entry informationi

Entry nameiNADB_YERPE
AccessioniPrimary (citable) accession number: Q8ZD80
Secondary accession number(s): Q0WDI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 30, 2002
Last modified: May 23, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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