Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8ZCX8

- PUR5_YERPE

UniProt

Q8ZCX8 - PUR5_YERPE

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYPES214092:GKDD-2792-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Synonyms:purI
    Ordered Locus Names:YPO2828, y1407, YP_2696
    OrganismiYersinia pestis
    Taxonomic identifieri632 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000148278Add
    BLAST

    Proteomic databases

    PRIDEiQ8ZCX8.

    Interactioni

    Protein-protein interaction databases

    STRINGi214092.YPO2828.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8ZCX8.
    SMRiQ8ZCX8. Positions 5-345.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229090.
    KOiK01933.
    OMAiEFEMYRT.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8ZCX8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNKTSLSYK DAGVDIDAGN DLVDRIKGVV KQTRRPEVMG GLGGFGALCA    50
    LPQKYREPIL VSGTDGVGTK LRLAMDLKRH DTIGIDLVAM CVNDLVVQGA 100
    EPLFFLDYFA TGKLDVDTAA SVITGIAEGC KQSGCALVGG ETAEMPGMYH 150
    GDDYDVAGFC VGVVEKSEII DGSKVTPGDV LVALGASGPH SNGYSLVRKI 200
    LDVSNTNPEQ TSLEGKSLAD HLLEPTKIYV KSILSLIEQL DIHAIAHLTG 250
    GGFWENIPRV LPQGMQAVID EASWQWPAVF SWLQQAGNVS RHEMYRTFNC 300
    GVGMVVALPA ELADKAVELL TASGEKAWKI GVIAAATEGA EQVIINP 347
    Length:347
    Mass (Da):36,854
    Last modified:March 1, 2002 - v1
    Checksum:iC24FFB51B2BC0998
    GO

    Sequence cautioni

    The sequence AAS62886.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL21441.1.
    AE009952 Genomic DNA. Translation: AAM84979.1.
    AE017042 Genomic DNA. Translation: AAS62886.1. Different initiation.
    PIRiAF0344.
    RefSeqiNP_668728.1. NC_004088.1.
    YP_002347768.1. NC_003143.1.

    Genome annotation databases

    EnsemblBacteriaiAAM84979; AAM84979; y1407.
    AAS62886; AAS62886; YP_2696.
    GeneIDi1146354.
    1175654.
    KEGGiype:YPO2828.
    ypk:y1407.
    PATRICi18595486. VBIYerPes7843_3445.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL21441.1 .
    AE009952 Genomic DNA. Translation: AAM84979.1 .
    AE017042 Genomic DNA. Translation: AAS62886.1 . Different initiation.
    PIRi AF0344.
    RefSeqi NP_668728.1. NC_004088.1.
    YP_002347768.1. NC_003143.1.

    3D structure databases

    ProteinModelPortali Q8ZCX8.
    SMRi Q8ZCX8. Positions 5-345.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 214092.YPO2828.

    Proteomic databases

    PRIDEi Q8ZCX8.

    Protocols and materials databases

    DNASUi 1146354.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM84979 ; AAM84979 ; y1407 .
    AAS62886 ; AAS62886 ; YP_2696 .
    GeneIDi 1146354.
    1175654.
    KEGGi ype:YPO2828.
    ypk:y1407.
    PATRICi 18595486. VBIYerPes7843_3445.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229090.
    KOi K01933.
    OMAi EFEMYRT.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci YPES214092:GKDD-2792-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CO-92 / Biovar Orientalis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIM10+ / Biovar Mediaevalis.
    3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
      Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
      , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
      DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 91001 / Biovar Mediaevalis.

    Entry informationi

    Entry nameiPUR5_YERPE
    AccessioniPrimary (citable) accession number: Q8ZCX8
    Secondary accession number(s): Q0WD70
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3