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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase (purL)
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Synonyms:purI
Ordered Locus Names:YPO2828, y1407, YP_2696
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001482781 – 347Phosphoribosylformylglycinamidine cyclo-ligaseAdd BLAST347

Proteomic databases

PaxDbiQ8ZCX8
PRIDEiQ8ZCX8

Interactioni

Protein-protein interaction databases

STRINGi187410.y1407

Structurei

3D structure databases

ProteinModelPortaliQ8ZCX8
SMRiQ8ZCX8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXB Bacteria
COG0150 LUCA
HOGENOMiHOG000229090
KOiK01933
OMAiNHCVNDI

Family and domain databases

CDDicd02196 PurM, 1 hit
Gene3Di3.30.1330.10, 1 hit
3.90.650.10, 1 hit
HAMAPiMF_00741 AIRS, 1 hit
InterProiView protein in InterPro
IPR010918 PurM-like_C_dom
IPR036676 PurM-like_C_sf
IPR016188 PurM-like_N
IPR036921 PurM-like_N_sf
IPR004733 PurM_cligase
PANTHERiPTHR10520 PTHR10520, 1 hit
PfamiView protein in Pfam
PF00586 AIRS, 1 hit
PF02769 AIRS_C, 1 hit
SUPFAMiSSF55326 SSF55326, 1 hit
SSF56042 SSF56042, 1 hit
TIGRFAMsiTIGR00878 purM, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZCX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNKTSLSYK DAGVDIDAGN DLVDRIKGVV KQTRRPEVMG GLGGFGALCA
60 70 80 90 100
LPQKYREPIL VSGTDGVGTK LRLAMDLKRH DTIGIDLVAM CVNDLVVQGA
110 120 130 140 150
EPLFFLDYFA TGKLDVDTAA SVITGIAEGC KQSGCALVGG ETAEMPGMYH
160 170 180 190 200
GDDYDVAGFC VGVVEKSEII DGSKVTPGDV LVALGASGPH SNGYSLVRKI
210 220 230 240 250
LDVSNTNPEQ TSLEGKSLAD HLLEPTKIYV KSILSLIEQL DIHAIAHLTG
260 270 280 290 300
GGFWENIPRV LPQGMQAVID EASWQWPAVF SWLQQAGNVS RHEMYRTFNC
310 320 330 340
GVGMVVALPA ELADKAVELL TASGEKAWKI GVIAAATEGA EQVIINP
Length:347
Mass (Da):36,854
Last modified:March 1, 2002 - v1
Checksum:iC24FFB51B2BC0998
GO

Sequence cautioni

The sequence AAS62886 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL21441.1
AE009952 Genomic DNA Translation: AAM84979.1
AE017042 Genomic DNA Translation: AAS62886.1 Different initiation.
PIRiAF0344
RefSeqiWP_002209777.1, NZ_PDBR01000039.1
YP_002347768.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM84979; AAM84979; y1407
AAS62886; AAS62886; YP_2696
GeneIDi1175654
KEGGiype:YPO2828
ypk:y1407
ypm:YP_2696
PATRICifig|214092.21.peg.3272

Similar proteinsi

Entry informationi

Entry nameiPUR5_YERPE
AccessioniPrimary (citable) accession number: Q8ZCX8
Secondary accession number(s): Q0WD70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health