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Protein

Multidrug resistance protein MdtB

Gene

mdtB

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtBUniRule annotation
Alternative name(s):
Multidrug transporter MdtBUniRule annotation
Gene namesi
Name:mdtBUniRule annotation
Ordered Locus Names:YPO2848, y1385, YP_2715
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 37HelicalUniRule annotationAdd BLAST23
Transmembranei345 – 362HelicalUniRule annotationAdd BLAST18
Transmembranei367 – 389HelicalUniRule annotationAdd BLAST23
Transmembranei396 – 418HelicalUniRule annotationAdd BLAST23
Transmembranei438 – 460HelicalUniRule annotationAdd BLAST23
Transmembranei472 – 494HelicalUniRule annotationAdd BLAST23
Transmembranei535 – 557HelicalUniRule annotationAdd BLAST23
Transmembranei867 – 889HelicalUniRule annotationAdd BLAST23
Transmembranei909 – 931HelicalUniRule annotationAdd BLAST23
Transmembranei968 – 990HelicalUniRule annotationAdd BLAST23
Transmembranei1000 – 1022HelicalUniRule annotationAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001618291 – 1052Multidrug resistance protein MdtBAdd BLAST1052

Proteomic databases

PaxDbiQ8ZCW0

Interactioni

Subunit structurei

Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtB forms a heteromultimer with MdtC.UniRule annotation

Protein-protein interaction databases

IntActiQ8ZCW0, 12 interactors
STRINGi187410.y1385

Structurei

3D structure databases

ProteinModelPortaliQ8ZCW0
SMRiQ8ZCW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZS Bacteria
COG0841 LUCA
HOGENOMiHOG000158127
KOiK07788
OMAiMNGKQYQ

Family and domain databases

Gene3Di3.30.2090.10, 2 hits
HAMAPiMF_01423 MdtB, 1 hit
InterProiView protein in InterPro
IPR027463 AcrB_DN_DC_subdom
IPR001036 Acrflvin-R
IPR022831 Multidrug-R_MdtB
PANTHERiPTHR32063 PTHR32063, 1 hit
PfamiView protein in Pfam
PF00873 ACR_tran, 1 hit
PRINTSiPR00702 ACRIFLAVINRP
SUPFAMiSSF82714 SSF82714, 2 hits

Sequencei

Sequence statusi: Complete.

Q8ZCW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVMPPTPGG GPSRLFILRP VATTLFMIAI LLAGIIGYRA LPVSALPEVD
60 70 80 90 100
YPTIQVVTLY PGASPDVVTS SITAPLERQF GQMSGLKQMA SQSSGGASVI
110 120 130 140 150
TLQFQLTLPL DVAEQEVQAA INAATNLLPS DLPYPPIYNK VNPADPPILT
160 170 180 190 200
LAVTATAIPM TQVEDMVETR IAQKISQVTG VGLVTLSGGQ RPAVRVKLNA
210 220 230 240 250
PAVAALGLDS ETIRTAISNA NVNSAKGSLD GPTRSVTLSA NDQMKSAEEY
260 270 280 290 300
RDLIIAYQNG APIRLQDVAT IEQGAENNKL AAWANTQSAI VLNIQRQPGV
310 320 330 340 350
NVIATADSIR EMLPELIKSL PKSVDVKVLT DRTSTIRASV NDVQFELLLA
360 370 380 390 400
IALVVMVIYL FLRNAAATII PSIAVPLSLV GTFAAMYFLG FSINNLTLMA
410 420 430 440 450
LTIATGFVVD DAIVVIENIS RYIEKGEKPL DAALKGAGEI GFTIISLTFS
460 470 480 490 500
LIAVLIPLLF MEDIVGRLFR EFAVTLAVAI LISAVVSLTL TPMMCARMLS
510 520 530 540 550
YESLRKQNRL SRASEKFFDW VIAHYAVALK KVLNHPWLTL SVAFSTLVLT
560 570 580 590 600
VILYLLIPKG FFPLQDNGLI QGTLEAPQSV SFSNMAERQQ QVAAIILKDP
610 620 630 640 650
AVESLTSFVG VDGTNATLNN GRLQINLKPL SERDDRIPQI ITRLQESVSG
660 670 680 690 700
VPGIKLYLQP VQDLTIDTQL SRTQYQFTLQ ATSLEELSTW VPKLVNELQQ
710 720 730 740 750
KAPFQDVTSD WQDQGLVAFV NVDRDSASRL GITMAAIDNA LYNAFGQRLI
760 770 780 790 800
STIYTQSNQY RVVLEHDVQA TPGLAAFNDI RLTGIDGKGV PLSSIATIEE
810 820 830 840 850
RFGPLSINHL NQFPSATVSF NLAQGYSLGE AVAAVTLAEK EIQLPADITT
860 870 880 890 900
RFQGSTLAFQ AALGSTLWLI IAAIVAMYIV LGVLYESFIH PITILSTLPT
910 920 930 940 950
AGVGALLALM LTGNELDVIA IIGIILLIGI VKKNAIMMID FALAAERDQG
960 970 980 990 1000
MTPYDAIYQA CLLRFRPILM TTLAALFGAL PLMLSTGVGA ELRQPLGVCM
1010 1020 1030 1040 1050
VGGLIVSQVL TLFTTPVIYL LFDKLARNTR GKNRHRDEDI DSSELLNGQE

PQ
Length:1,052
Mass (Da):113,533
Last modified:March 1, 2002 - v1
Checksum:iFFC2D74E485E2B61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL21460.1
AE009952 Genomic DNA Translation: AAM84957.1
AE017042 Genomic DNA Translation: AAS62904.1
PIRiAI0346
RefSeqiWP_002209793.1, NZ_PDBR01000039.1
YP_002347786.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM84957; AAM84957; y1385
AAS62904; AAS62904; YP_2715
GeneIDi1175673
KEGGiype:YPO2848
ypj:CH55_3971
ypk:y1385
ypl:CH46_2255
ypm:YP_2715
ypv:BZ15_682
ypw:CH59_3224
PATRICifig|214092.21.peg.3292

Similar proteinsi

Entry informationi

Entry nameiMDTB_YERPE
AccessioniPrimary (citable) accession number: Q8ZCW0
Secondary accession number(s): Q0WD52, Q74SA7, Q7CJK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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