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Protein

Multidrug resistance protein MdtB

Gene

mdtB

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYPES214092:GKDD-2811-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtBUniRule annotation
Alternative name(s):
Multidrug transporter MdtBUniRule annotation
Gene namesi
Name:mdtBUniRule annotation
Ordered Locus Names:YPO2848, y1385, YP_2715
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3723HelicalUniRule annotationAdd
BLAST
Transmembranei345 – 36218HelicalUniRule annotationAdd
BLAST
Transmembranei367 – 38923HelicalUniRule annotationAdd
BLAST
Transmembranei396 – 41823HelicalUniRule annotationAdd
BLAST
Transmembranei438 – 46023HelicalUniRule annotationAdd
BLAST
Transmembranei472 – 49423HelicalUniRule annotationAdd
BLAST
Transmembranei535 – 55723HelicalUniRule annotationAdd
BLAST
Transmembranei867 – 88923HelicalUniRule annotationAdd
BLAST
Transmembranei909 – 93123HelicalUniRule annotationAdd
BLAST
Transmembranei968 – 99023HelicalUniRule annotationAdd
BLAST
Transmembranei1000 – 102223HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10521052Multidrug resistance protein MdtBPRO_0000161829Add
BLAST

Interactioni

Subunit structurei

Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtB forms a heteromultimer with MdtC.UniRule annotation

Protein-protein interaction databases

IntActiQ8ZCW0. 12 interactions.
STRINGi187410.y1385.

Structurei

3D structure databases

ProteinModelPortaliQ8ZCW0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZS. Bacteria.
COG0841. LUCA.
HOGENOMiHOG000158127.
KOiK07788.
OMAiVPMMCAK.
OrthoDBiEOG6SFP62.

Family and domain databases

Gene3Di3.30.2090.10. 2 hits.
HAMAPiMF_01423. MdtB.
InterProiIPR027463. AcrB_DN_DC_subdom.
IPR001036. Acrflvin-R.
IPR022831. Multidrug-R_MdtB.
[Graphical view]
PfamiPF00873. ACR_tran. 1 hit.
[Graphical view]
PRINTSiPR00702. ACRIFLAVINRP.
SUPFAMiSSF82714. SSF82714. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8ZCW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVMPPTPGG GPSRLFILRP VATTLFMIAI LLAGIIGYRA LPVSALPEVD
60 70 80 90 100
YPTIQVVTLY PGASPDVVTS SITAPLERQF GQMSGLKQMA SQSSGGASVI
110 120 130 140 150
TLQFQLTLPL DVAEQEVQAA INAATNLLPS DLPYPPIYNK VNPADPPILT
160 170 180 190 200
LAVTATAIPM TQVEDMVETR IAQKISQVTG VGLVTLSGGQ RPAVRVKLNA
210 220 230 240 250
PAVAALGLDS ETIRTAISNA NVNSAKGSLD GPTRSVTLSA NDQMKSAEEY
260 270 280 290 300
RDLIIAYQNG APIRLQDVAT IEQGAENNKL AAWANTQSAI VLNIQRQPGV
310 320 330 340 350
NVIATADSIR EMLPELIKSL PKSVDVKVLT DRTSTIRASV NDVQFELLLA
360 370 380 390 400
IALVVMVIYL FLRNAAATII PSIAVPLSLV GTFAAMYFLG FSINNLTLMA
410 420 430 440 450
LTIATGFVVD DAIVVIENIS RYIEKGEKPL DAALKGAGEI GFTIISLTFS
460 470 480 490 500
LIAVLIPLLF MEDIVGRLFR EFAVTLAVAI LISAVVSLTL TPMMCARMLS
510 520 530 540 550
YESLRKQNRL SRASEKFFDW VIAHYAVALK KVLNHPWLTL SVAFSTLVLT
560 570 580 590 600
VILYLLIPKG FFPLQDNGLI QGTLEAPQSV SFSNMAERQQ QVAAIILKDP
610 620 630 640 650
AVESLTSFVG VDGTNATLNN GRLQINLKPL SERDDRIPQI ITRLQESVSG
660 670 680 690 700
VPGIKLYLQP VQDLTIDTQL SRTQYQFTLQ ATSLEELSTW VPKLVNELQQ
710 720 730 740 750
KAPFQDVTSD WQDQGLVAFV NVDRDSASRL GITMAAIDNA LYNAFGQRLI
760 770 780 790 800
STIYTQSNQY RVVLEHDVQA TPGLAAFNDI RLTGIDGKGV PLSSIATIEE
810 820 830 840 850
RFGPLSINHL NQFPSATVSF NLAQGYSLGE AVAAVTLAEK EIQLPADITT
860 870 880 890 900
RFQGSTLAFQ AALGSTLWLI IAAIVAMYIV LGVLYESFIH PITILSTLPT
910 920 930 940 950
AGVGALLALM LTGNELDVIA IIGIILLIGI VKKNAIMMID FALAAERDQG
960 970 980 990 1000
MTPYDAIYQA CLLRFRPILM TTLAALFGAL PLMLSTGVGA ELRQPLGVCM
1010 1020 1030 1040 1050
VGGLIVSQVL TLFTTPVIYL LFDKLARNTR GKNRHRDEDI DSSELLNGQE

PQ
Length:1,052
Mass (Da):113,533
Last modified:March 1, 2002 - v1
Checksum:iFFC2D74E485E2B61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL21460.1.
AE009952 Genomic DNA. Translation: AAM84957.1.
AE017042 Genomic DNA. Translation: AAS62904.1.
PIRiAI0346.
RefSeqiWP_002209793.1. NZ_LIXY01000015.1.
YP_002347786.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM84957; AAM84957; y1385.
AAS62904; AAS62904; YP_2715.
GeneIDi1175673.
KEGGiype:YPO2848.
ypj:CH55_3971.
ypk:y1385.
ypl:CH46_2255.
ypm:YP_2715.
ypv:BZ15_682.
ypw:CH59_3224.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL21460.1.
AE009952 Genomic DNA. Translation: AAM84957.1.
AE017042 Genomic DNA. Translation: AAS62904.1.
PIRiAI0346.
RefSeqiWP_002209793.1. NZ_LIXY01000015.1.
YP_002347786.1. NC_003143.1.

3D structure databases

ProteinModelPortaliQ8ZCW0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8ZCW0. 12 interactions.
STRINGi187410.y1385.

Protocols and materials databases

DNASUi1146332.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM84957; AAM84957; y1385.
AAS62904; AAS62904; YP_2715.
GeneIDi1175673.
KEGGiype:YPO2848.
ypj:CH55_3971.
ypk:y1385.
ypl:CH46_2255.
ypm:YP_2715.
ypv:BZ15_682.
ypw:CH59_3224.

Phylogenomic databases

eggNOGiENOG4105BZS. Bacteria.
COG0841. LUCA.
HOGENOMiHOG000158127.
KOiK07788.
OMAiVPMMCAK.
OrthoDBiEOG6SFP62.

Enzyme and pathway databases

BioCyciYPES214092:GKDD-2811-MONOMER.

Family and domain databases

Gene3Di3.30.2090.10. 2 hits.
HAMAPiMF_01423. MdtB.
InterProiIPR027463. AcrB_DN_DC_subdom.
IPR001036. Acrflvin-R.
IPR022831. Multidrug-R_MdtB.
[Graphical view]
PfamiPF00873. ACR_tran. 1 hit.
[Graphical view]
PRINTSiPR00702. ACRIFLAVINRP.
SUPFAMiSSF82714. SSF82714. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiMDTB_YERPE
AccessioniPrimary (citable) accession number: Q8ZCW0
Secondary accession number(s): Q0WD52, Q74SA7, Q7CJK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.