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Protein

Multidrug resistance protein MdtC

Gene

mdtC

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYPES214092:GKDD-2812-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtCUniRule annotation
Alternative name(s):
Multidrug transporter MdtCUniRule annotation
Gene namesi
Name:mdtCUniRule annotation
Ordered Locus Names:YPO2849, y1384, YP_2716
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3423HelicalUniRule annotationAdd
BLAST
Transmembranei336 – 35318HelicalUniRule annotationAdd
BLAST
Transmembranei360 – 37920HelicalUniRule annotationAdd
BLAST
Transmembranei389 – 41123HelicalUniRule annotationAdd
BLAST
Transmembranei431 – 45323HelicalUniRule annotationAdd
BLAST
Transmembranei468 – 49023HelicalUniRule annotationAdd
BLAST
Transmembranei853 – 87523HelicalUniRule annotationAdd
BLAST
Transmembranei895 – 91723HelicalUniRule annotationAdd
BLAST
Transmembranei948 – 97023HelicalUniRule annotationAdd
BLAST
Transmembranei985 – 100723HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10241024Multidrug resistance protein MdtCPRO_0000161839Add
BLAST

Interactioni

Subunit structurei

Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtC forms a heteromultimer with MdtB.UniRule annotation

Protein-protein interaction databases

IntActiQ8ZCV9. 4 interactions.
STRINGi187410.y1384.

Structurei

3D structure databases

ProteinModelPortaliQ8ZCV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtC subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZS. Bacteria.
COG0841. LUCA.
HOGENOMiHOG000158127.
KOiK07789.
OMAiMFVINSD.
OrthoDBiEOG6SFP62.

Family and domain databases

Gene3Di3.30.2090.10. 2 hits.
HAMAPiMF_01424. MdtC.
InterProiIPR027463. AcrB_DN_DC_subdom.
IPR001036. Acrflvin-R.
IPR023931. Multidrug-R_MdtC.
[Graphical view]
PfamiPF00873. ACR_tran. 1 hit.
[Graphical view]
PRINTSiPR00702. ACRIFLAVINRP.
SUPFAMiSSF82714. SSF82714. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8ZCV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFFALFIQR PVATTLLTLA ITLSGIIGFS LLPVSPLPQV DYPVIMVSAS
60 70 80 90 100
MPGADPETMA SSVATPLERA LGRIAGVNEM TSTSSLGSTR IILQFDLNRD
110 120 130 140 150
INGAARDVQA ALNAAQSLLP SGMPSRPTYR KMNPSDAPIM IMTLTSDTFS
160 170 180 190 200
QGQLYDYAST KLAQKIAQTE GVSDVTVGGS SLPAVRVELN PSALFNQGVS
210 220 230 240 250
LDAVRQAISA ANVRRPQGSV DAAETHWQVQ ANDEIKTAEG YRPLIVHYNN
260 270 280 290 300
GSPVRLQDVA NVIDSVQDVR NAGMSAGQPA VLLVISREPG ANIIATVDRI
310 320 330 340 350
RAELPALRAS IPASIQLNIA QDRSPTIRAS LDEVERSLVI AVALVILVVF
360 370 380 390 400
IFLRSGRATL IPAVAVPVSL IGTFAAMYLC GFSLNNLSLM ALTIATGFVV
410 420 430 440 450
DDAIVVLENI SRHLEAGVKP KVAALRGVRE VGFTVLSMSI SLVAVFIPLL
460 470 480 490 500
LMAGLPGRLF REFAVTLSVA IGISLVISLT LTPMMCAWLL RSHPKGQQQR
510 520 530 540 550
IRGFGKVLLA IQQGYGRSLN WALSHTRWVM VVLLSTIALN VWLYISIPKT
560 570 580 590 600
FFPEQDTGRM MGFIQADQSI SFQSMQQKLK DFMQIVGADP AVDSVTGFTG
610 620 630 640 650
GSRTNSGSMF ISLKPLSERQ ETAQQVITRL RGKLAKEPGA NLFLSSVQDI
660 670 680 690 700
RVGGRHSNAA YQFTLLADDL AALREWEPKV RAALAKLPQL ADVNSDQQDK
710 720 730 740 750
GAEMALTYDR ETMARLGIDV SEANALLNNA FGQRQISTIY QPLNQYKVVM
760 770 780 790 800
EVAPEYTQDV SSLDKMFVIN SNGQSIPLSY FAKWQPANAP LAVNHQGLSA
810 820 830 840 850
ASTISFNLPD GGSLSEATAA VERAMTELGV PSTVRGAFAG TAQVFQETLK
860 870 880 890 900
SQLWLIMAAI ATVYIVLGIL YESYVHPLTI LSTLPSAGVG ALLALELFDA
910 920 930 940 950
PFSLIALIGI MLLIGIVKKN AIMMVDFALD AQRNGNISAR EAIFQASLLR
960 970 980 990 1000
FRPIIMTTLA ALFGALPLVL SSGDGAELRQ PLGITIVGGL VVSQLLTLYT
1010 1020
TPVIYLYFDR LRNRFSKQPL MKLE
Length:1,024
Mass (Da):110,386
Last modified:March 1, 2002 - v1
Checksum:iCFA7627F2222F5FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL21461.1.
AE009952 Genomic DNA. Translation: AAM84956.1.
AE017042 Genomic DNA. Translation: AAS62905.1.
PIRiAB0347.
RefSeqiWP_002209794.1. NZ_LIXY01000015.1.
YP_002347787.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM84956; AAM84956; y1384.
AAS62905; AAS62905; YP_2716.
GeneIDi1175674.
KEGGiype:YPO2849.
ypk:y1384.
ypl:CH46_2254.
ypm:YP_2716.
ypv:BZ15_681.
ypw:CH59_3223.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL21461.1.
AE009952 Genomic DNA. Translation: AAM84956.1.
AE017042 Genomic DNA. Translation: AAS62905.1.
PIRiAB0347.
RefSeqiWP_002209794.1. NZ_LIXY01000015.1.
YP_002347787.1. NC_003143.1.

3D structure databases

ProteinModelPortaliQ8ZCV9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8ZCV9. 4 interactions.
STRINGi187410.y1384.

Protocols and materials databases

DNASUi1146331.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM84956; AAM84956; y1384.
AAS62905; AAS62905; YP_2716.
GeneIDi1175674.
KEGGiype:YPO2849.
ypk:y1384.
ypl:CH46_2254.
ypm:YP_2716.
ypv:BZ15_681.
ypw:CH59_3223.

Phylogenomic databases

eggNOGiENOG4105BZS. Bacteria.
COG0841. LUCA.
HOGENOMiHOG000158127.
KOiK07789.
OMAiMFVINSD.
OrthoDBiEOG6SFP62.

Enzyme and pathway databases

BioCyciYPES214092:GKDD-2812-MONOMER.

Family and domain databases

Gene3Di3.30.2090.10. 2 hits.
HAMAPiMF_01424. MdtC.
InterProiIPR027463. AcrB_DN_DC_subdom.
IPR001036. Acrflvin-R.
IPR023931. Multidrug-R_MdtC.
[Graphical view]
PfamiPF00873. ACR_tran. 1 hit.
[Graphical view]
PRINTSiPR00702. ACRIFLAVINRP.
SUPFAMiSSF82714. SSF82714. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiMDTC_YERPE
AccessioniPrimary (citable) accession number: Q8ZCV9
Secondary accession number(s): Q0WD51, Q74SA6, Q7CJL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.