Copper-exporting P-type ATPase A

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Q8ZCA7 (COPA_YERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 94. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Copper-exporting P-type ATPase A
EC=3.6.3.n1

Gene names

Name:	copA
Ordered Locus Names:	YPO3086, y1093, YP_0838

Organism

Yersinia pestis

Taxonomic identifier

632 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	961 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in copper export By similarity.
Catalytic activity	ATP + H₂O + Cu⁺(In) = ADP + phosphate + Cu⁺(Out).
Subcellular location	Cell membrane; Multi-pass membrane protein Probable.
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification] Contains 3 HMA domains.

Ontologies

Keywords
Biological process	Copper transport Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Repeat Transmembrane Transmembrane helix
Ligand	ATP-binding Copper Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW copper-exporting ATPase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 961

961

Copper-exporting P-type ATPase A

PRO_0000046325

Regions

Transmembrane

316 – 336

Helical; Potential

Transmembrane

345 – 365

Helical; Potential

Transmembrane

381 – 401

Helical; Potential

Transmembrane

565 – 585

Helical; Potential

Transmembrane

592 – 612

Helical; Potential

Transmembrane

860 – 880

Helical; Potential

Transmembrane

906 – 926

Helical; Potential

Transmembrane

928 – 948

Helical; Potential

Domain

4 – 65

HMA 1

Domain

70 – 131

HMA 2

Domain

227 – 290

HMA 3

Sites

Active site

650

4-aspartylphosphate intermediate Probable

Metal binding

Copper Potential

Metal binding

Copper Potential

Metal binding

Copper Potential

Metal binding

Copper Potential

Metal binding

237

Copper Potential

Metal binding

240

Copper Potential

Metal binding

847

Magnesium By similarity

Metal binding

851

Magnesium By similarity

Experimental info

Sequence conflict

376

R → S in AAM84670. Ref.2

Sequence conflict

376

R → S in AAS61097. Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

Q8ZCA7 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 8FE8B194BF356A33
Show »

FASTA

961

101,409

        10         20         30         40         50         60 
MLQTTLLALQ GLSCMNCAQR VKAALESRED VHHAEVNVHY AKVTGEADTH ALIETIKQTG 

        70         80         90        100        110        120 
YQATEAQTPD VELHLSGLSC GHCTETVRKA LEAVSGVISA DVTLESANVY GKADIQTLIA 

       130        140        150        160        170        180 
AVEQAGYHAT QQGIDSPKTE PLTHSAQSQP ESLAAAPNTV PATNVALATS TVSDTNTVLP 

       190        200        210        220        230        240 
TNTALPTNTT STTSTADTAS ATSTAPVINP LPVTESVAQP AASEGESVQL LLTGMSCASC 

       250        260        270        280        290        300 
VSKVQNALQR VDGVQVARVN LAERSALVTG TQNNEALIAA VKNAGYGAEI IEDEGERRER 

       310        320        330        340        350        360 
QQQMSQASMK RFQWQAALGL LLGIPLMAWG LFGGSMTLTP ETQTPWLIIG IITLLVMIFA 

       370        380        390        400        410        420 
GGHFYRNAWV SLKNGRATMD TLVALGTGAA WIYSITVNIW PDVFPMEARH LYYEASAMII 

       430        440        450        460        470        480 
GLINLGHAME QRARQRSSNA LERLLDLAPP TAKLVTDDGE KVIPLADVQL GMILRLTTGD 

       490        500        510        520        530        540 
RVPVDGEIVQ GEVWMDEAML TGEPIPQQKS VGDIVHAGTQ VQDGTVQFRA SAIGSQTTLA 

       550        560        570        580        590        600 
RIIKLVRQAQ SSKPEIGKLA DRISAVFVPT VVVIAIVAGL IWYFFGPQPQ LVYTLVVATT 

       610        620        630        640        650        660 
VLIIACPCAL GLATPMSIIS GVGRAAEFGV LVRDADALQQ ASNLDTLVFD KTGTLTEGHP 

       670        680        690        700        710        720 
QVVAIHTFNG VSEQQALGWA AALETGSNHP LARAILQRAE GLTLATASQF RTLRGLGVSG 

       730        740        750        760        770        780 
EVDGIPLLLG NNRLLEEQQI DTRELQSLIQ QQAESGATPV ILTANGKPAA LLSIRDPLRE 

       790        800        810        820        830        840 
DSIGALQRLH QLGYSLVMLT GDNPITANAI AKEAGIDRVI AGVLPDGKAD AIKQLQAAGH 

       850        860        870        880        890        900 
KVAMIGDGIN DAPALAQADV GIAMGGGSDI AIETAAITLM RHSLYGVVDA VELSKATLRN 

       910        920        930        940        950        960 
MKQNLLGAFF YNALGIPIAA GILYPFTGTL LSPVVAGAAM ALSSITVVSN ANRLLRFKPK 


Q

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References

[1]	"Genome sequence of Yersinia pestis, the causative agent of plague." Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. Barrell B.G. Nature 413:523-527(2001) [PubMed: 11586360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CO-92 / Biovar Orientalis.
[2]	"Genome sequence of Yersinia pestis KIM." Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. , Matson J.S., Blattner F.R., Perry R.D. J. Bacteriol. 184:4601-4611(2002) [PubMed: 12142430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KIM5 / Biovar Mediaevalis.
[3]	"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans." Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. Yang R. DNA Res. 11:179-197(2004) [PubMed: 15368893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL590842 Genomic DNA. Translation: CAL21688.1. AE009952 Genomic DNA. Translation: AAM84670.1. AE017042 Genomic DNA. Translation: AAS61097.1.
PIR	AE0375.
RefSeq	NP_668419.1. NC_004088.1. NP_992220.1. NC_005810.1. YP_002348006.1. NC_003143.1.
3D structure databases
ProteinModelPortal	Q8ZCA7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1146039. 1175907. 2764600.
GenomeReviews	Gene locus y1093 in contig AE009952_GR. Gene locus YP_0838 in contig AE017042_GR. Gene locus YPO3086 in contig AL590842_GR.
KEGG	ype:YPO3086. ypk:y1093. ypm:YP_0838.
Phylogenomic databases
HOGENOM	HBG507745.
OMA	INGMSCA.
ProtClustDB	PRK10671.
Enzyme and pathway databases
BioCyc	YPES187410:Y1093-MONOMER. YPES214092:YPO3086-MONOMER.
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR006403. ATPase_P-typ_cat/Cu-transptr. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR006416. ATPase_P-typ_heavy-metal. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR005834. Dehalogen-like_hydro. IPR023214. HAD-like_dom. IPR017969. Heavy-metal-associated_CS. IPR006121. HeavyMe-assoc_HMA. IPR000150. Hypothet_cof. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 1 hit. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit. G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
KO	K01533.
Pfam	PF00122. E1-E2_ATPase. 1 hit. PF00403. HMA. 3 hits. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00943. CUATPASE.
SUPFAM	SSF56784. HAD-like_dom. 1 hit. SSF55008. HeavyMe_transpt. 3 hits.
TIGRFAMs	TIGR01511. ATPase-IB1_Cu. 1 hit. TIGR01525. ATPase-IB_hvy. 1 hit. TIGR01494. ATPase_P-type. 1 hit.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. PS01047. HMA_1. 3 hits. PS50846. HMA_2. 3 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COPA_YERPE

Accession

Primary (citable) accession number: Q8ZCA7
Secondary accession number(s): Q0WCI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2002
Last sequence update:	March 1, 2002
Last modified:	November 16, 2011
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents