Q8ZCA7 (COPA_YERPE) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 94.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Copper-exporting P-type ATPase A EC=3.6.3.n1 | ||||
| Gene names |
| ||||
| Organism | Yersinia pestis | ||||
| Taxonomic identifier | 632 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia |
Protein attributes
| Sequence length | 961 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Involved in copper export By similarity. |
| Catalytic activity | ATP + H2O + Cu+(In) = ADP + phosphate + Cu+(Out). |
| Subcellular location | Cell membrane; Multi-pass membrane protein Probable. |
| Sequence similarities | Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification] Contains 3 HMA domains. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Copper transport Ion transport Transport |
| Cellular component | Cell membrane Membrane |
| Domain | Repeat Transmembrane Transmembrane helix |
| Ligand | ATP-binding Copper Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Hydrolase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | ATP biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW copper-exporting ATPase activityInferred from electronic annotation. Source: InterPro metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 961 | 961 | Copper-exporting P-type ATPase A | PRO_0000046325 | |||||
Regions | |||||||||
| Transmembrane | 316 – 336 | 21 | Helical; Potential | ||||||
| Transmembrane | 345 – 365 | 21 | Helical; Potential | ||||||
| Transmembrane | 381 – 401 | 21 | Helical; Potential | ||||||
| Transmembrane | 565 – 585 | 21 | Helical; Potential | ||||||
| Transmembrane | 592 – 612 | 21 | Helical; Potential | ||||||
| Transmembrane | 860 – 880 | 21 | Helical; Potential | ||||||
| Transmembrane | 906 – 926 | 21 | Helical; Potential | ||||||
| Transmembrane | 928 – 948 | 21 | Helical; Potential | ||||||
| Domain | 4 – 65 | 62 | HMA 1 | ||||||
| Domain | 70 – 131 | 62 | HMA 2 | ||||||
| Domain | 227 – 290 | 64 | HMA 3 | ||||||
Sites | |||||||||
| Active site | 650 | 1 | 4-aspartylphosphate intermediate Probable | ||||||
| Metal binding | 14 | 1 | Copper Potential | ||||||
| Metal binding | 17 | 1 | Copper Potential | ||||||
| Metal binding | 80 | 1 | Copper Potential | ||||||
| Metal binding | 83 | 1 | Copper Potential | ||||||
| Metal binding | 237 | 1 | Copper Potential | ||||||
| Metal binding | 240 | 1 | Copper Potential | ||||||
| Metal binding | 847 | 1 | Magnesium By similarity | ||||||
| Metal binding | 851 | 1 | Magnesium By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 376 | 1 | R → S in AAM84670. Ref.2 | ||||||
| Sequence conflict | 376 | 1 | R → S in AAS61097. Ref.3 | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL590842 Genomic DNA. Translation: CAL21688.1. AE009952 Genomic DNA. Translation: AAM84670.1. AE017042 Genomic DNA. Translation: AAS61097.1. |
| PIR | AE0375. |
| RefSeq | NP_668419.1. NC_004088.1. NP_992220.1. NC_005810.1. YP_002348006.1. NC_003143.1. |
3D structure databases | |
| ProteinModelPortal | Q8ZCA7. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1146039. 1175907. 2764600. |
| GenomeReviews | Gene locus y1093 in contig AE009952_GR. Gene locus YP_0838 in contig AE017042_GR. Gene locus YPO3086 in contig AL590842_GR. |
| KEGG | ype:YPO3086. ypk:y1093. ypm:YP_0838. |
Phylogenomic databases | |
| HOGENOM | HBG507745. |
| OMA | INGMSCA. |
| ProtClustDB | PRK10671. |
Enzyme and pathway databases | |
| BioCyc | YPES187410:Y1093-MONOMER. YPES214092:YPO3086-MONOMER. |
Family and domain databases | |
| InterPro | IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR006403. ATPase_P-typ_cat/Cu-transptr. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR006416. ATPase_P-typ_heavy-metal. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR005834. Dehalogen-like_hydro. IPR023214. HAD-like_dom. IPR017969. Heavy-metal-associated_CS. IPR006121. HeavyMe-assoc_HMA. IPR000150. Hypothet_cof. [Graphical view] |
| Gene3D | G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 1 hit. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit. G3DSA:3.40.50.1000. HAD-like_dom. 2 hits. |
| KO | K01533. |
| Pfam | PF00122. E1-E2_ATPase. 1 hit. PF00403. HMA. 3 hits. PF00702. Hydrolase. 1 hit. [Graphical view] |
| PRINTS | PR00119. CATATPASE. PR00943. CUATPASE. |
| SUPFAM | SSF56784. HAD-like_dom. 1 hit. SSF55008. HeavyMe_transpt. 3 hits. |
| TIGRFAMs | TIGR01511. ATPase-IB1_Cu. 1 hit. TIGR01525. ATPase-IB_hvy. 1 hit. TIGR01494. ATPase_P-type. 1 hit. |
| PROSITE | PS00154. ATPASE_E1_E2. 1 hit. PS01047. HMA_1. 3 hits. PS50846. HMA_2. 3 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | COPA_YERPE | ||||||||
| Accession | Primary (citable) accession number: Q8ZCA7 Secondary accession number(s): Q0WCI2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with