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Protein

2-dehydropantoate 2-reductase

Gene

panE

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei31 – 311NADP; via amide nitrogenBy similarity
Binding sitei98 – 981NADP; via amide nitrogenBy similarity
Binding sitei98 – 981SubstrateBy similarity
Binding sitei122 – 1221NADP; via amide nitrogen and carbonyl oxygenBy similarity
Active sitei176 – 1761Proton donorBy similarity
Binding sitei180 – 1801SubstrateBy similarity
Binding sitei184 – 1841SubstrateBy similarity
Binding sitei194 – 1941SubstrateBy similarity
Binding sitei241 – 2411SubstrateBy similarity
Binding sitei244 – 2441SubstrateBy similarity
Binding sitei256 – 2561NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 126NADPBy similarity

GO - Molecular functioni

  1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciYPES214092:GKDD-3124-MONOMER.
UniPathwayiUPA00028; UER00004.

Names & Taxonomyi

Protein namesi
Recommended name:
2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Name:panE
Synonyms:apbA
Ordered Locus Names:YPO3171, y1014, YP_0760
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3033032-dehydropantoate 2-reductasePRO_0000157307Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiQ8ZC51. 2 interactions.
STRINGi214092.YPO3171.

Structurei

3D structure databases

ProteinModelPortaliQ8ZC51.
SMRiQ8ZC51. Positions 1-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ketopantoate reductase family.Curated

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000050223.
KOiK00077.
OMAiMSSTWHI.
OrthoDBiEOG68SVW3.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZC51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKITVLGCGA LGQLWLSMLH QQDHDVQGWL RVPQPFCSVN VIMLNGESFN
60 70 80 90 100
RNLTTNDPKH LLQSELLLVC LKAWQVSSAV TALLPKLNPE CKILLLHNGM
110 120 130 140 150
GTQEELPLNE HVFLHGVTTH AARRDGNTII HVASGMTHIG PTSSVIIDDN
160 170 180 190 200
HLADTLHQAL PDVAWHNDIS AACWQKLAVN CVINPLTGLY NCRNGDVQRY
210 220 230 240 250
PELIERLCAE VASVMEMEGY HTSTESLLSY VNNVIRSTAD NTSSLLQDLR
260 270 280 290 300
SQRHTEIDYI TGYLLRRARS HGMALPENAR LYELIKRKES DYERIGAGLP

GSW
Length:303
Mass (Da):33,844
Last modified:February 21, 2002 - v1
Checksum:i3B1D8198D053B9BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL21766.1.
AE009952 Genomic DNA. Translation: AAM84595.1.
AE017042 Genomic DNA. Translation: AAS61025.1.
PIRiAC0385.
RefSeqiNP_668344.1. NC_004088.1.
NP_992148.1. NC_005810.1.
YP_002348076.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM84595; AAM84595; y1014.
AAS61025; AAS61025; YP_0760.
GeneIDi1145961.
1175986.
2764026.
KEGGiype:YPO3171.
ypk:y1014.
ypm:YP_0760.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL21766.1.
AE009952 Genomic DNA. Translation: AAM84595.1.
AE017042 Genomic DNA. Translation: AAS61025.1.
PIRiAC0385.
RefSeqiNP_668344.1. NC_004088.1.
NP_992148.1. NC_005810.1.
YP_002348076.1. NC_003143.1.

3D structure databases

ProteinModelPortaliQ8ZC51.
SMRiQ8ZC51. Positions 1-293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8ZC51. 2 interactions.
STRINGi214092.YPO3171.

Protocols and materials databases

DNASUi1145961.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM84595; AAM84595; y1014.
AAS61025; AAS61025; YP_0760.
GeneIDi1145961.
1175986.
2764026.
KEGGiype:YPO3171.
ypk:y1014.
ypm:YP_0760.

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000050223.
KOiK00077.
OMAiMSSTWHI.
OrthoDBiEOG68SVW3.

Enzyme and pathway databases

UniPathwayiUPA00028; UER00004.
BioCyciYPES214092:GKDD-3124-MONOMER.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiPANE_YERPE
AccessioniPrimary (citable) accession number: Q8ZC51
Secondary accession number(s): Q0WCB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 21, 2002
Last modified: January 7, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.