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Q8ZC51

- PANE_YERPE

UniProt

Q8ZC51 - PANE_YERPE

Protein

2-dehydropantoate 2-reductase

Gene

panE

Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (21 Feb 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

    Catalytic activityi

    (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei31 – 311NADP; via amide nitrogenBy similarity
    Binding sitei98 – 981NADP; via amide nitrogenBy similarity
    Binding sitei98 – 981SubstrateBy similarity
    Binding sitei122 – 1221NADP; via amide nitrogen and carbonyl oxygenBy similarity
    Active sitei176 – 1761Proton donorBy similarity
    Binding sitei180 – 1801SubstrateBy similarity
    Binding sitei184 – 1841SubstrateBy similarity
    Binding sitei194 – 1941SubstrateBy similarity
    Binding sitei241 – 2411SubstrateBy similarity
    Binding sitei244 – 2441SubstrateBy similarity
    Binding sitei256 – 2561NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 126NADPBy similarity

    GO - Molecular functioni

    1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciYPES214092:GKDD-3124-MONOMER.
    UniPathwayiUPA00028; UER00004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-dehydropantoate 2-reductase (EC:1.1.1.169)
    Alternative name(s):
    Ketopantoate reductase
    Short name:
    KPA reductase
    Short name:
    KPR
    Gene namesi
    Name:panE
    Synonyms:apbA
    Ordered Locus Names:YPO3171, y1014, YP_0760
    OrganismiYersinia pestis
    Taxonomic identifieri632 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3033032-dehydropantoate 2-reductasePRO_0000157307Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    IntActiQ8ZC51. 2 interactions.
    STRINGi214092.YPO3171.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8ZC51.
    SMRiQ8ZC51. Positions 1-293.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ketopantoate reductase family.Curated

    Phylogenomic databases

    eggNOGiCOG1893.
    HOGENOMiHOG000050223.
    KOiK00077.
    OMAiQEVAFLI.
    OrthoDBiEOG68SVW3.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8ZC51-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKITVLGCGA LGQLWLSMLH QQDHDVQGWL RVPQPFCSVN VIMLNGESFN    50
    RNLTTNDPKH LLQSELLLVC LKAWQVSSAV TALLPKLNPE CKILLLHNGM 100
    GTQEELPLNE HVFLHGVTTH AARRDGNTII HVASGMTHIG PTSSVIIDDN 150
    HLADTLHQAL PDVAWHNDIS AACWQKLAVN CVINPLTGLY NCRNGDVQRY 200
    PELIERLCAE VASVMEMEGY HTSTESLLSY VNNVIRSTAD NTSSLLQDLR 250
    SQRHTEIDYI TGYLLRRARS HGMALPENAR LYELIKRKES DYERIGAGLP 300
    GSW 303
    Length:303
    Mass (Da):33,844
    Last modified:February 21, 2002 - v1
    Checksum:i3B1D8198D053B9BE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL21766.1.
    AE009952 Genomic DNA. Translation: AAM84595.1.
    AE017042 Genomic DNA. Translation: AAS61025.1.
    PIRiAC0385.
    RefSeqiNP_668344.1. NC_004088.1.
    NP_992148.1. NC_005810.1.
    YP_002348076.1. NC_003143.1.

    Genome annotation databases

    EnsemblBacteriaiAAM84595; AAM84595; y1014.
    AAS61025; AAS61025; YP_0760.
    GeneIDi1145961.
    1175986.
    2764026.
    KEGGiype:YPO3171.
    ypk:y1014.
    ypm:YP_0760.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL21766.1 .
    AE009952 Genomic DNA. Translation: AAM84595.1 .
    AE017042 Genomic DNA. Translation: AAS61025.1 .
    PIRi AC0385.
    RefSeqi NP_668344.1. NC_004088.1.
    NP_992148.1. NC_005810.1.
    YP_002348076.1. NC_003143.1.

    3D structure databases

    ProteinModelPortali Q8ZC51.
    SMRi Q8ZC51. Positions 1-293.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8ZC51. 2 interactions.
    STRINGi 214092.YPO3171.

    Protocols and materials databases

    DNASUi 1145961.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM84595 ; AAM84595 ; y1014 .
    AAS61025 ; AAS61025 ; YP_0760 .
    GeneIDi 1145961.
    1175986.
    2764026.
    KEGGi ype:YPO3171.
    ypk:y1014.
    ypm:YP_0760.

    Phylogenomic databases

    eggNOGi COG1893.
    HOGENOMi HOG000050223.
    KOi K00077.
    OMAi QEVAFLI.
    OrthoDBi EOG68SVW3.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00004 .
    BioCyci YPES214092:GKDD-3124-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CO-92 / Biovar Orientalis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIM10+ / Biovar Mediaevalis.
    3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
      Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
      , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
      DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 91001 / Biovar Mediaevalis.

    Entry informationi

    Entry nameiPANE_YERPE
    AccessioniPrimary (citable) accession number: Q8ZC51
    Secondary accession number(s): Q0WCB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2002
    Last sequence update: February 21, 2002
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3