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Protein

Acyl carrier protein phosphodiesterase

Gene

acpH

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.UniRule annotation

Catalytic activityi

Holo-[acyl-carrier-protein] + H2O = 4'-phosphopantetheine + apo-[acyl-carrier-protein].UniRule annotation

GO - Molecular functioni

  1. [acyl-carrier-protein] phosphodiesterase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciYPES214092:GKDD-3147-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl carrier protein phosphodiesteraseUniRule annotation (EC:3.1.4.14UniRule annotation)
Short name:
ACP phosphodiesteraseUniRule annotation
Gene namesi
Name:acpHUniRule annotation
Ordered Locus Names:YPO3193, y0989, YP_0738
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Acyl carrier protein phosphodiesterasePRO_0000226278Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi214092.YPO3193.

Family & Domainsi

Sequence similaritiesi

Belongs to the AcpH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3124.
HOGENOMiHOG000275880.
KOiK08682.
OMAiHFLAKNW.
OrthoDBiEOG6K6V7H.

Family and domain databases

HAMAPiMF_01950. AcpH.
InterProiIPR007431. ACP_phosphodiesterase.
IPR023491. ACP_phosphodiesterase_gpbac.
[Graphical view]
PfamiPF04336. DUF479. 1 hit.
[Graphical view]
PIRSFiPIRSF011489. DUF479. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZC31-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNFLAHLHLA ALADSSLLGN LLADFVRGNP QGEYPPEIVA GIMMHRRVDV
60 70 80 90 100
MTDTLPLVKE ARTYFSADYR RVSPITLDVL WDHFLARHWD QLVPNCTLPD
110 120 130 140 150
FLQHAQSQIL PHLPHTPARF QSLNAYLWSE RWLERYAELP FIADVLQGMA
160 170 180 190
NRRPKLAALA GSFYAIEQHY QPLEDLFLTF YPTMMRQAQH KQI
Length:193
Mass (Da):22,351
Last modified:March 1, 2002 - v1
Checksum:i6921FA82A025990A
GO

Sequence cautioni

The sequence AAM84570.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAS61003.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL21788.1.
AE009952 Genomic DNA. Translation: AAM84570.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS61003.1. Different initiation.
PIRiAI0387.
RefSeqiNP_668319.1. NC_004088.1.
NP_992126.1. NC_005810.1.
YP_002348098.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM84570; AAM84570; y0989.
AAS61003; AAS61003; YP_0738.
GeneIDi1145936.
1176008.
2765747.
KEGGiype:YPO3193.
ypk:y0989.
ypm:YP_0738.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL21788.1.
AE009952 Genomic DNA. Translation: AAM84570.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS61003.1. Different initiation.
PIRiAI0387.
RefSeqiNP_668319.1. NC_004088.1.
NP_992126.1. NC_005810.1.
YP_002348098.1. NC_003143.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi214092.YPO3193.

Protocols and materials databases

DNASUi1145936.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM84570; AAM84570; y0989.
AAS61003; AAS61003; YP_0738.
GeneIDi1145936.
1176008.
2765747.
KEGGiype:YPO3193.
ypk:y0989.
ypm:YP_0738.

Phylogenomic databases

eggNOGiCOG3124.
HOGENOMiHOG000275880.
KOiK08682.
OMAiHFLAKNW.
OrthoDBiEOG6K6V7H.

Enzyme and pathway databases

BioCyciYPES214092:GKDD-3147-MONOMER.

Family and domain databases

HAMAPiMF_01950. AcpH.
InterProiIPR007431. ACP_phosphodiesterase.
IPR023491. ACP_phosphodiesterase_gpbac.
[Graphical view]
PfamiPF04336. DUF479. 1 hit.
[Graphical view]
PIRSFiPIRSF011489. DUF479. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiACPH_YERPE
AccessioniPrimary (citable) accession number: Q8ZC31
Secondary accession number(s): Q0WC90, Q74WU4, Q8D165
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 1, 2002
Last modified: February 4, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.